| LUNG (PULMONARY): MAIN MENU |
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| Pulmonary Fibrosis |
| This page was written by Shelley Ensz, and has not yet been medically edited. See Disclaimer. |
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| Correlation between Pulmonary Fibrosis and other Diseases / Complications |
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| Correlation of Esophageal and Lung Involvement |
| Characteristics of Patients with Early Systemic Sclerosis and Severe Gastrointestinal Tract Involvement. Our findings strongly suggest the existence of a subgroup of SSc patients with severe GIT involvement in the early stage. Among the Japanese individuals, these patients never developed severe ILD, even though they were classified as having diffuse cutaneous SSc. J Rheumatol 2007;34:2050-5. (Also see: GI Involvement ) |
| Clinical features of scleroderma patients with contracture of phalanges (CP). Our study suggested that the presence of CP may be a marker of oesophageal involvement, pulmonary fibrosis and heart involvement. PubMed Clin Rheumatol. 2007 Aug;26(8):1275-7. (Also see: Joint Contractures, Esophageal Involvement,and Cardiac Involvement ) |
| Clinical features of scleroderma patients with contracture of phalanges (CP). The study suggested that the presence of CP may be a marker of oesophageal involvement, pulmonary fibrosis and heart involvement. PubMed. Clin Rheumatol. 2006 Dec 15. (Also see: Muscle and Joint Involvement, Esophageal Involvement and Cardiac Involvement ) |
| Esophageal Involvement is Correlated with Interstitial Lung Involvement (ILD) in Systemic Sclerosis (SSc) Patients. In our study, 100% of 25 unselected SSc patients showed some degree of GE disease by manometry. A significant correlation was shown between manometric parameters and the reduction of total lung capacity and DLCO. There may be simultaneous involvement in the natural course of the disease or esophageal involvement may favour aspiration phenomena and promote progression of ILD. E. Vesprini. FRI0104 EULAR 2005. (Also see: What is Scleroderma?, Esophageal Involvement, and Aspiration Pneumonia) |
| Prevalence of gastroesophageal reflux in end-stage lung disease candidates for lung transplant. Gastroesophageal reflux is highly prevalent in end-stage lung disease patients who are candidates for lung transplantation. Further investigation is needed to study the prevalence of gastroesophageal reflux after lung transplantation and its contribution to chronic allograft dysfunction. PubMed. Ann Thorac Surg. 2005 Oct;80(4):1254-60. (Also see: GERD) |
| Correlation of Pulmonary Fibrosis and Pulmonary Hypertension |
| Pulmonary Arterial Hypertension (PAH) and Severe Pulmonary Fibrosis in Systemic Sclerosis Patients with a Nucleolar Antibody. Scleroderma-specific autoantibodies and the FVC%/DLCO% ratio are helpful in determining whether a patient has PAH alone, PAH along with pulmonary fibrosis, or secondary PAH from chronic hypoxia with severe pulmonary fibrosis. J Rheumatol 2007;34:2230-5. (Also see: Pulmonoary Hypertension and Antibodies ) |
| High-Resolution Chest CT Findings Do Not Predict the Presence of Pulmonary Hypertension in Advanced Idiopathic Pulmonary Fibrosis. Chest CT-determined fibrosis score, ground-glass opacity score, honeycombing score, total profusion score, diameter of the main pulmonary artery, and the ratio of the pulmonary artery to aorta diameter did not differ between those with and without PH. There was no significant correlation between mean pulmonary artery pressure and any of the chest CT-determined measures. Chest. 2007; 132:773-779. (Also see: Pulmonary Hypertension ) |
| Pulmonary Hypertension (PH) in Patients With Interstitial Lung Diseases. PH in patients with interstitial lung diseases (ILDs) is not well recognized and can occur in the absence of advanced pulmonary dysfunction or hypoxemia. The ILDs most commonly associated with PH include connective tissue disease-related ILD, sarcoidosis, idiopathic pulmonary fibrosis, and pulmonary Langerhans cell histiocytosis.Red Orbit. 04/13/07. (Also see: Pulmonary Hypertension) |
| Prevalence and Characteristics of Moderate to Severe Pulmonary Hypertension in Systemic Sclerosis with and without Interstitial Lung Disease. Prevalence of moderate to severe PH was similar in SSc patients with and those without ILD. In patients with ILD, a lower PaO2 was the unique independent indicator associated with PH. In some patients with severe ILD, PH was out of proportion to the degree of fibrosis. J Rheumatol 2007May;34:1005-11. (Also see: Pulmonary Hypertension ) |
| Asymptomatic Pericardial Disease in Scleroderma-Associated Progressive Interstitial lung disease (ILD) and its Relationship to Pulmonary Hypertension.Asymptomatic pericardial disease is common in patients with SSc-associated progressive ILD, and its presence is associated with a high risk of echocardiographically defined pulmonary hypertension. Aryeh Fischer. 372/372. ACR 2005. (Also see: Cardiac Involvement and Pulmonary Hypertension) |
| Scleroderma Patients with Combined Pulmonary Hypertension and Interstitial Lung Disease. Patients with combined scleroderma lung disease features are more likely to have diffuse disease, represent older patients, and have a prognosis similar to individuals with isolated pulmonary hypertension, and may represent a distinct subpopulation of scleroderma. J Rheumatol. Volume 30: No. 11 November 2003;30:2398-405 (Also see: Pulmonary Involvement and Pulmonary Hypertension). |
| Correlation of Pulmonary Fibrosis and Heart Complications |
| Relationship Between Lung and Heart Involvement and Cardiopulmonary Functional Status in Patients with Systemic Sclerosis (SSc). According to our results, presence of tricuspid pressure gradient and high right ventricle systolic pressure were the most important factors that predict worsening of cardiopulmonary functional status in patients with SSc. M. B. Zlatanovic. SAT0264 EULAR 2006. (Also see: Cardiac Involvement ) |
| Cardiopulmonary Manifestations in Systemic Sclerosis (SSc) - Correlation with Disease Duration and the Extent of Skin Involvement. Interstitial pulmonary fibrosis in patients with SSc causes restrictive lung disease and progresses to severe lung damage and immunoinflammatory heart damage leading to ventricular diastolic dysfunction. B. N. Stamenkovic. AB0291 EULAR 2006. (Also see: Cardiac Involvement and Pulmonary Hypertension) |
| Asymptomatic Pericardial Disease in Scleroderma-Associated Progressive Interstitial lung disease (ILD) and its Relationship to Pulmonary Hypertension. Asymptomatic pericardial disease is common in patients with SSc-associated progressive ILD, and its presence is associated with a high risk of echocardiographically defined pulmonary hypertension. Aryeh Fischer. 372/372. ACR 2005. (Also see: Cardiac Involvement, and Pulmonary Hypertension) |
| Strong Association Found Between Fibrotic Lung Disorders And Coronary Artery Disease. Doctor's Guide. 03/10/04. Archives of Internal Medicine 2004;164:551-556. (Also see: Cardiac Involvement) |
| Correlation of Pulmonary Fibrosis and Connective Tissue Disease |
| Interstitial lung disease (ILD) in polymyositis and dermatomyositis (PM/DM): Longitudinal evaluation by pulmonary function and radiology. ILD associated with PM/DM is in most cases mild, chronic, and has a nonprogressive course during immunosuppressive treatment. Myositis patients with ILD need careful evaluation of clinical features as well as Pulmonary function test and radiologic features during followup. (Wiley Interscience) Arthritis Care & Research 25 April 2008 (Also see: DM/PM ). |
| Collagen vascular diseases and lung: Characterization of the outpatients with interstitial lung disease. The interstitial lung diseases associated with collagen vascular disease represent an important group of patients. The evolution is usually better than the one of the idiopathic forms. PubMed. Rev Port Pneumol. 2005 Nov;11(6 Suppl 1):26-7. |
| Comparison of disease progression and mortality of connective tissue disease-related interstitial lung disease (CTD-ILD) and idiopathic interstitial pneumonia (IIP). Contrary to expectation, CTD-ILD compared with IIP appears to be associated with a worse prognosis when adjusted for age. A higher fibrotic score is suggestive of decreased survival. PubMed. Arthritis Rheum. 2005 Aug 15;53(4):549-57. |
| Interstitial lung disease in connective tissue disorders. The prognosis of connective tissue associated ILD is better than that of idiopathic ILD. The treatment requires corticosteroids and/or immunosuppressants, depending on the nature of the associated connective tissue disease and ILD progression. PubMed. Rev Pneumol Clin. 2005 Jun;61(3):211-9. |
| Differences in Clinical Features and Prognosis of Interstitial Lung Diseases (ILD) Between Polymyositis (PM) and Dermatomyositis (DM). DM-ILD is more refractory to corticosteroid therapy, resulting in poorer prognosis compared with PM-ILD. These data indicate that intensive therapy, including cyclosporine, should be considered for DM-ILD. J Rheumatol. NO. 1 January 2005;32:58-64. (Also see: Polymyositis, Dermatomyositis) |
| Fibrotic diseases. Scleroderma is a chronic connective tissue disease, expressed clinically by systemic sclerosis and diffuse fibrosis of the skin and viscera. This is a progressive degenerative disorder of the blood vessels, skin, lungs, kidneys, heart and GI tract and for this reason this disease plays a major role in fibrosis research. PubMed. Harefuah 2002 Nov;141(11):973-8, 1009. (Also see: Skin Fibrosis) |
| Correlation of Pulmonary Fibrosis and Cancer |
| Associations of breast cancer development in patients with systemic sclerosis: an exploratory study. An older age at diagnosis of systemic sclerosis, a lack of ANA positivity, and the presence of pulmonary fibrosis were more commonly seen in patients with systemic sclerosis who have a diagnosis of breast cancer. PubMed. Clin Rheumatol. 2007 Feb 2. (Also see: Scleroderma and Cancer ) |
| Does interstitial lung disease predispose to lung cancer? Idiopathic pulmonary fibrosis, systemic sclerosis, and certain pneumoconioses are associated with an independent increased risk of lung cancer; however, a unifying pathogenetic mechanism to explain the causality of this association has not been described. PubMed. Curr Opin Pulm Med. 2005 Sep;11(5):431-7. (Also see: Scleroderma and Cancer) |
| Cancer and interstitial lung disease. Interstitial lung diseases for which the available evidence suggests an increased risk of lung cancer include idiopathic pulmonary fibrosis, systemic sclerosis, and certain forms of pneumoconioses. PubMed. Curr Opin Pulm Med. 2004 Sep;10(5):425-434. (Also see: Cancer and Scleroderma) |
| Correlation of Pulmonary Fibrosis and Thyroid Disease |
| Serum Endostatin Level in Patients with Systemic Sclerosis: Relationship to Thyroid Function, Skin Score and Pulmonary Fibrosis. Hypothyroidism should be considered as a endostatin-modulating factor in evaluation of fibrotic activity in the SSc patients. The role of endostatin in control of angiogenesis in SSc patients remains unknown. E. J. Kucharz. FRI0333 EULAR 2004. (Also see: Thyroid Disease) |
| Patient Stories |
| Brenda M: Primary Biliary Cirrhosis (PBC), Fibromyalgia, Pulmonary Fibrosis, and Sjogren's Syndrome In 1965, when I was twenty-six, I went to work for a firm of electro-platers, which was mainly aircraft work... |
| Debbie G: CREST, Lupus, Interstitial Lung Disease and Pulmonary Hypertension It has been a very long and bumpy road at times but somehow through all the hospital visits and other illnesses I have managed to stay ahead of the game by a step or two... |
| Don Alfera: CREST, Pulmonary Fibrosis and Sjögren's I entitled this "My Time So Far" since this has been a journey unlike any that I could have ever tried to imagine in my life... |
| Tony B: Systemic Scleroderma with Pulmonary Fibrosis, Pulmonary Hypertension and Raynaud's It has taken me some time to come to terms with this disease... |
| Judy Tarro: Diffuse Scleroderma, Sjogren's, Pulmonary Fibrosis and Pulmonary Hypertension The best we can figure, I was diagnosed with diffuse scleroderma in 1956. I am now webmaster of SD World... |
