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Cardiac (Heart) Involvement in Systemic Sclerosis (Scleroderma)

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overview and Video
Correlation with Other Diseases
Systemic Scleroderma
Personal Stories

Overview and Video

Scleroderma Heart Involvement
Presented by Amanda Thorpe

The systemic forms of scleroderma can cause cardiac (heart) problems. One of the earliest symptoms reported by diffuse systemic scleroderma patients is heart irregularities. Systemic scleroderma can cause arrhythmias, pericardial effusion, and heart failure.

Formation of scar tissue in the heart and lungs has recently been recognized as a general pattern probably contributing to overall fatigue. It is very important for people with diffuse scleroderma to see a listed scleroderma expert and to report any heart-related symptoms if or when they arise. (Also see: What is Scleroderma? and Types of Scleroderma, and Scleroderma Experts)

Even with breaks for exercise, lengthy sitting linked to heart disease The latest research marks the first to show that punctuating sedentary behavior with exercise does not undo the harm of sitting for lengthy periods. Los Angeles Times, 03/05/2015.
Do Heart Patients Fare Better When Doc Is Away? High-risk patients with heart failure and cardiac arrest had lower 30-day mortality rates when admitted to teaching hospitals during dates of two national cardiology meetings. MedPage Today, 12/22/2014.
How Low Should We Go? (When It Comes To Blood Pressure). A new study suggests getting blood pressure as low as possible may not be critical for people with hypertension. Time Healthland, 06/17/2014.
Diet, exercise key for improving heart health. The American Heart Association wants to improve the heart health of all Americans by 20 percent by 2020. Chicago Tribune, 10/18/2013.
Working Too Hard? Physically Demanding Jobs Tied to Higher Risk of Heart Disease. While physical activity can lower the risk of heart disease, two studies suggest that jobs involving hard manual labor may harm, rather than help the heart. Time Healthland, 04/19/2013.

Cardiac (Heart) Symptoms

Cardiac (Heart) Symptoms. Common symptoms of heart failure include breathing difficulties, fatigue and exercise intolerance, and coughing. ISN.
Heart Symptoms in Women
Chest Pain
Common Symptoms of Heart Failure
Fainting (Syncope)

Correlation Between Cardiac and Other Diseases

Screening men with erectile dysfunction (ED) for heart disease could save money, lives. If every man with erectile dysfunction were screened for heart disease, more than a million events like heart attack or stroke could be avoided, according to a new estimate. Reuters Health, 03/11/2015. (Also see: Erectile Dysfunction)
Myopathies related to systemic sclerosis: a case-control study of associated clinical and immunological features. Heart monitoring of SSc patients with myopathy should be undertaken regularly because of the association of myocardial and skeletal myopathies in such patients. PubMed, Scand J Rheumatol, [2010]. (Also see: Myopathies)
Antiphospholipid Syndrome (APS) and Heart Disease. ISN.

Systemic Scleroderma Heart Involvement

Systemic Scleroderma Cardiac (Heart) Involvement. The systemic forms of scleroderma can cause cardiac (heart) problems. One of the earliest symptoms reported by diffuse systemic scleroderma patients is heart irregularities. ISN.
Aortic Stiffness
Asymptomatic Pericardial
Cardiac Remodeling
Carotid Artery Disease
Left Ventricular Diastolic Dys
Lipoprotein[a], Thrombotic
Mitral/Tricuspid Valve
Myocardial Ischemia
Right Ventricular Dys
Stroke and TIA
Vascular Disease and Systemic Scleroderma. The vascular system is our circulatory system. It consists of all the vessels that carry blood and lymph through the body, to and from organs. Vessels include arteries, veins, and capillaries. Any condition that affects the vascular system, all of in part, is considered a vascular disease. ISN.
Vascular in Scleroderma
Types in Scleroderma
In Other CTDs
Personal Stories
Related Information

Complications with Systemic Scleroderma Heart Involvement

Complications with Systemic Scleroderma Cardiac (Heart) Involvement include atrioventricular heart block, cardiogenic shock, myocardial infarction, and skeletal myopathy. ISN.
Aortic Valve Insufficiency
Asymptomatic, Multiple Associations
Atrioventricular Heart Block
Cardiogenic Shock
Cardiac Tamponade
Diastolic Dysfunction
Macrovascular Disease
Myocardial Infarction
Skeletal Myopathy


Diagnosis of Systemic Scleroderma Cardiac (Heart) Involvement. It is common for patients with systemic scleroderma to develop heart involvement even without any overt cardiac symptoms, so mandatory assessment of systemic scleroderma heart involvement requires a thorough baseline screening and follow-up monitoring. ISN.
CT Scans
--ECHO (General)
--Tissue Doppler
Heart Rate
Holter Monitoring


Treatments for Systemic Scleroderma Cardiac (Heart) Involvement include Bosentan, and calcium channel blockers such as nicardipine (Cardene) and nifedipine (Adalat, Procardia). ISN.
Beta Blockers
Bosentan, Tracleer
Combination Therapy
Calcium Channel Blockers
Nicardipine, Nifedipine
Coronary Artery Bypass
Dietary Approaches
Pericarditis Treatments


Research about Systemic Scleroderma Heart Involvement. Topics include antibodies, autoimmunity, case studies, and causes of scleroderma heart involvement. ISN.
Autoimmunity and Heart Disease
Causes of Heart Disease

Personal Stories: Cardiac (Heart) Involvement

Patient and Caregiver Stories: Cardiac (Heart) Involvement. ISN.
Anastasia: Surviving Granddaughter of a Diffuse Scleroderma Patient Traveling to a different hospital finally we heard scleroderma...
Angela S: Overlap Syndrome I am twenty-five years old and I was diagnosed with polymyositis and scleroderma, rheumatoid arthritis, mitral valve prolapse, a heart murmur, and pericarditis...
Angiola: Progressive Systemic Scleroderma (Italy) I would very much like to find other people that find themselves in a similar situation...
Read more stories...
Go to Complications

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