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Severity and Prognosis for Scleroderma Pulmonary Involvement

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overview
Predictors of Morbidity and Mortality
Health Related Quality of Life Issues (HRQOL)

Overview of Severity and Prognosis for Scleroderma Pulmonary Involvement

The primary cause of scleroderma-related death today is lung involvement; it used to be kidney failure, but that risk has been reduced thanks to dialysis and other treatments.
Connective Tissue Disease-Associated Interstitial Lung Disease (CTD): A Focused Review. The prognosis of patients with CTD having respiratory failure is often quite poor, highlighting the need for prompt and thorough clinical assessments to determine the underlying etiology and implementation of appropriate therapeutic strategies. PubMed, J Intensive Care Med, 2013 Dec 25. (Also see: Connective Tissue Disease)
Computed tomography aids scleroderma lung disease prognosis. However, the team suggests that pulmonary function tests (PFTs) may be more practical than HRCT in the clinic. NewsMedical. 10/22/12.
Survival in progressive systemic sclerosis with pulmonary involvement: a single-center experience in Istanbul, Turkey. The objective of the current study was to determine survival and factors that affect survival in progressive systemic sclerosis (SSc) with pulmonary involvement. Zuhur F. Rheumatol Int. 2011 Mar 5.
Pulmonary survival study in 91 patients with systemic sclerosis (SSc). In SSc major determinant of morbidity and mortality is pulmonary complication including pulmonary interstitial lung disease and pulmonary arterial hypertension. Patients were classified as limited or diffuse subtype. In the present study, clinical manifestations of two subtypes of disease were divergent at first; however they became convergent in late stages, and this was the same as results in previous studies. Hadi Poormoghim. Rheumatology International. 23 May 2010.
Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database. Disease-related causes, in particular pulmonary fibrosis, PAH and cardiac causes, accounted for the majority of deaths in SSc. Tyndall AJ. (PubMed) Ann Rheum Dis. 2010 Jun 15. (Also see: Prognosis and Mortality and Cardiac)
Prognosis of Pulmonary Hypertension in Systemic Sclerosis (Scleroderma). Early diagnosis and treatment substantially improves the prognosis for pulmonary hypertension associated with systemic sclerosis (scleroderma). ISN.
Overview of PH Prognosis
Functional Classification of PH
Markers for Prognosis of PH
Personal Stories of Prognosis of PH

Predictors of Morbidity and Mortality

Prediction of pulmonary complications and long term survival in systemic sclerosis (SSc). This study provides data on long-term outcome of SSc and the timing and frequency of major organ complications. PubMed, Arthritis Rheumatol, 03/03/2014. (Also see: Prognosis of Pulmonary Hypertension)
I'm confused! What exactly is the difference between morbidity and mortality?

Morbidity is another term for illness. A person can have several co-morbidities simultaneously. So, morbidities can range from Alzheimer's disease to cancer to traumatic brain injury. Morbidities are NOT deaths. Prevalence is a measure often used to determine the level of morbidity in a population. New York State Department of Health.

Mortality is another term for death. A mortality rate is the number of deaths due to a disease divided by the total population. If there are 25 lung cancer deaths in one year in a population of 30,000, then the mortality rate for that population is 83 per 100,000. New York State Department of Health.

So, morbidity just sounds deadly, but mortality really is.

Health Related Quality of Life Issues (HRQOL) for Scleroderma Pulmonary Involvement

Quality of Life with Scleroderma. The quality of life (QOL) is affected any time something prevents us from maintaining our normal routine or from doing something that we enjoy. A broken arm will affect your QOL on a temporary basis, but a chronic illness may it affect it indefinitely. ISN.
Overview
QOL with Scleroderma
Symptoms and QOL
Assessing QOL
Improving on the QOL
Personal Stories
 
Go to Pulmonary Involvement Patient Stories
 

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