Autoimmune
Diseases:
Systemic Lupus Erythematosus (SLE) |
| This page was written
by Shelley Ensz, and has
not yet been medically edited. See Disclaimer. |
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| Causes of Lupus |
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| B
Cells and T Cells |
| Two Proteins Have Unexpected Effects On Autoimmune Diseases Such As Lupus. Blocking the effect of individual immune system proteins that normally recognize viruses and bacteria produces surprisingly different effects on the severity of autoimmune diseases. Drugs that target these proteins could be important therapies for autoimmunity. Medical News Today. 09/30/06. (Also see: B cells, T cells and Autoimmunity) |
| B Cell Targeted Therapies in Autoimmune Diseases. Although these studies contain small cohorts of patients, they demonstrate that B cell-modulating therapies show promise in treatment of a variety of autoimmune diseases such a lupus, myositis, and vaculitis.J Rheumatol 2006 May;33 Suppl 77: 24-28. (Also see: Causes of Scleroderma: B Cells and T Cells, Dermatomyositis, and Vasculitis) |
| Coronin-1A Gene |
| New Genetic Mutation That Halts The Development Of Lupus Discovered. The lupus-suppressing action is the result of what is known as a nonsense mutation of the Coronin-1A gene (Coro1a) required for the development of the disease. ScienceDaily. 01/17/08. |
| Environmental
Exposures |
| Is lipstick associated with the development of systemic lupus erythematosus (SLE)? There was a trend of greater risk with earlier age of initiation of lipstick use and with increased frequency of use. Biologic effects of chemicals present in lipsticks absorbed across the buccal mucosa and confounding from unmeasured lifestyle factors could be the explanation of this association. (SpringerLink) Clinical Rheumatology. June 4, 2008. |
| An impaired clearance of dying cells can lead to the development
of chronic autoimmunity. An impaired clearance of dying
cells represents a central pathogenic process in the development
of chronic autoimmune diseases like in systemic lupus erythematosus
(SLE). PubMed. Z Rheumatol. 2005 Sep;64(6):370-376. |
| Cigarette
Smoking Increases Lupus Risk. Smoking cigarettes increases
risk of developing lupus —but quitting cuts that risk,
new research shows. The toxins can potentially interact
with DNA, causing genetic mutations and gene activation
leading to development of autoimmune diseases. WebMD
03/04/04. |
| Occupational
and environmental exposures as risk factors for systemic
lupus erythematosus. This paper describes epidemiologic
and experimental research pertaining to occupational and
environmental sources of exposure to respirable crystalline
silica, solvents and pesticides, and two "lifestyle" factors
(smoking and hair dye use). PubMed.
Curr Rheumatol Rep. 2004 Oct;6(5):367-74. (Also see: Causes
of Scleroderma: Environmental) |
| Genetics |
| New Batch of Lupus Genes Discovered. "It's an important moment in autoimmune disease research." U.S. News & World Report. 01/21/08. (Also see: Autoimmunity) |
| Genes
Add Up Risk Of Autoimmune Disease. Geneticists have identified a link
between the number of copies of a specific gene an individual has and their
susceptibility to autoimmune diseases like lupus that affect the whole body. Medical
News Today. 05/25/07. (Also see: Causes of Scleroderma: Genetics and Autoimmunity) |
| Gene
associatied with lupus identified. Researchers at the
University of Minnesota have identified, for the first
time, a gene variation associated with systemic lupus erythematosus
(SLE), a complex, inflammatory autoimmune disease that
affects multiple organs. innovationsreport.
University of Chicago Press Journals 08/19/04. |
| Birth
Order and Maternal Microchimerism in Pediatric SLE. More
than half of the patients with SLE were not firstborn which
is in support of the hypothesis of increased risk for SLE
(although this cohort only contained 1 SLE sib-pair). There
was a high percentage of firstborn patients with antiphospholipid
antibodies in the first cohort group and there is a chance
that their mothers may also have had antiphospholipid antibodies,
thus conferring risk for fetal loss. Christine
B. Bernal. ACR Conference Oct. 2003. (Also see: Fetal
Cells and Scleroderma and Antiphospholipid
Syndrome) |
| Triplets
with systemic lupus erythematosus. We present herein
the first case report of identical triplets who developed
systemic lupus erythematosus (SLE). Although genetically
identical, each sibling manifested different clinical signs
and symptoms. PubMed.
Arthritis Rheum. 2003 Nov;48(11):3176-80. |
| Infection |
| A human T-cell lymphotropic virus type-1 (HTLV-1) carrier complicated with various autoimmune diseases including primary biliary cirrhosis. A 47-year-old woman diagnosed as having overlap syndrome with scleroderma, systemic lupus erythematosus and possible polymyositis associated with primary biliary cirrhosis. (The tests) suggest the possibility of a relationship between HTLV-1 infection and various autoimmune disorders including primary biliary cirrhosis. PubMed. Hepatol Res. 2005 Feb 7. (Also see: Overlap Syndrome, Liver Involvement, and Polymyositis) |
| Sarcoidosis succumbs to antibiotics-implications for autoimmune disease. From time to time there have been reports of autoimmune disease succumbing to tetracycline antibiotics, but many have assumed this was due to coincidence, or to some ill-defined 'anti-inflammatory property' of the tetracyclines. But now the inflammation of sarcoidosis has succumbed to antibiotics in two independent studies. Finally, data showing that the behavior of this hormone is also aberrant in rheumatoid arthritis, systemic lupus erythematosus, and Parkinson's, raise the possibility that these diseases may also have a CWD bacterial pathogenesis. PubMed. Autoimmun Rev. 2004 Jun;3(4):295-300. (Also see: Rheumatoid Arthritis, Sarcoidosis and Causes of Scleroderma: Infection) |
| Medications |
| Why minocycline can cause systemic lupus - a hypothesis and suggestions for therapeutic interventions based on it. The tetracycline antibiotic minocycline is widely used in dermatology, but can sometimes cause systemic lupus erythematosus, a serious autoimmune disorder. PubMed. Med Hypotheses. 2004;63(1):31-4. (Also see: Minocycline) |
