Sjögren's Syndrome |
| Author: Shelley Ensz. Scleroderma is highly variable. Read Disclaimer |
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What is Sjögren's Syndrome? |
 Hallmark symptoms of Sjögren's include dry eyes, dry mouth, dry vagina. Sjögren's can also cause fatigue, and it can affect the skin, lungs, heart, kidneys, muscles, and central nervous system. People can also have any of the above symptoms separately, or due to other conditions.
Ninety percent of Sjögren's patients are female. Many Sjögren's patients are undiagnosed, with an average of ten years from onset to diagnosis—for those fortunate enough to be diagnosed at all. |
| "Sjögren's may also be referred to as: Dacryosialoadenopathia atrophicans, Gougerot-Houwer-Sjögren, Gougerot-Sjögren, Keratoconjunctivitis Sicca, Keratoconjunctivitis sicca-xerostomia, Secreto-inhibitor-xerodermostenosis, and Sicca Syndrome." NORD |
| Sjögren's Syndrome About.com |
| Sjögren's Synddrome. MedicineNet.com |
| Sjögren’s syndrome, the old and the new. An extensive review the postulated aetiologies, pathogenesis and new insights related to Sjögren’s syndrome. Best Pract Res Clin Rheumatol. 2012 Feb;26(1):105-17. |
| A current perspective on Sjögren's syndrome. Recent developments are unlocking the mystery of the disease process as well as contributing to our ability to define, diagnose, and develop new treatment modalities for patients with this complex disorder. PubMed. J Calif Dent Assoc. 2011 Sep;39(9). |
| What Is Sjogren's Syndrome? What Causes Sjogren's Syndrome? Sjogren's syndrome (Sjögrens Syndrome) is a chronic disorder of the immune system - a long-term autoimmune disease - in which the patient's white blood cells attack the saliva and tear glands, leading to dry mouth and eyes because the body's tear and saliva production is reduced. Medical News Today. 09/01/11. |
| Similarities and Differences Between Primary and Secondary Sjögren's Syndrome (SS). A higher frequency of oral symptoms and parotid enlargement and stronger B cell activity (autoantibody production and lymphocyte infiltration) were observed in primary SS. Gabriela Hernández-Molina. JRheum. March 1, 2010. |
Symptoms of Sjogren's Syndrome |
| Symptoms of Sjogren's. Hallmark symptoms of Sjögren's include dry eyes, dry mouth, dry vagina. Sjögren's can also cause fatigue, and it can affect the skin, lungs, heart, kidneys, muscles, and central nervous system. People can also have any of the above symptoms separately, or due to other conditions. ISN. |
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Diagnosis of Sjogren's Syndrome |
| Diagnosis of Sjogren's Syndrome. Typical diagnostic tests for Sjogren's include Schirmer's eye test, slit-lamp test, tests measuring saliva flow, radiologic salivary scans, and salivary gland biopsy. ISN. |
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Similar and Overlapping Conditions |
| Sjogren's symptoms have been associated with other conditions, including autoimmune or collagen vascular diseases, such as thyroid disease, gastic antral vascular ectasia (watermelon stomach), systemic scleroderma, lupus, Reynold's syndrome, primary biliary cirrhosis, and rheumatoid arthritis. |
| About twenty percent of patients with systemic scleroderma also have Secondary Sjögren's Syndrome. |
| Overlap of ACA positive systemic sclerosis (SSc) and Sjögren's syndrome (SS): a distinct clinical entity with mild organ involvement but at high risk of lymphoma. This is characterized by a benign SSc clinical course but a high risk of non-Hodgkin's lymphoma. PubMed Clin Exp Rheumatol. 2013 Jan 18. |
| Sjögren's syndrome at the crossroad of polyautoimmunity. This study discloses a high prevalence of polyautoimmunity in Sjogren's Syndrome, its associated risk factors and the grouping pattern of such a condition. PubMed. J Autoimmun. 2012 Jun 30. (Also see:Multiple Autoimmune Syndrome) |
| Sjogren's thrombocytopenia. Clinically important immune-mediated cytopenia (or a combination of cytopenias) may be the first manifestation of an occult SS and have only been rarely described with Sjogren's. Kamath V J. (PubMed) Assoc Physicians India. 2011 Feb;59:114-5. |
| Coexistence of two different types of lymphoma in a patient with Sjögren's syndrome. The usefulness of the PET-CT. Sjögren syndrome is a chronic systemic autoimmune disease in which there is an increased risk of developing non-Hodgkin's lymphoma. Infante De La Torre.(PubMed) JR Rev Esp Med Nucl. 2011 Jul 5. |
| A Clinical Prediction Rule For Lymphoma Development In Primary And Secondary Sjögren's Syndrome. This study allowed us to create a prediction model which might be useful in improving the follow-up management of patients with primary and secondary Sjogren's (pSS and sSS-SSc). C. Baldini. EULAR 2011 OPO039. Ann Rheum Dis 2011;70(Suppl3):80. (Also see: Scleroderma and Cancer) |
| Watermelon stomach in a patient with primary Sjögren's syndrome. This is the first report of WS in a patient with primary SS without the presence of coexisting autoimmune disorder. Recognition of this rare, but clinically important, cause of gastrointestinal bleeding may decrease comorbidity in patients with autoimmune disorders including primary Sjögren's syndrome. Krstić M. (PubMed) Vojnosanit Pregl. 2010 Mar;67(3):256-8. (Also see: Watermelon Stomach) |
| Secondary Sjögren's Syndrome (SS) in Systemic Lupus Erythematosus (SLE) Defines a Distinct Disease Subset. The subset of patients with SLE and SS has a distinct clinical and laboratory phenotype, with a higher frequency of older white women with photosensitivity, oral ulcers, Raynaud's phenomenon, anti-Ro antibodies, and anti-La antibodies and a lower frequency of renal disease, anti-dsDNA antibodies, and anti-RNP antibodies. A. Baer. JRheum. April 1 2010. (Also see: Lupus and Overlapping Diseases) |
| Comorbidities in Patients with Primary Sjögren's Syndrome (pSS): A Registry-based Case-control Study. The prevalence of several comorbidities was increased among the patients with pSS. J. Horng-Kang. JRheum. April 1 2010. |
| Anticentromere antibody positive Sjogren's Syndrome: a retrospective descriptive analysis. A subgroup of patients with primary Sjogren's syndrome (SS) and positive anticentromere antibodies (ACA+) were recognized as having features intermediate between SS and systemic sclerosis (SSc). ACA+/SS has a clinical phenotype intermediate between ACA-/SS and SSc and shows little tendency to evolve to SSc. Vasiliki-Kalliopi K Bournia Arthritis Research & Therapy 19 March 2010. (Also see: Sjogren's) |
| Sjögren's syndrome (SS) -onset lupus (SLE) patients have distinctive clinical manifestations and benign prognosis: A case control study. Different from SLE-only patients, SS/SLE patients have distinctive clinical manifestations and benign prognosis that require less vigorous treatment with glucocorticoids and/or immunosuppressants. D. Xu. Lupus. February 1 2010. (Also see: Lupus and Overlapping Diseases) |
| Interstitial Cystitis and Systemic Autoimmune Diseases. The strongest association occurs between interstitial cystitis and Sjögren's syndrome. Nat Clin Pract Urol. 2007 Sep;4(9):484-91. (Also see: Interstitial Cystitis) |
 Scleroderma Dental Involvement Scleroderma can cause many dental problems, including small mouth, dry mouth, bone reabsorption, receding ligaments, and TMJ. ISN. |
Treatments for Sjögren's |
| Treatments for Sjogren's may consist of therapies aimed at relieving specific symptoms, such as dry eyes or dry mouth, or targeted at trying to control the underlying disease process. |
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Sjogren's Research |
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| Overview of Sjogren's Research |
| Genetics of Sjögren's syndrome in the genome-wide association era. Here we review the fundamental scientific principles employed in genome-wide association (GWA) scans as well as the limitations of this tool, and we discuss the application of GWA scans in determining genetic variants at play in complex disease. J Autoimmun. 2012 Jan 28. |
| Sjogren's Research: Antibodies |
| Sjögren's Antibodies (Anti-SS-A/Anti-SS-B). SS-A(Ro) is found in 60% to 70% of patients with Sjögren's syndrome and 30% to 40% of patients with SLE. SS-B(La) is found in 50% to 60% of Sjögren's syndrome and 10% to 15% of SLE. LabCorp. |
| Sjogren's Research: Dry Eyes |
| Antibody Protein Array Analysis of the Tear Film Cytokines. Preliminary results using tears collected from patients with Sjogren's syndrome reveal methodological advantages of protein array technology and support the concept that autoimmune-mediated dry eye disease has an inflammatory component. Li, Shimin PhD. Optometry & Vision Science. August 2008. (Also see: Autoimmune Eye Diseases) |
Online Support for Sjögren's |
| SWA Invitation Do you have a Sjögren's web site? If so, you are invited join the free international Scleroderma Webmaster's Association. |
| Sjögren's Support Email List (TalkSjo) provides support and sociability for Sjögren's patients worldwide. Dry.Org |
| Sjögren's Syndrome Medical Information List is a moderated list subscribed to by hundreds of Sjögren's patients and professionals worldwide. The main focus of the list is medical information and anything that does not have to do specifically with Sjögren's does not get posted. |
Sjögren's Patient Stories |
| Submit your Sjögren's and/or Scleroderma Story (in any language) for inclusion on SCLERO.ORG. It's as easy as writing an email, using our simple online form. ISN. |
| Annette G: MCTD, Systemic Scleroderma, Sjogren's, Chronic Kidney Disease, CFS, Fibromyalgia, Trigeminal Neuralgia, TMJ People think that because I am a nurse I have all the answers. Well guess what? I don't... |
| (Italiano) Antea: Sindrome di Sjogren e il Lupus Eritematoso Sistemico Sono Angela dalla provincia di pesaro, ho 29 anni e da ieri ho scoperto di avere la Sindrome di Sjogren... |
| More Sjogren's Personal Stories.. . |
