Dermatomyositis and Polymyositis (DM/PM) |
| Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer |
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Myopathy and Myositis |
| Myopathy vs. Myositis. Myopathy means muscle disease. Myositis means muscle disease that is caused by inflammation. There are three types of myositis: dermatomyositis, polymyositis, and inclusion body myositis. ISN. |
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What is Dermatomyositis? |
| Inflammatory muscle weakness plus skin rashes |
| Dermatomyositis is an inflammatory skin and muscle disease. Distinctive rashes on the hands, feet, elbows, face, and/or upper body, occurring along with muscle weakness, are hallmark symptoms. (Also see: Autoimmune Diseases) |
| Dermatomyositis. "Dermatomyositis is an acute inflammatory condition of skin and muscle." Dr. Thomas Lehman. |
| What is Dermatomyositis? National Institute of Neurological Disorders and Stroke. |
| Sun Exposure May Trigger Certain Autoimmune Diseases in Women. This study found that women who lived in areas with higher levels of UV exposure when they developed an autoimmune muscle disease called myositis were more likely to develop the form known as dermatomyositis, which weakens the muscles and causes distinctive rashes, instead of the form called polymyositis that does not have a rash. NIH News. 07/30/09. |
What is Polymyositis? |
| Inflammatory muscle weakness without skin rashes |
| Polymyositis is an inflammatory muscle disease. It's hallmark symptom is extreme muscle weakness, usually in the neck, upper arms, and thighs. When polymyositis occurs along with a skin rash, it is called dermatomyositis. |
| What is Polymyositis? It is a muscle disease featuring inflammation of the muscle fibers, typically those closest to the trunk or torso. This results in weakness that can be severe. MedicineNet.com. |
| C1D is a major autoantibody target in patients with the polymyositis-scleroderma overlap syndrome. Our results demonstrate that the recently identified exosome-associated protein C1D is a major autoantigen in patients with the PM-scleroderma overlap syndrome and suggest that the use of recombinant C1D as an autoantibody target may aid in diagnosis of the PM-scleroderma overlap syndrome. Arthritis and Rheumatism. Volume 56, Issue 7, Pages 2449 - 2454. (Also see: Antibodies and Overlap Syndrome) |
Symptoms of Dermatomyositis and Polymyositis |
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Diagnosis of Dermatomyositis and Polymyositis |
| Unusually High Prevalence Of Anti-Mi-2 Autoantibodies Associated With Severe Myositis In Mexican Patients With Dermatomyositis. Anti-Mi-2 had a high prevalence in Mexican PM/DM and it was associated with DM, male gender, weight loss, and shawl sign. DM patients with anti-Mi-2 had more severe myositis evidenced by higher levels of muscle enzymes than those without anti-Mi-2. M. Petri. EULAR 2011 SAT0419. Ann Rheum Dis 2011;70(Suppl3):659. |
| Imaging tools for the clinical assessment of idiopathic inflammatory myositis. In suspected myositis, muscle imaging should be strongly considered prior to obtaining a muscle biopsy. Future research should prospectively study the use of muscle imaging in the evaluation of treatment response and muscle function. (PubMed) Walker UA. Curr Opin Rheumatol. November 2008. |
Mortality and Prognosis of DM/PM |
| Trends in dermatomyositis (DM) - and polymyositis (PM) -related mortality in the state of Sao Paulo, Brazil, 1985-2007: multiple cause-of-death analysis. For DM/PM, respectively, as associated causes, the following were the principal underlying causes of death: respiratory disorders (in 28.3%/26.0%); circulatory disorders (in 17.4%/20.5%); neoplasms (in 16.7%/13.7%); infectious and parasitic diseases (in 11.6%/9.6%); and gastrointestinal disorders (in 8.0%/4.8%). Augusto Santo. (7th Space) BMC Public Health 2010, 10:597. |
Treatments for Dermatomyositis and Polymyositis |
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Research about Dermatomyositis and Polymyositis |
| Cutting Edge Issues in Polymyositis. Activation of endoplasmic reticulum stress response due to muscle regeneration and inflammation but independent to MHC-1 up-regulation has been recently reported in patients with myositis. Ghirardello A. (PubMed) Clin Rev Allergy Immunol. 2010 Dec 30. |
| A case of polymyositis and vasculitis induced by ovulation induction therapy with gonadotropin-releasing hormone (GnRH). We report a case of vasculitis and histologically proven severe polymyositis developed 5 days after GnRH administration due to ovulation induction in an infertile patient with no previous history of autoimmune diseases. (SpringerLink) I. Lazu'rova'. Clinical Rheumatology. May 2 2010. (Also see: Vasculitis) |
| Graft-versus-host disease (GVHD) related polymyositis. Chronic GVHD sometimes mimics autoimmune diseases. We report the case of a 39-year-old patient who presented atypical polymyositis without elevated creatinine phosphokinase, related to a chronic GVHD following interruption of immunosuppressive treatment. (SpringerLink) H. Maillard – Lefebvre. January 13 2010. (Also see: GVHD). |
| Dermatomyositis and HIV infection: case report and review of the literature. Given the broad effects of this virus on both the humoral and cell-mediated arms of the immune system, illnesses such as polymyositis and Reiter's syndrome appear to be more prevalent in HIV-infected individuals and occur in the absence of well-described predispositions. (PubMed) MB Carroll. Rheumatol Int. October 24 2009. |
| Polymyositis: Can a gluten-free diet reduce symptoms? If you have polymyositis — a rare connective tissue disease — you may be at increased risk of celiac disease. In such cases, a gluten-free diet can improve signs and symptoms of celiac disease. But there's no evidence that a gluten-free diet can improve signs and symptoms of polymyositis. Mayo Clinic. (Also see: Celiac Disease and Gluten Sensitivity) |
