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Multiple Sclerosis

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overview of Multiple Sclerosis
Symptoms of MS
Overlaps with MS
MS and Glandular Fever
MS and Scleroderma
Causes of MS
Treatments and Clinical Trials
MS Research
Personal Stories About MS
Support Organizations
MS Media Stories

Overview of Multiple Sclerosis (MS)

Multiple sclerosis is an autoimmune disease that affects the brain and spinal cord (central nervous system). PubMed, Health.

Symptoms of Multiple Sclerosis

The relationship between total and regional corpus callosum atrophy, cognitive impairment and fatigue in multiple sclerosis patients. Atrophy of the corpus collosum (CC) is associated with cognitive impairment and fatigue. Regional corpus callosum index results indicate that these associations are partially spatially segregated. PubMed, Mult Scler, 08/29/2013.
Possible Symptoms of Multiple Sclerosis. Symptoms may include weakness, numbness, pain, disturbances of speech or vision, parasthesias, ataxia, tremor, dizziness, bladder or bowel dysfunction, fatigue, cognitive problems and depression. WebMD.
Bone health and multiple sclerosis. Osteoporosis is a major cause of morbidity and mortality, and is more common in people with MS than the general population. Multiple Sclerosis Journal. November 2012 vol. 18 no. 11 1522-1528.

Overlaps with Multiple Sclerosis

Validation of a self-report comorbidity questionnaire for multiple sclerosis (MS). Self-report is a valid way to capture comorbidities affecting MS patients. Horton M. (PubMed) Neuroepidemiology. 2010 Aug;35(2):83-90.
Multiple Sclerosis Patients Should Have Thyroid Evaluation. Study results published in the European Journal of Neurology found antithyroid antibodies (antibodies against peroxidase and thyroglobulin) five times more prevalent in people with untreated multiple sclerosis (MS). Mary Shomon, About.com.

Multiple Sclerosis and Glandular Fever

Evidence accumulates for the role of Epstein-Barr virus in Multiple Sclerosis (MS). In the more thorough studies where two independent methods had been used, all adults with MS showed evidence of EBV infection. These results strongly support a role for EBV in the development of MS. MS Research Australia. 07/09/12. (Also see: Multiple Sclerosis)

Multiple Sclerosis and Scleroderma

Multiple sclerosis (MS) sometimes occurs along with other autoimmune diseases, but seems to be rare in association with systemic scleroderma. Very few cases have been identified in medical journals.
Lisa W: Diffuse Scleroderma, CREST and Multiple Sclerosis I was recently diagnosed with multiple sclerosis (MS). That also took over a year to diagnose. My doctors tell me that I am one out of millions with this case of bad luck...

Causes

Gender differences in multiple sclerosis (MS): induction of estrogen signaling in male and progesterone signaling in female lesions. The different gender–specific responses in steroid synthesis and signaling in the brains of multiple sclerosis (MS) patients may represent contributing factors to gender differences in the prevalence and course of MS. PubMed, J Neuropathol Exp Neurol. 2014 Feb;73(2):123-35.
What Does Your Birthday Have to Do With Immune Disorders? The month in which babies are born can affect how their immune systems develop, and even how vulnerable they are to autoimmune diseases. Time Healthland. 04/11/2013. (Also see: Vitamin D Deficiency)
Multiple Sclerosis may not be autoimmune disease. Dr. Angelique suggests instead that MS is caused by faulty lipid metabolism -- in many ways more similar to coronary atherosclerosis -- hardening of the arteries -- than to other autoimmune diseases. UPI. 01/01/12.

Treatments and Clinical Trials

How a daily statin tablet could slow march of Multiple Sclerosis (MS). Statins have been shown to have anti-inflammatory and neuroprotective effects on the nervous system and previous research using simvastatin in people with early-stage MS found reductions in brain lesions, suggesting the statin was affecting the disease process. Mail Online, 03/19/2014. (Also see: Statins)
T cell repertoire (TCR) following autologous stem cell transplantation for multiple sclerosis. TCR characterization during immunomodulatory treatment is both feasible and informative, and may enable monitoring of pathogenic or protective T cell clones following HSCT and cellular therapies. PubMed, J Clin Invest. 2014 Feb 17. (Also see: Stem Cell Transplantation)
New approach could treat MS, other autoimmune diseases. Researchers trying to find a way to treat multiple sclerosis think they've come up with an approach that could not only help patients with MS, but those with a range of so-called autoimmune diseases, from type-1 diabetes to psoriasis, and perhaps even food allergies. NBC News, 11/18/12.
Scientists claim artificial sunshine may be key to treating Multiple Sclerosis (MS). The study shows that UV-B light, which mimics sunshine, can have a striking effect on the immune system of patients. Scotland News. 07/17/12. (Also see: Causes of Scleroderma: Vitamin D Deficiency)

Research

Managing treatment fatigue in patients with multiple sclerosis (MS) on long-term therapy: the role of multiple sclerosis nurses. Patients with MS on long-term therapy may suffer from treatment fatigue and poor adherence. MS nurses are ideally situated to help patients cope with any factors that may limit adherence. PubMed, Patient Prefer Adherence, 2014 Aug 19;8:1093-9. (Also see: Fatigue)
High vitamin D may prevent multiple sclerosis. A study published recently in Neurology suggests that exposure to the sun or taking vitamin D supplements may help reduce risk of multiple sclerosis (MS). FoodConsumer. 11/01/12.

Personal Stories About Multiple Sclerosis or Difficult Diagnosis

Autoimmune diseases such as multiple sclerosis, lupus and scleroderma can be very difficult to properly diagnose, particularly in the early stages of illness. Many of these stories regard onset of scleroderma during which time MS was considered as a possible diagnosis. (Also see: Difficult Diagnosis)
Boo: CREST Scleroderma Finally in 1994, it was labeled as CREST syndrome, which is a form of systemic scleroderma...
Beverly: CREST Scleroderma I was overtired and needed naps in the afternoon, pain was slowly getting the better of me and I finally went to the doctor...
Carla: CREST Syndrome and Fibromyalgia When I read some of these stories, they scare the devil out of me. Is this really that bad?...
Cindy Fuchs-Morrissey: Mother of a Progressive Systemic Sclerosis Child Hilary has an aggressive form of scleroderma with swallowing problems, bowel problems, fatigue, acral bone dysplasia of the hands and feet...
Debbie: CREST Here's a copy of a letter I sent to my rheumatologist....
Kathi: Scleroderma/Lupus I am forty-three years old and have not been feeling well for ten years...
Krisha S: Multiple Autoimmune Condition I have multiple sclerosis (MS), fibromyalgia, and Stiff Person Syndrome...
Lisa W: Diffuse Scleroderma, CREST and Multiple Sclerosis I was recently diagnosed with multiple sclerosis (MS). That also took over a year to diagnose. My doctors tell me that I am one out of millions with this case of bad luck...
McKenzie: Scleroderma with CREST I felt numbness crept down both my legs. I said, "I can't feel my legs!" and sat down on the floor...
Nan: Mixed Connective Tissue Disease and Fibromyalgia Finally after several years of struggle, one wonderful doctor at OSU got gutsy and gave me the MCTD diagnosis...

Support

(U.S.) National Multiple Sclerosis Society The mission of the National Multiple Sclerosis Society is to end the devastating effects of MS. National Multiple Sclerosis Society.

Media Stories

Stress Management May Prevent Multiple Sclerosis (MS) Brain Lesions. Patients with multiple sclerosis who attended stress management therapy sessions for six months had fewer new brain lesions from disease flare-ups and slower disease progression during their treatment. WebMD. 07/11/12.
 
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