| Associated
Conditions: MAIN MENU |
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| ASSOCIATED
CONDITIONS: MAIN MENU |
| It is common for people with scleroderma to also have other health problems, and here are a few items often associated with it. Just because something is listed here does not mean an individual patient will ever experience it. See Disclaimer. |
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| Anemia of Chronic
Disease |
| Anemia
of Chronic Disease. Anemia refers to a deficiency in
the blood. Anemia most commonly refers to insufficient iron
resulting in a shortage of hemoglobin, but the term is also
used to indicate vitamin deficiency or blood loss. Anemia
can range from mild and temporary to severe and life-threatening.
When the anemia is caused by a chronic illness, it is called "anemia
of chronic disease." ISN. |
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| Antiphospholipid Syndrome |
| Antiphospholipid
Syndrome Symptoms include deep vein thrombosis,
chronic leg ulcers, recurrent miscarriages, headache, heart
attacks, renal vein and artery thrombosis, pulmonary embolism,
and pulmonary hypertension. It is identified by the presence
of anticardiolipin antibodies, in a blood test. The same
antibodies have been associated with generalized morphea
scleroderma. ISN. |
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| Arthritis |
| Scleroderma is classified as an
arthritic disease, along with rheumatoid arthritis, lupus,
dermatomyositis, and more than 100 other medical conditions.. |
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| Asthma |
| Asthma
Risk Related To Decreased Fruit and Vitamin C consumption. A
new study indicates that people suffering from symptomatic
asthma eat less fruit and have decreased intake of vitamin
C and manganese than their counterparts without the problem. News
for the Day. 05/21/06. 1193. |
| The
Relation Between Gastroesophageal Reflux and Respiratory
Symptoms in a Population-Based Study. Reflux symptoms commonly
coexist with asthma and other respiratory symptoms on a population-based
level, seemingly irrespective of asthma medication. Chest.
2006;129:1051-1056. . (Also see: Heartburn) |
| A
new view of Asthma's cause. Previously unrecognized immune
cell may provide a better target for Asthma therapy. They
examined specimens from the lungs of 25 adults: 14 with moderate-to-severe
bronchial asthma, 6 healthy subjects and 5 patients with
sarcoidosis, a respiratory inflammatory disease. eMaxHealth.com.
03/16/06. |
| Autoimmune Ear Disease |
| Autoimmune
Ear Disease ISN. |
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| Autoimmunity |
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| Behcet's |
| Behcet's disease is a type of vasculitis characterized by mouth sores, genital sores, inflammation inside of the eye, skin problems, and arthritis (swelling of the joints).The disease usually affects more men than women. The disease appears to be more severe in young, male, and Middle Eastern or Far Eastern patients. Vasculitis Foundation. |
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| Cancer |
| Scleroderma
and Cancer. Systemic sclerosis (scleroderma) may be associated
with an increased incidence of cancer, including breast cancer,
B-cell lymphoma, lung cancer and tongue cancer. ISN |
|
| Celiac Disease and Gluten Sensitivity |
| Celiac Disease and Gluten Sensitivity. Celiac disease is a known cause of scleroderma and dozens of other autoimmune diseases, including Hashimoto's thyroiditis, psoriasis, and Sjogren's syndrome. ISN. |
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| Chronic Fatigue Syndrome
(CFS) |
| Chronic
Fatigue Syndrome Symptoms, diagnostic criteria, treatments
and research for CFS and Fibromyalgia. ISN. |
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| Depression |
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| Dermatology (General) |
| Dermatology a
great site. DermWeb. |
| Skin
and Connective Tissue Diseases Karolinska Institutet,
Sweden. |
| Dermatomyositis and
Polymyositis |
| Dermatomyositis
and Polymyositis. Polymyositis is an inflammatory condition
of the muscles; dermatomyositis is an inflammatory
condition of the skin and muscles, which causes a
distinctive rash. ISN. |
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| Diabetes |
| Diabetes.
Topics include symptoms, causes, diagnosis, treatments, research,
personal stories and media stories about diabetes. ISN. |
|
|
| Ehlers-Danlos syndrome (EDS) |
| Ehlers-Danlos syndromes and Marfan syndrome. Ehlers-Danlos syndromes (EDS) and Marfan syndrome (MFS) are multisystemic disorders that primarily affect the soft connective tissues. (ScienceDirect) Best Practice & Research Clinical Rheumatology Vol 22, Issue 1, March 2008, Pp 165-189. (Also see: MFS) |
| Endometriosis |
| Pathogenesis
of endometriosis: natural immunity dysfunction or autoimmune
disease? Recently, endometriosis has also been considered
to be an autoimmune disease, owing to the presence of autoantibodies,
the association with other autoimmune diseases and recurrent
immune-mediated abortion. These findings are in apparent
contradiction with the reduced cell-mediated natural immunity
observed during the disease. PubMed. Trends Mol Med 2003
May;9(5):223-228. |
| March
is Endometriosis Awareness Month. Endometriosis is a
painful reproductive and immunological disease in which uterine
lining migrates outside the uterus, implants in other areas
of the body and abnormally grows. eMediaWire 03/03/05. |
| Krisha
S: Multiple Autoimmune Condition I have endometriosis,
multiple sclerosis (MS), fibromyalgia, and Stiff Person Syndrome... |
| Kym:
Diffuse, CREST Scleroderma, Lupus and Fibromyalgia It
all started with Raynaud's in my fingers and toes when I
was about nineteen years old, in 1979... |
| Rachelle:
Endometriosis and Interstitial Cystitis I am just
happy after two and a half years to know that I have a real
answer and I can get better... |
| Fibromyalgia and Chronic
Fatigue Syndrome |
| Fibromyalgia
and Chronic Fatigue Syndrome Symptoms, diagnostic criteria,
treatments and research for CFS and Fibromyalgia. ISN. |
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|
| Guillain-Barre Syndrome |
| Home Intravenous Immunoglobulin Therapy Safe in Patients With Neuroimmunological Disorders. Intravenous (IV) immunoglobulin therapy has a favourable safety profile for patients with neuroimmunological disorders such as Guillain-Barré Syndrome, chronic inflammatory demyelinating polyneuropathy, myasthaenia gravis, polymyositis, dermatomyositis, and multifocal motor neuropathy. Doctor's Guide Channel. 04/18/08. (Also see: IVIg and Dermatomyositis/Polymyositis) |
| Donna Jackson Nakazawa: Autoimmune diseases hazards. My paralysis was caused by Guillain-Barre syndrome, in which body's immune system destroys the nerves' myelin sheaths, short-circuiting messages from the brain to the muscles. Opinion. The Sacramento Bee. 03/19/08. |
| Intravenous immunoglobulin (IVIg) for Guillain-Barré syndrome. IVIg
helps to speed recovery in adults and probably in children
with severe Guillain-Barré syndrome. Guillain-Barré syndrome
is an uncommon autoimmune disease of the peripheral nerves.
It causes weakness, numbness and breathing difficulty. The
Cochrane Database of Systematic Reviews 2006 Issue 1. |
| Do
Bacteria or Viruses Cause MS? Though it hasn't been
clear as to the cause of this immune system miscue, a new
study from Switzerland suggests that a certain bacterium
or virus may be the culprit. These bacterial infections,
the Swiss study team claims, induce a kind of self-recognition
that may contribute to some autoimmune diseases such as
MS and Guillain-Barre syndrome (GBS). MS Neighborhood. 07/08/05. (Also see: Multiple
Sclerosis) |
| Idiopathic Thromocytopenic
Purpura |
| Costly
IVIg could be replaced with synthetic blood product. Scientists
are deciphering how a blood-derived product called intravenous
immunoglobulin (IVIg) currently works, and as a result has
developed a synthetic replacement product that shows promise
in laboratory testing. Medical Research News. 06/01/06.
(Also see: IVIg) |
| Idiopathic
thrombocytopenic purpura is an autoimmune disease in which
macrophages of reticuloendothelial system, mainly in the
spleen, remove platelets covered by autoantibodies from circulation. By
removing the spleen 60-80% of patients are cured. Partial
remission is achieved in 10-20% cases. PubMed. Acta Chir
Iugosl 2002;49(3):41-3. |
| Interstitial Cystitis |
| Interstitial
Cystitis (bladder involvement) ISN. |
|
|
| Leukemia |
| It is rare, but scleroderma has
been associated with Large Granular Lymphocyte Leukemia.Medscape. |
| Marfan syndrome (MFS) |
| Ehlers-Danlos syndromes and Marfan syndrome. Ehlers-Danlos syndromes (EDS) and Marfan syndrome (MFS) are multisystemic disorders that primarily affect the soft connective tissues. (ScienceDirect) Best Practice & Research Clinical Rheumatology Vol 22, Issue 1, March 2008, Pp 165-189. (Also see: EDS) |
| Mixed Connective Tissue
Disease |
| Scleroderma
in Overlap Scleroderma can occur in overlap with other
autoimmune diseases, such as lupus, dermatomyositis or polymyosits,
and rheumatoid arthritis. ISN. |
|
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| Multiple Sclerosis |
| Multiple
Sclerosis Topics include symptoms, overlap, treatments,
research, support organizations, personal stories and media
stories about MS. ISN. |
|
| Myasthenia Gravis
(MG) |
| Myasthenia
gravis is a neuromuscular autoimmune disease that is
sometimes associated with scleroderma or other autoimmune
diseases. ISN. |
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|
| Neuromuscular Diseases |
| Neuromuscular diseases that may
be associated with scleroderma include polymyositis, dermatomyositis,
and inclusion
body myositis. (Also see: Overlap
Syndrome). ISN. |
| Pancytopenia |
| Pancytopenia is
a medical condition in which there is a reduction in the number
of red and white blood cells, as well as platelets. Wikipedia. |
| Methotrexate-induced
pancytopenia more common than expected. Virtual Rheumatology
Centre, 08/06/05. |
| A
case of Behcet's disease with esophageal ulcers complicated
with systemic sclerosis, chronic hepatitis C, and pancytopenia. This
is a rare case of Behcet's disease complicated with esophageal
ulcers, systemic sclerosis, chronic hepatitis C, and pancytopenia.
Of interest is the mechanism of coincidence of these diseases
from the pathological point of view. PubMed. Nihon Rinsho
Meneki Gakkai Kaishi. 2004 Jun;27(3):164-70. (Also see: Behcet's and Liver
Involvement) |
| A
case of scleroderma with pancytopenia due to lack of trace
elements. As patients with scleroderma sometimes develop
gastrointestinal problems and are needed intravenous nutrition
of long duration, they should be paid attention to lack of
trace elements that can be a cause of hematologic complications. PubMed.
Ryumachi 2002 Dec;42(6):903-9. (Also see: Gastrointestinal
Involvement) |
| Polyarteritis Nodosa
(PAN) |
| Postirradiation
morphea and subcutaneous polyarteritis nodosa: Case report
and literature review. Postirradiation morphea is an
uncommon condition but is being increasingly recognized.
Radiation may be responsible for inducing some of the pathogenic
changes seen in scleroderma and other autoimmune diseases. PubMed.
Semin Arthritis Rheum. 2005 Apr;34(5):728-34. (Also see: Causes
of Morphea and Causes
of Scleroderma: Radiation) |
| Idiopathic
myelofibrosis associated with classic polyarteritis nodosa. A
woman with scleroderma and classic polyarteritis nodosa (PAN)
who developed idiopathic myelofibrosis (IM) is reported.
This case represents a new association between IM and an
autoimmune disease and supports the hypothesis of an immune
basis of IM in some patients. PubMed. Leuk Lymphoma 2003
Mar;44(3):539-41. (Also see: Overlap
Syndrome) |
| Polymyositis |
| Dermatomyositis
and Polymyositis. Polymyositis is very similar to dermatomyositis
but without the rash. It causes inflammation and weakness
of muscles and is sometimes associated with systemic scleroderma. ISN.
(Also see: Types
of Scleroderma and Overlap
Syndrome) |
| Psoriasis and Psoriatic
Arthritis |
| Psoriasis Health Center. WebMD. |
|
| Rheumatoid Arthritis |
| Rheumatoid
Arthritis (RA) is a chronic autoimmune disease that primarily
affects the joints. However, it may also cause anemia, eye
inflammation, heart attacks, heart failure, myocarditis,
pericarditis, pleurisy, vasculitis, shortness of breath,
skin ulcers, stomach ulcers, strokes, and neuropathies (numbness
and tingling). ISN. |
|
|
| Sarcoidosis, Sarcoiditis |
| What
is Sarcoidosis? Sarcoidosis is an inflammatory disease
that affects multiple organs in the body, but mostly the
lungs and lymph glands. In patients with sarcoidosis, abnormal
masses or nodules (called granulomas) consisting of inflamed
tissues form in certain organs of the body. Cleveland Clinic. |
|
| Systemic Lupus Erythematosus
(SLE) |
| Systemic
Lupus Erythematosus (SLE) is an autoimmune disease that
can cause a multitude of symptoms. Lupus can occur in overlap
with scleroderma and other autoimmune diseases. Scleroderma
is also frequently misdiagnosed as lupus in its initial stages. ISN. |
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|
| Thrombotic Thrombocytopenic
Purpura (TTP) |
| Thrombotic
thrombocytopenic purpura (TTP) mimicking acute ischemic stroke. TTP
is an autoimmune disorder characterised by thrombocytopenia,
haemolytic anemia, fluctuating neurological deficits, fever,
and renal impairment. PubMed. Emerg Med J. 2006
Sep;23(9):e51. (Also see: Cardiac
Involvement: Stroke) |
| Thrombotic
thrombocytopenic purpura (TTP) in the setting of systemic
sclerosis (SSc). The diagnosis of TTP, and the distinction
from scleroderma renal crisis (SRC), may be challenging.
However, the correct diagnosis is critical because treatment
differs substantially for each of these life-threatening
conditions. PubMed. Semin Arthritis Rheum. 2005 Feb;34(4):683-8.
(Also see: Kidney
Involvement) |
| Thyroid: Hashimoto's
Thyroiditis and Graves Disease |
| Thyroid:
Graves' Disease and Hashimoto's Thyroiditis. It is common
for people with scleroderma to also have other health problems,
such as thyroid disease. The
two main types of thyroid disease fall into hyperthyroidism
(Grave's disease), and hypothyroidism (Hashimoto's thyroiditis). ISN. |
|
|
| Tuberculosis and Scleroderma |
| What
is Tuberculosis? Tuberculosis is a bacterial disease
usually affecting the lungs (pulmonary TB). Other parts of
the body can also be affected, for example lymph nodes, kidneys,
bones, joints, etc. (extrapulmonary TB). New York State
Department of Health. |
| Scleroderma
concurrent with culture proven tuberculosis in a Japanese
Canadian patient. We describe a Japanese Canadian woman
who presented with scleroderma and tuberculosis. We discuss
the possible association between these 2 diseases. J Rheumatol.
1996 Dec;23(12):2168-70. |
| Silica-dust-exposed
mine workers with scleroderma (systemic sclerosis). There
was a significant increase in the prevalence of tuberculosis
in the past in the group with scleroderma, compared with
a group of men with silicosis from the same population. The
nature of the association of tuberculosis with scleroderma
has not been defined. Chest, Vol 92, 260-262, 1987. (Also see: Causes of Scleroderma: Silica) |
| Tuberculous Fasciitis
in Scleroderma |
| Tuberculous
fasciitis in scleroderma. We here report a case of tuberculous
fasciitis manifest with painful swelling of the midposterior
muscles of the right thigh without pulmonary tuberculosis
in a patient with scleroderma. PubMed. Clin Rheumatol.
2004 Feb;23(1):66-8. |
| Undifferentiated Connective
Tissue Disease |
| Undifferentiated
Connective Tissue Disease (UCTD) ISN. |
|
|
| Vasculitis |
| Vasculitis is
an inflammation of blood vessels, which can affect many different
parts of the body. Sometimes it occurs along with illnesses
like lupus or scleroderma. ISN. |
|
|
| Vulvodynia |
| Vulvodynia Vaginal
pain can occur in Scleroderma patients from Sjögren's causing
excessive vaginal dryness. National Vulvodynia Association. |
| Wegener's Granulomatosis |
| Results of endoscopic surgery and intralesional steroid therapy for airway compromise due to tracheobronchial Wegener's granulomatosis(WG). Intralesional steroid therapy and conservative endoluminal surgery is an effective strategy for treating airway compromise due to active tracheal and bronchial WG, obviating the need for airway bypass or stenting. S. A. R. Nouraei. European Respiratory Review, 2008;17: 30-32. (Also see: Vasculitis) |
| Wegener’s Granulomatosis Occurring In Father and Son. Wegener’s Granulomatosis (WG) is a rare necrotising vasculitis. There is an ongoing debate regarding the importance of genetics and environment in the aetiology of WG. Our case report of Wegener’s Granulomatosis in a father and son supports the anecdotal evidence for genetic influences. Medicine On-Line. International Journal of Medicine. 05/03/07. (Also see: Vasculitis) |
| Systemic
autoimmune diseases form a diverse group which includes:
systemic lupus erythematosus (SLE), mixed connective tissue
disease (MCTD), scleroderma, dermato-polymyositis, Wegener's
granulomatosis, Sjogren syndrome. The frequency and extent
of cardiac pathology positively correlated with the detection
of antiphospholipid antibodies. No such relationship was
observed in patients with the presence of very high titers
of antinuclear antibodies (anti-dsDNA). PubMed. Pol Arch
Med Wewn. 2003 Apr;109(4):375-81. |
| Footnotes |
| (1) Medscape requires (free) sign
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