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Autoimmune Diseases: Diabetes
Janey Willis Hello, I am Janey Willis, ISN Guide to Diabetes. Type 1 Diabetes is an autoimmune disease, and Type 2 Diabetes is caused by risk factors such as lifestyle, ethnicity, age, and pregnancy. The majority of people with diabetes are Type 2. This page has not yet been medically edited. Just because something is listed here does not mean an individual patient will ever experience it. See Disclaimer.
Overview of Diabetes
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Scleroderma and Diabetes
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Scleroderma and Diabetes
Overview of Scleroderma and Diabetes
Scleroderma and Diabetes
Scleredema Adultorum Buschke
Overview of Scleroderma and Diabetes

Diabetes Mellitus (Type 1) and systemic sclerosis (scleroderma) are both autoimmune diseases.

Genes associated with scleroderma suggest that there is increased susceptibility to autoimmunity, as chromosomal region 1q42 has also been linked to lupus (SLE), rheumatoid arthritis (RA), and Type 1 Diabetes.

Diabetics can also develop skin complications that resemble systemic sclerosis (scleroderma) or Scleredema adultorum Buschke.

Scleroderma and Diabetes
Soft tissue calcifications in the lower extremities of severely diabetic patients simulating venous stasis or collagen vascular disease. Patients with severe diabetes mellitus may exhibit soft tissue calcifications of their lower extremities that may simulate the changes of venous stasis or scleroderma.PubMed. Emerg Radiol. 2006 Oct 10. (Also see: Calcinosis
Scleredema and diabetic sclerodactyly. It is important to distinguish between diabetic thick skin and scleroderma because scleroderma may also present with sclerodactyly and diffuse or localized thickening of the skin. Dermatology Online Journal. Dermatology Online Journal 11 (4): 3, 2005.
Candidate Gene Regions Associated with Systemic Sclerosis (SSc): A Family-Based Association Study Using TDT Analysis. These data from a general SSc population confirm genetic associations previously reported in the Choctaw. The association of SSc with chromosomal region 1q42 suggests that a gene (or genes) in this area confer(s) a more generalized susceptibility to autoimmunity because this region has also been linked to SLE, RA, and type I diabetes. Maureen D. Mayes. ACR Conference Oct. 2003.
The Effect of Nonmalignant Systemic Disease on Tolerance to Radiation Therapy. Collagen vascular disease and inflammatory bowel disease are considered relative contraindications for radiotherapy. Common diseases, like diabetes mellitus and hypertension, also represent management quandaries inasmuch as some reports also implicate these prevalent diseases with reduced tolerance to radiotherapy. Although the literature is sparse and retrospective in nature, the association of these diseases with radiation tolerance should no longer be regarded as anecdotal. The Oncologist, Vol. 7, No. 2, 136-143, April 2002. (Also see: Scleroderma and Radiation and Scleroderma and Cancer)
Scleredema Adultorum Buschke
Scleredema and diabetic sclerodactyly. Scleredema and diabetic sclerodactyly are both well recognized skin findings that may occur in patients with diabetes mellitus. PubMed. 2005 Dec 30. (Also see: Scleredema Adultorum Buschke)
Scleredema is an uncommon condition of unknown etiology characterized by nonpitting induration of the skin with occasional erythema. It may be associated with a history of an antecedent febrile illness, diabetes mellitus or the development of a blood dyscrasia. eMedicine Journal 8/02/01. (Also see: Scleredema Adultorum Buschke)
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