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Bowel Dysfunction in Systemic Scleroderma

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Causes of Bowel Dysfunction
Constipation: Treatments
Diarrhea: Treatments
Bowel Incontinence
Bowel Management
Bowel Surgery
Habba Syndrome
Intestinal Pseudo-Obstruction
Intestinal Bacterial Overgrowth
Inflammatory Bowel Disease (IBD)
—Collagenous Colitis
—Crohn's Disease
—Ulcerative Colitis
Irritable Bowel Syndrome (IBS)


Abstract paintingSystemic sclerosis (scleroderma) can cause constipation, diarrhea, collagenous colitis, irritable bowel syndrome (IBS), malabsorption, diminished peristalsis, and bowel incontinence. It can also overlap with Crohn's disease and ulcerative colitis.

Typical in the initial stages of scleroderma is chronic constipation, sometimes alternating with diarrhea. Late stage scleroderma bowel involvement is often marked by diarrhea, malabsorption, and bowel incontinence. (Also see: Scleroderma Gastrointestinal Involvement, What is Scleroderma?, Types of Scleroderma, and Systemic Sclerosis)

Scleroderma small bowel involvement. (2 images) Hidebound or stack of coins appearance: narrow separation between the valvulae conniventes which are of normal thickness despite dilatation of the bowel lumen. Dr. Andrew Dixon. Radiopaedia.org. 05/03/10.
Anorectal Motility and Sensation Abnormalities and Its Correlation with Anorectal Symptoms in Patients with Systemic Sclerosis: A Preliminary Study. Scleroderma patients have impaired anorectal motor and sensory functions, and the abnormality score of these anorectal functions is correlated with the total anorectal symptoms score. These scoring systems may assist clinicians in predicting dysmotility based on patient symptoms. Hanaa S. Sallam. (Hindawi) ISRN Gastroenterology, Volume 2011, Article ID 402583.

Causes of Bowel Dysfunction in Systemic Scleroderma

Peristalsis: Scleroderma can cause diminished peristalsis. Peristalsis is the wavelike motion in the muscles of the GI tract.
Abdominal distention is a common condition, which usually results from over-eating, rather than from a serious illness. It can also be caused by lactose intolerance, air swallowing, irritable bowel syndrome, and partial bowel obstruction. Medline Plus.

Constipation: Treatments (1)

Type of Product Generic Name Brand Names
Bulking Agents Polycarbophil FiberCon ® or Fiberall ®
Psyllium Metamucil ®
Softening Agents Docusate Colace ®
Others Lactulose
Cephulac ®, Cholac ®
Dulcolax ®

Diarrhea: Treatments (Small Bowel Dysfunction)(1)

Type of Product Generic Name Brand Names
Broad Spectrum Antibiotics Tetracycline, Ampicillan, Vancomycin
Metronidazole Flagyl ®
Clarithromycin Biaxin ®
Azithromycin Zithromax ®
Investigational for SD Octreotide Acetate Sandostatin ®

Bowel Incontinence

Faecal incontinence in patients with systemic sclerosis: is an impaired internal anal sphincter the only cause? The main cause of faecal incontinence in SSc is poor function of the internal anal sphincter smooth muscle. Fynne L. (PubMed) Scand J Rheumatol, 2011 Jul 4.
Internal anal sphincter (IAS) atrophy in patients with systemic sclerosis (SSc). Patients with SSc (both symptomatic and asymptomatic) have thin and atrophic internal anal spincters (IAS), suggesting that IAS atrophy develops even in asymptomatic patients and this may be amenable to treatment with sacral neuromodulation. Nora M. Thoua, Rheumatology, April 18, 2011.

Bowel Management

Eating 1 to 2 tablespoons a day of live culture acidophilus yogurt may be helpful for combatting bowel involvement with systemic scleroderma, especially small bowel bacterial overgrowth. It may also be particularly helpful when taking antibiotics. It has the additional benefit of being nutritious and easy to swallow. Only a very few brands/types of yogurt (especially in the U.S.) have live cultures, so study product labels carefully.
Elimination Problems Use this chart when you or a family member has pain, itching or blood with a bowel movement. familydoctor.org

Bowel Surgery: Ileostomy, Colostomy, and Ileoanal Reservoir

Ileostomy, Colostomy, and Ileoanal Reservoir Surgery. Sometimes treatment for Crohn's disease, ulcerative colitis, and familial adenomatous polyposis involves removing all or part of the intestines. NDDIC.
Sandy J: CREST Scleroderma I have had an ileostomy for two years and a feeding peg for just over one year, and would appreciate comments from any person who also has one or both of these problems...

Habba Syndrome

Habba Syndrome Symptoms, Diagnosis and Treatment. This is chronic diarrhea that predominately occurs after meals, for at least three months. Diarrhea is often urgent, explosive, and may result in incontinence. About.com.

Intestinal Pseudo-Obstruction

Intestinal Pseudo-Obstruction Intestinal pseudo-obstruction (false blockage) is a condition that causes symptoms like those of a bowel obstruction (blockage). Symptoms include cramps, stomach pain, nausea, vomiting, bloating, fewer bowel movements than usual, and loose stools. Diseases that affect muscles and nerves, such as lupus erythematosus, scleroderma, or Parkinson's disease, can cause symptoms. NIDDK
Mortality, Recurrence, and Hospital Course of Patients with Systemic Sclerosis (SSc)-related Acute Intestinal Pseudo-obstruction. Acute intestinal pseudo-obstruction is a rare gastrointestinal manifestation of SSc with few data existing as to its demographics, clinical course, outcomes, and mortality. PubMed, J Rheumatol, 2014 Aug 15.
A new method for evaluation of intestinal muscle contraction properties: studies in normal subjects and in patients with systemic sclerosis. Systemic sclerosis patients had increased stiffness and impaired muscle dynamics of the duodenum. Decreased muscle function and increased wall stiffness may explain the GI symptoms reported in this patient group. PubMed, Neurogastroenterol Motil. (Also see: Gastrointestinal Involvement

Intestinal Bacterial Overgrowth

Scleroderma patients suffer from small bowel bacterial overgrowth. More than a third of patients with systemic sclerosis and intestinal symptoms have an increase in gastrointestinal tract bacteria, an alteration in the type of gut microbes present, or both. Rheumatology News, 07/02/2013.

Inflammatory Bowel Disease (IBD)

Inflammatory Bowel Disease (IBD) should not be confused with Irritable Bowel Syndrome (IBS) which is less severe. In particular, collagenous colitis should be suspected in systemic scleroderma patients who develop watery diarrhea. ISN.
Correlation with Other Diseases
Collagenous Colitis
Crohn's Disease
Ulcerative Colitis
Support for IBD

Irritable Bowel Syndrome (IBS)

Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and interstitial cystitis. Sympathetic dysfunction could be the common underlying pathogenesis that brings on these overlapping clinical features. PubMed, J Clin Rheumatol, 2014 Apr;20(3):146-50. (Also see: Fibromyalgia, Chronic Fatigue Syndrome and Interstitial Cystitis)
Atrial fibrillation (AF) ablation in patients with gastroesophageal reflux disease (GERD) or irritable bowel syndrome (IBS): the heart to gut connection! 60% of AF patients with GERD and/or IBS triggered AF and a positive vagal response during radiofrequency catheter ablation (RFA), compared to only 13% of matched controls. PubMed, J Interv Card Electrophysiol, 2013 Jun 6. (Also see:GERD and Scleroderma Heart Involvement)
Irritable Bowel Syndrome. Up to one in five American adults has irritable bowel syndrome (IBS). For most people, signs and symptoms of IBS are mild. In many cases, you can control irritable bowel syndrome by managing your diet, lifestyle and stress. MayoClinic.
Inflammatory Bowel Diseases (IBD) vs. Irritable Bowel Syndrome (IBS). Oftentimes, variations of IBD can be mistaken for IBS, because both have a tendency to display similar symptoms in the same demographic of young adults. So how should a gastroenterologist decipher what's what? Lisa Cleary. Washington Health. 01/19/2011. (Also see: IBD)


Scleroderma can cause malabsorption, which is difficulty in the digestion or absorption of nutrients from food substances.
"Malabsorption caused by medical problems may be chronic and last for the remainder of a person's life. Some forms of malabsorption can be treated and corrected over time." University of Chicago
Home Parenteral Nutrition Program (TPN). TPN can be used at home by people whose digestive system can't absorb nutrition. Intravenous feeding may be temporary or lifelong. With time and experience, people using TPN can have improved quality of life. Mayo Clinic.


Systemic scleroderma can cause diminished peristalsis. Peristalsis is the wavelike motion in the muscles of the gastrointestinal tract.


Scleroderma Gastrointestinal Involvement. Almost every patient with scleroderma has symptoms or signs of gastrointestinal disease. Bloating, abdominal distention, diarrhea, bacterial overgrowth, weight loss, and constipation are common. Recurrent bouts of pseudo-obstruction are one of the most serious bowel problems in scleroderma. Medical Books Online.
Go to Dysmotility Syndrome in Scleroderma

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