Medications for Scleroderma, Arthritis,
Autoimmune and Rheumatic Diseases |
| This page was written by Janey Willis and has not yet been medically edited. See Disclaimer. |
| |
| NSAIDs, Anti-Inflammatories, Pain Medications |
| |
| Overview of NSAIDs |
| NSAIDs. A concise list of Nonsteroidal anti-inflammatory drugs. Arthritis Foundation. |
| Information for Patients About NSAIDs. Traditional NSAIDs include aspirin, ibuprofen (e.g., Advil, Motrin), naproxen (e.g., Aleve) and many other generic and brand name drugs. A newer addition to the NSAID group is celecoxib (Celebrex) which is a COX 2 Selective NSAID. American College of Rheumatology. |
| Nonsteroidal anti-inflammatory drugs (NSAIDs). Non Steroidal Anti-Inflammatory Drugs (NSAIDs) are medications which, as well as having pain-relieving (analgesic) effects, have the effect of reducing inflammation when used over a period of time. MedInfo.co.uk. |
| Taking more than one painkiller risky: study. People who use two or more non-steroidal anti-inflammatory drugs (NSAIDs) to help control pain have a worse health-related quality of life than their peers who use only one, results of a study suggest. Reuters. 02/11/08. |
| Patients with Rheumatoid Arthritis Undergoing Surgery: How Should We Deal with Antirheumatic Treatment? Continuation of methotrexate (MTX) appears to be safe in the perioperative period. To avoid the antiplatelet effect during surgery, NSAIDs other than aspirin should be withheld for a duration of 4 to 5 times the drug half-life. (Science Direct) Seminars in Arthritis and Rheumatism Vol 36, Issue 5, April 2007, Pages 278-286. (Also see: RA ) |
| Scleroderma Treatments and Clinical Trials ISN. |
| Possible Side Effects of NSAIDs |
| NSAIDs. Dosage,Side Effects, Drug Interactions, Warnings. About.com. |
| Acetaminophen and the Risk of Asthma. A growing body of multidisciplinary evidence backed by biochemical explanations suggests that frequent acetaminophen use may also have a negative impact on lung function. Chest. 2005;127:604-612. (Also see: Asthma ) |
| Use of NSAIDs and infection with Helicobacter pylori-what does the rheumatologist need to know? Ulcer risk reduction after H. pylori eradication therapy is clearly more marked in patients beginning NSAID therapy than in patients who were already receiving and tolerating NSAID therapy. U. Kiltz. Rheumatology Advance Access. May 13, 2008 (Also see: GI Involvement ). |
| American Heart Association statement recommends doctors change approach. Many doctors should change the way they prescribe pain relievers for chronic pain in patients with or at risk for heart disease based on accumulated evidence that nonsteroidal anti-inflammatory drugs (NSAIDs), with the exception of aspirin, increase risk for heart attack and stroke. EurekAlert! 02/26/07. (Also see: Cardiac Involvement ) |
| Study Shows Pain Drugs in Your Medicine Cabinet Carry Risk of High Blood Pressure. The most widely used medicines in the world (over-the-counter pain drugs) raise a person's risk of high blood pressure. It's true for men as well as for women. MedicineNet.com. 02/26/07. |
| Popular Painkillers Linked to Hospital Admissions For Heart Failure. A British study has shown that nonsteroidal anti-inflammatory (NSAID) drugs raise older patients' risk of a first hospital admission for heart failure by 30%. the study looked at people aged 60-84. Not only do NSAIDs raise th erisk for patients with a history of cardiovascular disease, but also people without any history of heart disease. Medical News Today. 05/22/06. |
| Study examines NSAID use and breast cancer risk. Ibuprofen use is associated with an increased risk of breast cancer, and long-term daily use of aspirin is associated with an increased risk of estrogen receptor/progesterone receptor (ER/PR)-negative breast cancer, according to a new study in the June 1 issue of the Journal of the National Cancer Institute. EurekAlert! 05/30/05. (Also see: Scleroderma and Cancer) |
| FDA Warning about NSAIDs |
| COX-2 Selective (includes Bextra, Celebrex, and Vioxx) and Non-Selective Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). Manufacturers of non-prescription (over-the-counter) NSAIDs are being asked to revise their labeling to provide more specific information about the potential cardiovascular and gastrointestinal risks of their individual products and remind patients of the limited dose and duration of treatment of these products in accordance with the package instructions. FDA. July, 2005. |
| FDA Issues Public Health Advisory on the Fentanyl (Duragesic) Patch in response to reports of deaths in patients using this potent narcotic medication for pain management. Medical News Today 07/18/05. |
| Cox-2 Inhibitors |
| COX-2 inhibitors are a form of non-steroidal anti-inflammatory drug (NSAID) that directly targets COX-2, an enzyme responsible for inflammation and pain. Celebrex and Vioxx are Cox-2 inhibitors. ISN. |
| Cox-2 Inhibitors. The COX-2 inhibitors represent a new class of drugs that do not affect COX-1, but selectively block only COX-2. This selective action provides the benefits of reducing inflammation without irritating the stomach. MedicineNet.com. |
| Cox-2 Use Is Down, but Ulcers Are Up. Patients turn to traditional NSAID painkillers but skip drugs that protect their stomachs. WebMD. 11/10/07. |
| Celebrex research indicates heart risk. Side effects similar to those of Vioxx—FDA has 'concerns'. In a soon-to-be-published letter released early by the New England Journal of Medicine, three Vanderbilt University researchers recommended that doctors stop prescribing the drug (Celebrex) because of its cardiovascular risks. San Francisco Chronicle 12/18/04. |
| Arthritis Drug Vioxx Recalled. Merck & Co. is pulling its blockbuster arthritis drug Vioxx from the market worldwide because new data from a clinical trial found an increased risk of heart attack and stroke. Merck said Thursday that data from the trial showed the increased risk of heart attack and other cardiovascular complications began 18 months after patients started taking Vioxx. CBS News 09/30/04. (Also see: Medications) |
