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Rheumatoid Arthritis in Overlap

Rheumatoid Arthritis in overlap is when RA is found with other autoimmune diseases or chronic illness. RA is often found in overlap with other connective tissue diseases such as scleroderma, lupus, and polymyositis/dermatomyositis. It can also be found with other diseases such as thyroiditis, fibromyalgia, and sjogren's. (Also see: Overlap Syndromes/MCTD/UCTD)
Systemic Autoimmune Diseases (SAD) in Patients with Hepatitis C Virus (HCV) Infection: Characterization of 1020 Cases (The HISPAMEC Registry). In the selected cohort, the SAD most commonly reported in association with chronic HCV infection were Sjögren's syndrome (nearly half the cases), Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus. M. Ramos-Casals. J. Rheum. April 15, 2009. (Also see: Sjogren's and Lupus).
Familial associations of rheumatoid arthritis (RA) with autoimmune diseases and related conditions. This is the first study to compare the familial risks of RA in relation to a large number of autoimmune diseases and related conditions using data from a single population. The high discordant familial risks in this population suggest that there is extensive genetic sharing between RA and the associated diseases. Kari Hemminki. Arthritis Rheum. 2009 Mar;60(3):661-8.
Polymyalgia rheumatica (PMR) can be distinguished from late onset rheumatoid arthritis (RA) at baseline: results of a 5-yr prospective study. Our longitudinal follow-up data were consistent with RF negative late onset RA being a separate disease entity to PMR despite some phenotypic and immunogenetic similarities at disease onset. C. T. Pease. Rheumatology Advance Access. November 2, 2008. (Also see: Shared Autoimmunity)
Autoimmune Thyroiditis and Rheumatoid Arthritis RA) : Is There Really an Association? There was no correlation between thyroid disease and rheumatoid factor, antinuclear antibodies, disease modifying drugs use, corticosteroid use, or RA disease activity. In conclusion, no association could be demonstrated between thyroid disease and RA. F.T. Goncalvez, MD. The Endocrinologist. January/February 2009. (Also see: Thyroid Disease)
Rheumatoid Arthritis (RA) and Fibromyalgia (FM): A Frequent Unrelated Association Complicating Disease Management. The association between RA and FM does not appear to be a marker of worse prognosis, but rather a fortuitous association between the 2 diseases and one that may afford these patients some protection against joint destruction. F. Choury. J Rheumatol. January 2009. (Also see: Fibromyalgia)
Autoimmune Thyroiditis (AIT) and Rheumatoid Arthritis (RA): Is There Really an Association? Previous studies suggest an association between AIT, an organ-specific autoimmune disease, and RA, a systemic autoimmune disorder. Our study suggests that, at least in some populations, this association does not occur, or it is not strong enough-from the epidemiologic point of view-to justify the routine thyroid antibodies and thyrotropin tests in all RA patients. F.T. Goncalves. Endocrinologist. January/February 2009. (Also see: Thyroid Disease)
Rheumatoid Arthritis (RA) and Fibromyalgia (FM): A Frequent Unrelated Association Complicating Disease Management. The association between RA and FM does not appear to be a marker of worse prognosis, but rather a fortuitous association between the 2 diseases and one that may afford these patients some protection against joint destruction. F. Coury. JRheumatol Dec 15 2008. (Also see: Fibromyalgia)
 
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