| Associated Conditions: MAIN MENU | |
|
| Systemic Lupus Erythematosus (SLE) |
| This page was written by Shelley Ensz, and has not yet been medically edited. See Disclaimer. |
|
|
|
| What is Systemic Lupus Erythematosus (SLE)? |
| Systemic Lupus Erythematosus (SLE) is an autoimmune disease that can cause a multitude of symptoms. Lupus can occur in overlap with scleroderma and other autoimmune diseases. Scleroderma is also frequently misdiagnosed as lupus in its initial stages. (Also see: Autoimmune Diseases, Difficult Diagnosis, What is Scleroderma?, and Overlap Syndrome) |
| Systemic Lupus Erythematosus (SLE/LUPUS). MedicineNet. |
| Types of Lupus. The various types of lupus include Cutaneous Lupus, Systemic Lupus (SLE), Drug- Induced Lupus; Overlap Syndrome; and Neonatal Lupus (rare). Lupus Foundation of America (Also see: Overlap Syndrome) |
| Do Improved Survival Rates of Patients with Systemic Lupus Erythematosus (SLE) Reflect a Global Trend? Despite the improvement in survival rates for patients with SLE the standardized mortality ratios are still 3-fold higher than for the general population. M. Abu-Shakra, MD. The Journal of Rheumatology. October 2008. |
| Symptoms of Lupus and Complications |
|
|
| Causes of Lupus |
| Causes of Lupus. ISN. |
| Diagnosis of Lupus |
| Diagnosis of Lupus. ISN. |
| Diet and Nutrition for Lupus |
| Diet and Nutrition. In general, you should try to eat a nutritious, well-balanced, and varied diet that contains plenty of fresh fruits and vegetables, whole grains, moderate amounts of meats, poultry, and oily fish, as fish oil has been found to help reduce inflammation. Lupus Foundation. 2009. |
| Antibodies in Lupus |
| Antibodies in Lupus. There are over 100 antibodies associated with lupus. ISN. |
| Scleroderma and Lupus |
| Overlap Syndrome : When lupus appears along with other autoimmune diseases such as scleroderma and polymyositis, it is called Overlap Syndrome. ISN. |
| Sclerodermiform linear lupus erythematosus: A distinct entity or coexistence of two autoimmune diseases? A Case Report. The coexistence of features of chronic cutaneous lupus erythematosus and scleroderma in the same skin lesions is very infrequent and has only been reported in 3 patients. Journal of the American Academy of Dermatology Vol 58, Issue 4, April 2008, Pp 665-667. (Also see: Overlap) |
| Systemic Sclerosis and Systemic Lupus Erythematosus have Distinct Gene Expression Profiles in the Peripheral Blood Cells. These data show that a limited number of genes reliably distinguished SSc from SLE. Shervin Assassi. 38/38. ACR 2007. (Also see: Scleroderma in Overlap) |
| Sclerodermic linear lupus panniculitis: report of two cases. Lupus erythematosus panniculitis is a rare disease characterized by deep subcutaneous nodules, most commonly localized on the upper limbs and face. We present here the clinical characteristics, course and laboratory findings of 2 patients having linear lupus erythematosus panniculitis with localized scleroderma-like changes. PubMed. Dermatology. 2005;210(4):329-32. (Also see: Linear Scleroderma, and Overlap Syndrome) |
| Lupus and Overlapping Diseases |
| Secondary Sjögren's Syndrome (SS) in Systemic Lupus Erythematosus (SLE) Defines a Distinct Disease Subset. The subset of patients with SLE and SS has a distinct clinical and laboratory phenotype, with a higher frequency of older white women with photosensitivity, oral ulcers, Raynaud’s phenomenon, anti-Ro antibodies, and anti-La antibodies and a lower frequency of renal disease, anti-dsDNA antibodies, and anti-RNP antibodies. A. Baer. JRheum. April 1 2010. (Also see: Sjögren's) |
| Epstein–Barr virus (EBV) -associated infectious mononucleosis (IM) and risk of systemic lupus erythematosus (SLE). EBV-associated IM does not seem to be a risk factor for SLE. C.J. Ulff-Moller. Rheumatology Advance Access. May 20, 2010. |
| Sjögren's syndrome (SS) -onset lupus (SLE) patients have distinctive clinical manifestations and benign prognosis: A case control study. Different from SLE-only patients, SS/SLE patients have distinctive clinical manifestations and benign prognosis that require less vigorous treatment with glucocorticoids and/or immunosuppressants. D. Xu. Lupus. February 1, 2010. (Also see: Sjogren's) |
| Pancreatitis in Systemic Lupus Erythematosus (SLE): Frequency and Associated Factors - A Review of the Hopkins Lupus Cohort. Hypertriglyceridemia appears to be a strong associate of pancreatitis in SLE, but antiphospholipid antibodies are not. SLE patients with psychosis and pleurisy are at increased risk for pancreatitis. A. Mikol. JRheum. December 23, 2009. |
| Thyroid Cancer in Systemic Lupus Erythematosus (SLE): A Case-Control Study. These data suggest that the prevalence of papillary thyroid cancer in SLE patients is higher than in age-matched controls, particularly in patients with thyroid autoimmunity. A. Antonelli. The Journal of Clinical Endocrinology & Metabolism. November 11, 2009. |
| Prevalence, predictors and outcome of vascular damage in systemic lupus erythematosus (SLE). Vascular events (VE) occurred in 26% of SLE patients, predominantly as atherothrombotic disease. VE prevalence increased linearly over time leading to a four-fold risk of mortality. (SageJournals) A. Becker-Merok. Lupus. Vol. 18, No. 6, 508-515. April 2009. (Also see: Vasculitis) |
| Active and Latent Tuberculosis (TB) in Patients With Systemic Lupus Erythematosus (SLE) Living in the United States. This study documents the demographic, clinical, and laboratory characteristics and outcomes of patients with SLE and latent tuberculosis infection (LTBI) or active TB in an ethnically diverse clinic. A significant number of patients with SLE in a county clinic population in the United States had LTBI or TB. A. Chu, MD. Journal of Clinical Rheumatology. August 2009. |
| Systemic Autoimmune Diseases (SAD) in Patients with Hepatitis C Virus (HCV) Infection: Characterization of 1020 Cases (The HISPAMEC Registry). In the selected cohort, the SAD most commonly reported in association with chronic HCV infection were Sjögren’s syndrome (nearly half the cases), Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus. M. Ramos-Casals. J. Rheum. April 15, 2009. (Also see: Sjogren's and RA). |
| Fibromyalgia (FM), Systemic Lupus Erythematosus (SLE), and Evaluation of SLE Activity. The prevalence of FM in SLE is minimally increased compared with its prevalence in patients with arthritis. F. Wolfe. J Rheumatol. November 1, 2008. (Also see: Fibromyalgia) |
| Pediatric Lupus |
| Systemic lupus erythematosus (SLE) presenting with pulmonary thromboembolism in a 15-year-old girl. The combination of a history of thrombocytopenia and the presence of antinuclear antibodies, even in the absence of any other diagnostic criteria, should always suggest considering SLE as a differential diagnosis, particularly when the course of a clinical manifestation is atypical. (SpringerLink) L. Dell’Era. Rheumatology International. April 8 2010. (Also see: Symptoms of Lupus) |
| Impact of lupus (SLE) on school attendance and performance. SLE and activities related to caring for the disease clearly impose a burden on children’s school attendance and performance. School-related activities can have a significant impact on HRQOL in children and adolescents with SLE. Moorthy LN. (PubMed) Lupus. 2010;19(5):620-7. |
| Acute epiglottitis as the initial presentation of pediatric Systemic Lupus Erythematosus (SLE). To the best of our knowledge, this article describes the first case of Haemophilus influenzae type f epiglottitis as the initial presentation of SLE in childhood. S. Charuvaniz. Pediatric Rheumatology. October 31 2009. |
| Influence of age at disease onset in the outcome of paediatric systemic lupus erythematosus (pSLE). The poorer outcome observed in younger children may be explained by a more severe disease expression, may be a higher infectious susceptibility, and a more aggressive therapy, particularly within the first 6 months of disease course. E. Descloux. Rheumatology Advance Access. May 4 2009. |
| Treatments for Lupus |
| Treatments for Lupus. ISN. |
| Lupus Research |
| Concentrated autologous bone marrow aspirate transplantation (CABMAT) treatment for corticosteroid-induced osteonecrosis of the femoral head (ONFH) in systemic lupus erythematosus (SLE). CABMAT using our centrifugation technique is an effective, safe and low-cost procedure of therapeutic osteogenesis for corticosteroid-induced ONFH in SLE. (SpringerLink) T. Yoshioka. International Orthopaedics. May 29 2010. |
| Relationship Between Flare and Health-related Quality of Life (HRQOF) in Patients with Systemic Lupus Erythematosus. The low level of patients’ HRQOL is mostly associated with the presence of musculoskeletal involvement. Journal of Rheumatology. Vol. 37 No. 3 568-573. January, 2010. |
| Vitamin D insufficiency in a large female SLE cohort. Sub-optimal vitamin D status is common in women with systemic lupus erythematosus and is related to season, cumulative glucocorticoid dose, and serum creatinine. (SageJournals) SMA Toloza. January 1 2010. |
| Comparative study on circulating endothelial progenitor cells (CPECs) in systemic lupus erythematosus (SLE) patients at active stage. Our data show that CEPC number in active SLE patients was not significantly different from healthy controls, but their functions were partly impaired, including proliferation, adhesion, migration, and tube formation. Bad cell status and increased susceptibility to inflammatory process of CEPCs in active SLE were also observed in our study. Xiao Li Deng. Rheumatology International. October 21, 2009. |
| Vitamin D deficiency in systemic lupus erythmatosus (SLE): prevalence, predictors and clinical consequences. Vitamin D insufficiency and deficiency are common in patients with SLE and are associated with sun avoidance. G. Ruiz-Irastorza. Rheumatology Advance Access. April 14, 2008. |
| Medical researchers predict 'flood of discoveries' soon. What allows Harley and researchers worldwide to come closer to targeting lupus' underpinnings is the Oklahoma Medical Research Foundation's Lupus Family Registry and Repository, a decade-long, $20 million collaboration with the National Institutes of Health. It contains genetic profiles and blood samples from thousands of lupus sufferers and their relatives. NewsOK.com. 09/14/07. |
| New Insights Into Autoimmunity And Depression. Some studies have described a possible link between Lupus's most severe psychiatric manifestation, psychosis, and a protein autoantibody associated with the central nervous system, anti-ribosomal P. ScienceDaily. 03/09/07. (Also see: Emotional Adjustment) |
| Support for Lupus |
| Lupus Foundation of America launches new national magazine The Lupus Foundation of America has a magazine dedicated to lupus, a life-threatening autoimmune disease affecting 1.5 million Americans. Lupus Foundation of America. |
| Personal Stories About Lupus |
| Lupus Personal Stories. These stories include suspected lupus and lupus misdiagnosis, as well as those with Overlap Syndrome. (Also see: Difficult Diagnosis and Overlap Syndrome) |
| Aileen: CREST Scleroderma Oh, the wonderful feeling to have a doctor sit there and tell you that you are not imagining things... |
| Amy B: Limited Scleroderma with CREST I am a full time pharmacist in a pediatric hospital. In February or March of this year, I began to be very intolerable of the cold... |
| Anna: Linear Scleroderma (Poland) I realised that it is not worthwhile to give up, even during the most difficult moments; it is necessary to fight and to believe that it will be better. If I had not believed I would not have been alive now... |
| (Italiano) Antea: Sindrome di Sjogren e il Lupus Eritematoso Sistemico Sono Angela dalla provincia di pesaro, ho 29 anni e da ieri ho scoperto di avere la Sindrome di Sjogren... |
| Many More Personal Stories about Lupus. ISN. |
| Lupus Media Stories |
| Media Stories about Lupus. ISN. |
Get our free Sclero e-Newsletter!
Player Registration for 5th Annual Scoring for Scleroderma Soccer Tournament in Bridgewater, Massachusetts.