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Antibodies in Lupus

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Antiphospholipid (aPL)
C Reactive Protein (CRP)
Scl-70 (topo-I) (ATA)


There are a wide variety of autoantibodies associated with lupus. Some of the antibodies are helpful in diagnosing the illness, while others are more useful in detecting disease activity or potential complications. (Also see: Autoimmune Diseases and Overview of Lupus)
Distinct antibody profile: a clue to primary antiphospholipid syndrome (PAPS) evolving into systemic lupus erythematosus (SLE)? The detection of a distinct subgroup of lupus-associated autoantibody in PAPS patients seems to be a hint to overt SLE disease, particularly in those patients with young age at diagnosis. PubMed, Clin Rheumatol, 2014 Jan 14. (Also see: Antiphospholipid Syndrome)
Autoantibodies and SLE-the threshold for disease. The current findings are summarized regarding the presence of SLE-associated antibodies in apparently healthy individuals, and provide opinions on what such discoveries might tell us about the roles of autoantibodies in the development of disease. PubMed, Nat Rev Rheumatol, 2013 Dec 3. (Also see: Autoantibodies)
Lots of autoantibodies equal systemic lupus erythematosus (SLE)? Autoantibodies may be found years before an autoimmune disease becomes clinically apparent and in patients with early SLE; no single antibody class or specificity is associated with progression to SLE. Arthritis Research & Therapy 2013, 15:102.

Antiphospholipid Antibodies (aPL)

The role of antiphospholipid autoantibodies (aPL) in the cognitive deficits of patients with systemic lupus erythematosus (SLE). Results support the relationship between aPL and cognitive symptoms in SLE. PubMed, Lupus, 02/18/2015.
Cigarette smoking, antiphospholipid antibodies (aPL) and vascular events (VE) in Systemic Lupus Erythematosus (SLE). Among ever regular smokers who were aPL positive, there was a strikingly high frequency of former VE and the underlying mechanisms and temporality between smoking, aPL and VE need further investigations. PubMed, Ann Rheum Dis, 2014 Apr 1. (Also see: Antiphospholid Syndrome)

C Reactive Protein (Anti-CRP)

Anti-CRP antibodies in systemic lupus erythematosus. Anti-CRP autoantibodies, which are found in 35 to 40% of SLE patients, increase the cardiovascular risk by interacting with the monomeric (degraded) form of CRP. PubMed, Joint Bone Spine.

NKG2A Antibodies

Anti-NKG2A autoantibodies in a patient with systemic lupus erythematosus (SLE). NKG2A autoantibodies are rare, but when they occur they may contribute to the pathogenesis by increasing the killing of cells and the release of autoantigens. PubMed, Rheumatology, 2013 Jul 3.

Scl-70 (topo-I)(ATA)

Anti-Scl-70 (topo-I) antibodies (ATA) in Systemic Lupus Erythematosus (SLE): Myth or reality? Given that SLE is approximately 100 times more prevalent than systemic sclerosis (SSc), the number of ATA positive SLE patients is 2-3 orders of magnitude greater than the prevalence of ATA in SSc. Autoimmun Rev, 2010 Jun 22.(Also see: Overview of Lupus)
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