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Sudden Hearing Losses Prompt Label Change for PDE5 inhibitors. The FDA said it found 29 reports of sudden hearing loss, sometimes temporary, associated with the erectile dysfunction agents after scouring the Adverse Event Reporting System. There have also been cases of sudden hearing loss reported in patients using Revatio (sildenafil) for pulmonary arterial hypertension. Medpage Today. 10/22/07. (Also see: Ear Involvement and Raynaud's)
Tracleer(R) Shows Clinical Benefit As Combination Therapy With Sildenafil For Pulmonary Arterial Hypertension. Data from both studies suggest that Tracleer, when given in combination with sildenafil, is well-tolerated and improves hemodynamics in PAH patients. Medical News Today. 10/24/07. (Also see: Bosentan)
Fast and efficient healing of scleroderma-associated acral ulcers with sildenafil. This case demonstrates the efficacy of sildenafil in the treatment of scleroderma-associated refractory acral ulcers. PubMed (Hautarzt) 2007 Jul 22. (Also see: Digital Ulcers)
Addition of sildenafil to bosentan monotherapy in pulmonary arterial hypertension. Addition of sildenafil after bosentan monotherapy failure improved NYHA and 6MWD in IPAH (idiopathic PAH) patients, but failed to improve either parameter in PAH-SSD (scleroderma-associated PAH) patients. Additional studies are needed to assess the tolerability and efficacy of this combination in patients with PAH-SSD. PubMed. Eur Respir J. 2006 Nov 1. (Also see: Bosentan)
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