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Sjögren's Syndrome

Author: Shelley Ensz. Scleroderma is highly variable. Read Disclaimer
Overview
Symptoms
Diagnosis
Similar & Overlaps
Treatments
Overview
Dry Eyes
Dry Mouth
Research
Overview
Antibodies
Dry Eyes
Online Support
Personal Stories

Overview: What is Sjögren's Syndrome?

Water Fountain by Janet Paulmenn, ISN ArtistHallmark symptoms of Sjögren's include dry eyes, dry mouth, dry vagina. Sjögren's can also cause fatigue, and it can affect the skin, lungs, heart, kidneys, muscles, and central nervous system. People can also have any of the above symptoms separately, or due to other conditions.

Ninety percent of Sjögren's patients are female. Many Sjögren's patients are undiagnosed, with an average of ten years from onset to diagnosis—for those fortunate enough to be diagnosed at all.

"Sjögren's may also be referred to as: Dacryosialoadenopathia atrophicans, Gougerot-Houwer-Sjögren, Gougerot-Sjögren, Keratoconjunctivitis Sicca, Keratoconjunctivitis sicca-xerostomia, Secreto-inhibitor-xerodermostenosis, and Sicca Syndrome." NORD
Sjögren's Syndrome About.com
Sjögren's Synddrome. MedicineNet.com
New advances in the classification, pathogenesis and treatment of Sjogren's syndrome. A new set of classification criteria for Sjogren's syndrome has been suggested and significant progress has been made in understanding the activation of innate and adaptive immune responses. PubMed, Curr Opin Rheumatol, 2013 Sep;25(5):623-9.
Sjögren's syndrome, the old and the new. An extensive review the postulated aetiologies, pathogenesis and new insights related to Sjögren's syndrome. Best Pract Res Clin Rheumatol. 2012 Feb;26(1):105-17.
A current perspective on Sjögren's syndrome. Recent developments are unlocking the mystery of the disease process as well as contributing to our ability to define, diagnose, and develop new treatment modalities for patients with this complex disorder. PubMed. J Calif Dent Assoc. 2011 Sep;39(9).
What Is Sjogren's Syndrome? What Causes Sjogren's Syndrome? Sjogren's syndrome (Sjögrens Syndrome) is a chronic disorder of the immune system - a long-term autoimmune disease - in which the patient's white blood cells attack the saliva and tear glands, leading to dry mouth and eyes because the body's tear and saliva production is reduced. Medical News Today. 09/01/2011.

Symptoms of Sjogren's Syndrome

Symptoms of Sjogren's. Hallmark symptoms of Sjögren's include dry eyes, dry mouth, dry vagina. Sjögren's can also cause fatigue, and it can affect the skin, lungs, heart, kidneys, muscles, and central nervous system. ISN.
Overview
Dry Eyes
Dry Mouth
Dry Vagina
Fatigue
Liver
Nervous System
Skin
Newborn Heart Problems
Sjogren's and Pregnancy

Diagnosis of Sjogren's Syndrome

Diagnosis of Sjogren's Syndrome. Typical diagnostic tests for Sjogren's include Schirmer's eye test, slit-lamp test, tests measuring saliva flow, radiologic salivary scans, and salivary gland biopsy. ISN.
Overview of Sjogren's Diagnosis
Antibodies
Biomarkers in Saliva and Tears
Salivary Gland Biopsy
Schirmer's Test
Slit Lamp Test
Ultrasonography of Glands

Similar and Overlapping Conditions

Sjogren's symptoms have been associated with other conditions, including autoimmune or collagen vascular diseases, such as thyroid disease, gastic antral vascular ectasia (watermelon stomach), systemic scleroderma, lupus, Reynold's syndrome, primary biliary cirrhosis, and rheumatoid arthritis.
About twenty percent of patients with systemic scleroderma also have Secondary Sjögren's Syndrome.
Autoimmune Disease Linked to Estrogen Deficiency. Estrogen may have a new purpose in treating or preventing certain types of autoimmune disease, according to a study. News Fix, 08/16/2013. (Also see: Causes of Scleroderma: Hormones and Chromosomes)
Signal Hyperintensities (SH) on Brain Magnetic Resonance Imaging in Patients with Primary Sjogren Syndrome (pSS) and Frequent Episodic Tension-type Headache (FETH). Periventricular SH seem to be associated with increased platelet serotonin release in pSS patients with FETH and correlated with disease duration and might be linked with chronic immunoinflammation of low-grade intensity and vasculitis in pSS. PubMed, J Rheumatol. 2013 Jun 1.
The clinical and laboratory characteristics of Sjögren's syndrome (SS) that progresses to systemic lupus erythematosus (SLE). The SS/SLE patients had an earlier age of onset, higher incidences of arthritis, leucopenia, proteinuria and low complement levels, and lower incidences of xerostomia and interstitial lung disease compared with Primary Sjogren's Syndrome patients. PubMed, Int J Rheum Dis. 2013 Apr;16(2):173-7. (Also see: Lupus in Overlap)
Overlap of ACA positive systemic sclerosis (SSc) and Sjögren's syndrome (SS): a distinct clinical entity with mild organ involvement but at high risk of lymphoma. This is characterized by a benign SSc clinical course but a high risk of non-Hodgkin's lymphoma. PubMed, Clin Exp Rheumatol. 2013 Jan 18.
Sjögren's syndrome at the crossroad of polyautoimmunity. This study discloses a high prevalence of polyautoimmunity in Sjogren's Syndrome, its associated risk factors and the grouping pattern of such a condition. PubMed. J Autoimmun. 2012 Jun 30. (Also see:Multiple Autoimmune Syndrome)
Sjogren's thrombocytopenia. Clinically important immune-mediated cytopenia (or a combination of cytopenias) may be the first manifestation of an occult SS and have only been rarely described with Sjogren's. PubMed, Assoc Physicians India. 2011 Feb;59:114-5.
Coexistence of two different types of lymphoma in a patient with Sjögren's syndrome. The usefulness of the PET-CT. Sjögren syndrome is a chronic systemic autoimmune disease in which there is an increased risk of developing non-Hodgkin's lymphoma. PubMed, JR Rev Esp Med Nucl. 2011 Jul 5.
A Clinical Prediction Rule For Lymphoma Development In Primary And Secondary Sjögren's Syndrome. This study allowed us to create a prediction model which might be useful in improving the follow-up management of patients with primary and secondary Sjogren's (pSS and sSS-SSc). C. Baldini. EULAR 2011 OPO039. Ann Rheum Dis 2011;70(Suppl3):80. (Also see: Scleroderma and Cancer)
Red Lips Photography by Nolan LaTourelleScleroderma Dental Involvement Scleroderma can cause many dental problems, including small mouth, dry mouth, bone reabsorption, receding ligaments, and TMJ. ISN.

Treatments for Sjögren's

Treatments for Sjogren's may consist of therapies aimed at relieving specific symptoms, such as dry eyes or dry mouth, or targeted at trying to control the underlying disease process. ISN.
Treatments of Sjogren's: Overview
Treatments for Dry Eyes
Treatments for Dry Mouth
Treatment for Fatigue
Treatment for Renal Involvement

Sjogren's Research

Overview Sjogren's Research: Antibodies
Overview of Sjogren's Research
Genetics of Sjögren's syndrome in the genome-wide association era. Here we review the fundamental scientific principles employed in genome-wide association (GWA) scans as well as the limitations of this tool, and we discuss the application of GWA scans in determining genetic variants at play in complex disease. J Autoimmun. 2012 Jan 28.
Sjogren's Research: Antibodies
Sjögren's Antibodies (Anti-SS-A/Anti-SS-B). SS-A(Ro) is found in 60% to 70% of patients with Sjögren's syndrome and 30% to 40% of patients with SLE. SS-B(La) is found in 50% to 60% of Sjögren's syndrome and 10% to 15% of SLE. LabCorp.

Online Support for Sjögren's

SWA Invitation Do you have a Sjögren's web site? If so, you are invited join the free international Scleroderma Webmaster's Association.
Sjögren's Support Email List (TalkSjo) provides support and sociability for Sjögren's patients worldwide. Dry.Org
Sjögren's Syndrome Medical Information List is a moderated list subscribed to by hundreds of Sjögren's patients and professionals worldwide. The main focus of the list is medical information and anything that does not have to do specifically with Sjögren's does not get posted.

Sjögren's Patient Stories

Submit your Sjögren's and/or Scleroderma Story (in any language) for inclusion on SCLERO.ORG. It's as easy as writing an email, using our simple online form. ISN.
Annette G: MCTD, Systemic Scleroderma, Sjogren's, Chronic Kidney Disease, CFS, Fibromyalgia, Trigeminal Neuralgia, TMJ People think that because I am a nurse I have all the answers. Well guess what? I don't...
(Italiano) Antea: Sindrome di Sjogren e il Lupus Eritematoso Sistemico Sono Angela dalla provincia di pesaro, ho 29 anni e da ieri ho scoperto di avere la Sindrome di Sjogren...
More Sjogren's Personal Stories.. .
 
Go to Sjogren's Syndrome: Symptoms
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