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Associated Conditions: MAIN MENU
Medical (Main Page) Skin Diseases (MAIN MENU)
ASSOCIATED CONDITIONS: MAIN MENU
It is common for people with scleroderma to also have other health problems, and here are a few items often associated with it. Just because something is listed here does not mean an individual patient will ever experience it. See Disclaimer.
Anemia of Chronic Disease
Antiphospholipid Syndrome
Arthritis
Asthma
Autoimmunity
Behcet's
Cancer
Celiac Disease
Chronic Fatigue Syndrome
Depression
Dermatology (General)
Dermatomyositis
Diabetes
Ear Diseases, Autoimmune
Ehlers-Danlos syndromes (EDS)
Endometriosis
Eye Diseases, Autoimmune
Fatigue
Fibromyalgia
Glaucoma/Retinal Involvement
Guillain-Barre
Idiopathic Thromocytopenic Purpura
Interstitial Cystitis

Leukemia
Marfan syndrome (MFS)

MCTD
Multiple Sclerosis
Myasthenia Gravis
Neuromuscular Diseases
Pancytopenia
Polyarteritis Nodosa
Polymyositis
Psoriasis, PsA
Rheumatoid Arthritis
Sarcoidosis
Scleroderma
Similar Skin Diseases
Systemic Lupus (SLE)
Thrombotic Purpura (TTP)
Thyroid Disease
TB & Scleroderma
Tuberculous Fasciitis
UCTD
Vasculitis
Vulvodynia
Wegener's Granulomatosis
Anemia of Chronic Disease
Anemia of Chronic Disease. Anemia refers to a deficiency in the blood. Anemia most commonly refers to insufficient iron resulting in a shortage of hemoglobin, but the term is also used to indicate vitamin deficiency or blood loss. Anemia can range from mild and temporary to severe and life-threatening. When the anemia is caused by a chronic illness, it is called "anemia of chronic disease." ISN.
Overview
What is Anemia?
Types of Anemia
Symptoms of Anemia
Diagnosis of Anemia
What is Anemia of Chronic Disease?
Causes of Anemia of Chronic Disease
Treatments for ACD
Personal Stories about ACD
Antiphospholipid Syndrome
Antiphospholipid Syndrome Symptoms include deep vein thrombosis, chronic leg ulcers, recurrent miscarriages, headache, heart attacks, renal vein and artery thrombosis, pulmonary embolism, and pulmonary hypertension. It is identified by the presence of anticardiolipin antibodies, in a blood test. The same antibodies have been associated with generalized morphea scleroderma. ISN.
What is APS?
APS and Heart Disease
Scleroderma and APS
Symptoms of APS
Complications of APS
Treatments for APS
Causes of APS and Research
Support Organizations for APS
Personal Stories about APS
Media Stories about APS
Arthritis
Scleroderma is classified as an arthritic disease, along with rheumatoid arthritis, lupus, dermatomyositis, and more than 100 other medical conditions..
Overview of Arthritis
Autoimmune Arthritis
Complications with Arthritis
Diagnosis of Arthrtis
Managing Arthritis
Symptoms of Arthritis
Treatments for Arthritis
Asthma
Asthma Risk Related To Decreased Fruit and Vitamin C consumption. A new study indicates that people suffering from symptomatic asthma eat less fruit and have decreased intake of vitamin C and manganese than their counterparts without the problem. News for the Day. 05/21/06. 1193.
The Relation Between Gastroesophageal Reflux and Respiratory Symptoms in a Population-Based Study. Reflux symptoms commonly coexist with asthma and other respiratory symptoms on a population-based level, seemingly irrespective of asthma medication. Chest. 2006;129:1051-1056. . (Also see: Heartburn)
A new view of Asthma's cause. Previously unrecognized immune cell may provide a better target for Asthma therapy. They examined specimens from the lungs of 25 adults: 14 with moderate-to-severe bronchial asthma, 6 healthy subjects and 5 patients with sarcoidosis, a respiratory inflammatory disease. eMaxHealth.com. 03/16/06.
Autoimmune Ear Disease
Autoimmune Ear Disease ISN.
What is Autoimmune Ear Disease?
Causes of Hearing Loss: Medications
Ménière's Disease
Tympanosclerosis
A Patient's Perspective
Research
Personal Stories
Media Stories
Related Links
Autoimmunity
What is Autoimmunity?
Causes of Autoimmunity
Diagnosis of Autoimmunity
Polyautoimmunity
Symptoms of Autoimmunity
Treating Autoimmunity
Related Books
Behcet's
Behcet's disease is a type of vasculitis characterized by mouth sores, genital sores, inflammation inside of the eye, skin problems, and arthritis (swelling of the joints).The disease usually affects more men than women. The disease appears to be more severe in young, male, and Middle Eastern or Far Eastern patients. Vasculitis Foundation.
What is Behcet's?
Symptoms of Behcet's
Causes of Behcet's
Diagnosis of Behcet's
Treatments for Behcet's
Cancer
Scleroderma and Cancer. Systemic sclerosis (scleroderma) may be associated with an increased incidence of cancer, including breast cancer, B-cell lymphoma, lung cancer and tongue cancer. ISN
Overview
Angiosarcoma
Autoantibodies
B-Cell Lymphoma
Breast Cancer
Malignant Atrophic Papulosis/Degos
MALT Lymphoma
Non-Hodgkin's Lymphoma
NSAIDs and Cancer
Liver Cancer
Lung Cancer
Melanoma
Myeloma (Bone Marrow Cancer)
T Cell Lymphoma
Tongue Cancer
Personal Stories
Celiac Disease and Gluten Sensitivity
Celiac Disease and Gluten Sensitivity. Celiac disease is a known cause of scleroderma and dozens of other autoimmune diseases, including Hashimoto's thyroiditis, psoriasis, and Sjogren's syndrome. ISN.
What is Gluten Sensitivity?
What is Celiac Disease?
Causes of Celiac Disease or Gluten Sensitivity
Celiac Disease and Autoimmunity
Diagnosis of Celiac Disease
Symptoms of Celiac Disease
Treatment of Celiac Disease
Media Articles
Personal Stories
Chronic Fatigue Syndrome (CFS)
Chronic Fatigue Syndrome Symptoms, diagnostic criteria, treatments and research for CFS and Fibromyalgia. ISN.
Relationship Between CFS/FMS
What is CFS?
What is Fibromyalgia?
Causes of CFS/FMS
CFS Causes
FMS Causes
Diagnosis of CFS/FMS
CFS Diagnosis
FMS Diagnosis
Treatments of CFS/FMS
CFS Treatments
FMS Treatments
Alternative and Nutritional
FMS General Management
FMS and Exercise
FMS Medications
Related Symptoms or Disorders
Autoimmune and Scleroderma
Gastrointestinal
Interstitial Cystitis (IC)
Lupus
Scleroderma
Temporomandibular Joint Disorder
Disability Info for CFS/FMS
Research about CFS/FMS
CFS Psychosocial Research
FMS Psychosocial Research
FMS Medical Research: Pain
Support for CFS/FMS
Personal Stories about CFS/FMS
Depression
Overview of Depression
Depression and Autoimmunity
Treating Depression
Alcohol and Depression
Personal Stories
Dermatology (General)
Dermatology a great site. DermWeb.
Skin and Connective Tissue Diseases Karolinska Institutet, Sweden.
Dermatomyositis and Polymyositis
Dermatomyositis and Polymyositis. Polymyositis is an inflammatory condition of the muscles; dermatomyositis is an inflammatory condition of the skin and muscles, which causes a distinctive rash. ISN.
What are Myopathies?
What is Dermatomyositis?
What is Polymyositis?
Symptoms of Dermatomyositis/Polymyositis
Scleroderma and Dermatomyositis/Polymyositis
Treatments for Dermatomyositis/Polymyositis

Research
Personal Stories
Diabetes
Diabetes. Topics include symptoms, causes, diagnosis, treatments, research, personal stories and media stories about diabetes. ISN.
Overview of Diabetes
Symptoms of Diabetes
Causes of Diabetes
Diagnosis of Diabetes
Scleroderma and Diabetes
Prevention of Diabetes
Diabetic Supplies
Treatment for Diabetes
Research on Diabetes
Support for Diabetes
Personal Stories of Diabetes
Media Stories about Diabetes
Ehlers-Danlos syndrome (EDS)
Ehlers-Danlos syndromes and Marfan syndrome. Ehlers-Danlos syndromes (EDS) and Marfan syndrome (MFS) are multisystemic disorders that primarily affect the soft connective tissues. (ScienceDirect) Best Practice & Research Clinical Rheumatology Vol 22, Issue 1, March 2008, Pp 165-189. (Also see: MFS)
Endometriosis
Pathogenesis of endometriosis: natural immunity dysfunction or autoimmune disease? Recently, endometriosis has also been considered to be an autoimmune disease, owing to the presence of autoantibodies, the association with other autoimmune diseases and recurrent immune-mediated abortion. These findings are in apparent contradiction with the reduced cell-mediated natural immunity observed during the disease. PubMed. Trends Mol Med 2003 May;9(5):223-228.
March is Endometriosis Awareness Month. Endometriosis is a painful reproductive and immunological disease in which uterine lining migrates outside the uterus, implants in other areas of the body and abnormally grows. eMediaWire 03/03/05.
Krisha S: Multiple Autoimmune Condition I have endometriosis, multiple sclerosis (MS), fibromyalgia, and Stiff Person Syndrome...
Kym: Diffuse, CREST Scleroderma, Lupus and Fibromyalgia It all started with Raynaud's in my fingers and toes when I was about nineteen years old, in 1979...
Rachelle: Endometriosis and Interstitial Cystitis I am just happy after two and a half years to know that I have a real answer and I can get better...
Fibromyalgia and Chronic Fatigue Syndrome
Fibromyalgia and Chronic Fatigue Syndrome Symptoms, diagnostic criteria, treatments and research for CFS and Fibromyalgia. ISN.
Relationship Between CFS/FMS
What is CFS?
What is Fibromyalgia?
Causes of CFS/FMS
CFS Causes
FMS Causes
Diagnosis of CFS/FMS
CFS Diagnosis
FMS Diagnosis
Treatments of CFS/FMS
CFS Treatments
FMS Treatments
Alternative and Nutritional
FMS General Management
FMS and Exercise
FMS Medications
Related Symptoms or Disorders
Autoimmune and Scleroderma
Gastrointestinal
Interstitial Cystitis (IC)
Lupus
Scleroderma
Temporomandibular Joint Disorder
Disability Info for CFS/FMS
Research about CFS/FMS
CFS Psychosocial Research
FMS Psychosocial Research
FMS Medical Research: Pain
Support for CFS/FMS
Personal Stories about CFS/FMS
Guillain-Barre Syndrome
Home Intravenous Immunoglobulin Therapy Safe in Patients With Neuroimmunological Disorders. Intravenous (IV) immunoglobulin therapy has a favourable safety profile for patients with neuroimmunological disorders such as Guillain-Barré Syndrome, chronic inflammatory demyelinating polyneuropathy, myasthaenia gravis, polymyositis, dermatomyositis, and multifocal motor neuropathy. Doctor's Guide Channel. 04/18/08. (Also see: IVIg and Dermatomyositis/Polymyositis)
Donna Jackson Nakazawa: Autoimmune diseases hazards. My paralysis was caused by Guillain-Barre syndrome, in which body's immune system destroys the nerves' myelin sheaths, short-circuiting messages from the brain to the muscles. Opinion. The Sacramento Bee. 03/19/08.
Intravenous immunoglobulin (IVIg) for Guillain-Barré syndrome. IVIg helps to speed recovery in adults and probably in children with severe Guillain-Barré syndrome. Guillain-Barré syndrome is an uncommon autoimmune disease of the peripheral nerves. It causes weakness, numbness and breathing difficulty. The Cochrane Database of Systematic Reviews 2006 Issue 1.
Do Bacteria or Viruses Cause MS? Though it hasn't been clear as to the cause of this immune system miscue, a new study from Switzerland suggests that a certain bacterium or virus may be the culprit. These bacterial infections, the Swiss study team claims, induce a kind of self-recognition that may contribute to some autoimmune diseases such as MS and Guillain-Barre syndrome (GBS). MS Neighborhood. 07/08/05. (Also see: Multiple Sclerosis)
Idiopathic Thromocytopenic Purpura
Costly IVIg could be replaced with synthetic blood product. Scientists are deciphering how a blood-derived product called intravenous immunoglobulin (IVIg) currently works, and as a result has developed a synthetic replacement product that shows promise in laboratory testing. Medical Research News. 06/01/06. (Also see: IVIg)
Idiopathic thrombocytopenic purpura is an autoimmune disease in which macrophages of reticuloendothelial system, mainly in the spleen, remove platelets covered by autoantibodies from circulation. By removing the spleen 60-80% of patients are cured. Partial remission is achieved in 10-20% cases. PubMed. Acta Chir Iugosl 2002;49(3):41-3.
Interstitial Cystitis
Interstitial Cystitis (bladder involvement) ISN.
What is Interstitial Cystitis?
IC and Autoimmune Diseases
IC and Fibromyalgia
Diagnosis
Treatments
Overactive Bladder
Sources
Patient Stories
Leukemia
It is rare, but scleroderma has been associated with Large Granular Lymphocyte Leukemia.Medscape.
Marfan syndrome (MFS)
Ehlers-Danlos syndromes and Marfan syndrome. Ehlers-Danlos syndromes (EDS) and Marfan syndrome (MFS) are multisystemic disorders that primarily affect the soft connective tissues. (ScienceDirect) Best Practice & Research Clinical Rheumatology Vol 22, Issue 1, March 2008, Pp 165-189. (Also see: EDS)
Mixed Connective Tissue Disease
Scleroderma in Overlap Scleroderma can occur in overlap with other autoimmune diseases, such as lupus, dermatomyositis or polymyosits, and rheumatoid arthritis. ISN.
Scleroderma in Overlap
Connective Tissue Disease (CTD)
MCTD
Multiple Autoimmune Syndrome
UCTD
Shared Autoimmunity
Overlap Patient Stories
See Also
Multiple Sclerosis
Multiple Sclerosis Topics include symptoms, overlap, treatments, research, support organizations, personal stories and media stories about MS. ISN.
Overview of Multiple Sclerosis
Symptoms of MS
Overlaps with MS
MS and Glandular Fever
MS and Scleroderma
Causes of MS
Treatments and Clinical Trials
MS Research
MS Research: Causes
Personal Stories About MS
Support Organizations
MS Media Stories
Myasthenia Gravis (MG)
Myasthenia gravis is a neuromuscular autoimmune disease that is sometimes associated with scleroderma or other autoimmune diseases. ISN.
What is Myasthenia Gravis?
Symptoms of MG
Pregnancy and MG
Scleroderma and MG
Treatments for MG
Research about MG
Personal Stories about MG
Neuromuscular Diseases
Neuromuscular diseases that may be associated with scleroderma include polymyositis, dermatomyositis, and inclusion body myositis. (Also see: Overlap Syndrome). ISN.
Pancytopenia
Pancytopenia is a medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets. Wikipedia.
Methotrexate-induced pancytopenia more common than expected. Virtual Rheumatology Centre, 08/06/05.
A case of Behcet's disease with esophageal ulcers complicated with systemic sclerosis, chronic hepatitis C, and pancytopenia. This is a rare case of Behcet's disease complicated with esophageal ulcers, systemic sclerosis, chronic hepatitis C, and pancytopenia. Of interest is the mechanism of coincidence of these diseases from the pathological point of view. PubMed. Nihon Rinsho Meneki Gakkai Kaishi. 2004 Jun;27(3):164-70. (Also see: Behcet's and Liver Involvement)
A case of scleroderma with pancytopenia due to lack of trace elements. As patients with scleroderma sometimes develop gastrointestinal problems and are needed intravenous nutrition of long duration, they should be paid attention to lack of trace elements that can be a cause of hematologic complications. PubMed. Ryumachi 2002 Dec;42(6):903-9. (Also see: Gastrointestinal Involvement)
Polyarteritis Nodosa (PAN)
Postirradiation morphea and subcutaneous polyarteritis nodosa: Case report and literature review. Postirradiation morphea is an uncommon condition but is being increasingly recognized. Radiation may be responsible for inducing some of the pathogenic changes seen in scleroderma and other autoimmune diseases. PubMed. Semin Arthritis Rheum. 2005 Apr;34(5):728-34. (Also see: Causes of Morphea and Causes of Scleroderma: Radiation)
Idiopathic myelofibrosis associated with classic polyarteritis nodosa. A woman with scleroderma and classic polyarteritis nodosa (PAN) who developed idiopathic myelofibrosis (IM) is reported. This case represents a new association between IM and an autoimmune disease and supports the hypothesis of an immune basis of IM in some patients. PubMed. Leuk Lymphoma 2003 Mar;44(3):539-41. (Also see: Overlap Syndrome)
Polymyositis
Dermatomyositis and Polymyositis. Polymyositis is very similar to dermatomyositis but without the rash. It causes inflammation and weakness of muscles and is sometimes associated with systemic scleroderma. ISN. (Also see: Types of Scleroderma and Overlap Syndrome)
Psoriasis and Psoriatic Arthritis
Psoriasis Health Center. WebMD.
What is Psoriasis and Psoriatic Arthritis?
Causes of Psoriasis
Complications of Psoriasis
Diagnosis of Psoriasis
Treatments for Psoriasis
Rheumatoid Arthritis
Rheumatoid Arthritis (RA) is a chronic autoimmune disease that primarily affects the joints. However, it may also cause anemia, eye inflammation, heart attacks, heart failure, myocarditis, pericarditis, pleurisy, vasculitis, shortness of breath, skin ulcers, stomach ulcers, strokes, and neuropathies (numbness and tingling). ISN.
Overview
Symptoms
Causes
Diagnosis
Antibodies
Scleroderma and Rheumatoid Arthritis
Prevention
Treatments
Research
Support
Personal Stories
Media Stories
Sarcoidosis, Sarcoiditis
What is Sarcoidosis? Sarcoidosis is an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands. In patients with sarcoidosis, abnormal masses or nodules (called granulomas) consisting of inflamed tissues form in certain organs of the body. Cleveland Clinic.
What is Sarcoidosis and Sarcoiditis?
Causes of Sarcoidosis
Diagnosis of Sarcoidosis
Symptoms of Sarcoidosis
Treating Sarcoidosis
Personal Stories
Systemic Lupus Erythematosus (SLE)
Systemic Lupus Erythematosus (SLE) is an autoimmune disease that can cause a multitude of symptoms. Lupus can occur in overlap with scleroderma and other autoimmune diseases. Scleroderma is also frequently misdiagnosed as lupus in its initial stages. ISN.
What is Lupus?
Symptoms of Lupus
Causes of Lupus
Diagnosis of Lupus
Antibodies in Lupus
Scleroderma and Lupus
Prevention of Lupus
Treatments for Lupus
Research About Lupus
Support for Lupus
Personal Stories about Lupus
Lupus Media Stories
Thrombotic Thrombocytopenic Purpura (TTP)
Thrombotic thrombocytopenic purpura (TTP) mimicking acute ischemic stroke. TTP is an autoimmune disorder characterised by thrombocytopenia, haemolytic anemia, fluctuating neurological deficits, fever, and renal impairment. PubMed. Emerg Med J. 2006 Sep;23(9):e51. (Also see: Cardiac Involvement: Stroke)
Thrombotic thrombocytopenic purpura (TTP) in the setting of systemic sclerosis (SSc). The diagnosis of TTP, and the distinction from scleroderma renal crisis (SRC), may be challenging. However, the correct diagnosis is critical because treatment differs substantially for each of these life-threatening conditions. PubMed. Semin Arthritis Rheum. 2005 Feb;34(4):683-8. (Also see: Kidney Involvement)
Thyroid: Hashimoto's Thyroiditis and Graves Disease
Thyroid: Graves' Disease and Hashimoto's Thyroiditis. It is common for people with scleroderma to also have other health problems, such as thyroid disease. The two main types of thyroid disease fall into hyperthyroidism (Grave's disease), and hypothyroidism (Hashimoto's thyroiditis). ISN.
Overview of Thyroid Disease
Graves' Disease
Overview of Graves Disease'
Research of Graves' Disease
Hashimoto's Thyroiditis
Overview of Hashimoto's

Research of Hashimoto's
Thyroid Research Articles
Thyroid Patient Education and Support
Thyroid Personal Stories

Tuberculosis and Scleroderma
What is Tuberculosis? Tuberculosis is a bacterial disease usually affecting the lungs (pulmonary TB). Other parts of the body can also be affected, for example lymph nodes, kidneys, bones, joints, etc. (extrapulmonary TB). New York State Department of Health.
Scleroderma concurrent with culture proven tuberculosis in a Japanese Canadian patient. We describe a Japanese Canadian woman who presented with scleroderma and tuberculosis. We discuss the possible association between these 2 diseases. J Rheumatol. 1996 Dec;23(12):2168-70.
Silica-dust-exposed mine workers with scleroderma (systemic sclerosis). There was a significant increase in the prevalence of tuberculosis in the past in the group with scleroderma, compared with a group of men with silicosis from the same population. The nature of the association of tuberculosis with scleroderma has not been defined. Chest, Vol 92, 260-262, 1987. (Also see: Causes of Scleroderma: Silica)
Tuberculous Fasciitis in Scleroderma
Tuberculous fasciitis in scleroderma. We here report a case of tuberculous fasciitis manifest with painful swelling of the midposterior muscles of the right thigh without pulmonary tuberculosis in a patient with scleroderma. PubMed. Clin Rheumatol. 2004 Feb;23(1):66-8.
Undifferentiated Connective Tissue Disease
Undifferentiated Connective Tissue Disease (UCTD) ISN.
Scleroderma in Overlap
Connective Tissue Disease (CTD)
MCTD
Multiple Autoimmune Syndrome
UCTD
Shared Autoimmunity
Overlap Patient Stories
See Also
Vasculitis
Vasculitis is an inflammation of blood vessels, which can affect many different parts of the body. Sometimes it occurs along with illnesses like lupus or scleroderma. ISN.
What is Vasculitis?
Symptoms of Vasculitis
Photos of Vasculitis
Causes of Vasculitis
Diagnosis of Vasculitis
Scleroderma and Vasculitis
Treatments for Vasculitis
Personal Stories about Vasculitis
Vulvodynia
Vulvodynia Vaginal pain can occur in Scleroderma patients from Sjögren's causing excessive vaginal dryness. National Vulvodynia Association.
Wegener's Granulomatosis
Results of endoscopic surgery and intralesional steroid therapy for airway compromise due to tracheobronchial Wegener's granulomatosis(WG). Intralesional steroid therapy and conservative endoluminal surgery is an effective strategy for treating airway compromise due to active tracheal and bronchial WG, obviating the need for airway bypass or stenting. S. A. R. Nouraei. European Respiratory Review, 2008;17: 30-32. (Also see: Vasculitis)
Wegener’s Granulomatosis Occurring In Father and Son. Wegener’s Granulomatosis (WG) is a rare necrotising vasculitis. There is an ongoing debate regarding the importance of genetics and environment in the aetiology of WG. Our case report of Wegener’s Granulomatosis in a father and son supports the anecdotal evidence for genetic influences. Medicine On-Line. International Journal of Medicine. 05/03/07. (Also see: Vasculitis)
Systemic autoimmune diseases form a diverse group which includes: systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD), scleroderma, dermato-polymyositis, Wegener's granulomatosis, Sjogren syndrome. The frequency and extent of cardiac pathology positively correlated with the detection of antiphospholipid antibodies. No such relationship was observed in patients with the presence of very high titers of antinuclear antibodies (anti-dsDNA). PubMed. Pol Arch Med Wewn. 2003 Apr;109(4):375-81.
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