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Symptoms and Complications of Sjogren's Syndrome

Overview
Cardiovascular
Central Nervous System
Dry Eyes
Dry Mouth
Dry Vagina
Fatigue
Liver
Skin
Newborn Heart Problems
Sjogren's and Pregnancy

Overview

Hallmark symptoms of Sjögren's include dry eyes, dry mouth, dry vagina. Sjögren's can also cause fatigue, and it can affect the skin, lungs, heart, kidneys, muscles, and central nervous system. People can also have any of the above symptoms separately, or due to other conditions.
Symptoms of Sjogren's Syndrome. Sjögren's is a systemic disease, and its symptoms are felt throughout the entire body. Sjogren's Syndrome Foundation.

Cardiovascular

Prevalence of and factors associated with increased arterial stiffness in patients with primary Sjögren's syndrome (pSS). Women with pSS had higher pulse wave velocity (PWV) than controls. PubMed, Arthritis Care Res (Hoboken), 2014 Oct 9.

Central Nervous System

Hippocampal atrophy is associated with cerebrospinal fluid anti-NR2 antibodies in patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS). Anti-NR2 antibodies cause neuronal death observed as reduced hippocampal grey matter in patients with SLE and pSS as previously demonstrated in mice with autoimmune disease. PubMed, Arthritis Rheumatol, 2014 Aug 22. (Also see: SLE Symptoms)
Diagnosis and treatment of primary Sjögren syndrome (PSS)-associated peripheral neuropathy: a six-case series. In PSS patients, a precise diagnosis is important, because the therapeutic strategy and response varies depending on the type of neuropathy. Springer, Modern Rheumatology, Sept 2013.
Severity and Neuropathic Pain symptoms in primary Sjogren's syndrome (pSS): A comparison study of seropositive and seronegative Sjogren's syndrome. Chronic pain is pervasive in both seropositive and seronegative pSS patients, while pain severity and functional impairment is greater in seronegative patients. PubMed. Arthritis Care Res (Hoboken). 2013 Jan 17.
Neurological Disorders in Primary Sjögren's Syndrome. Neurological involvement ranges from 0 to 70% among various series and may present with central nervous system and/or peripheral nervous system involvement. PubMed. Autoimmune Dis. 2012;2012:645967.

Dry Eyes

Dry eyes are a symptom of Sjogren's syndrome.
Eye Problems Pain, redness and loss of vision are important problems that require medical attention. Eye problems can warn us of other health problems as well. familydoctor.org
Primary Sjögren's syndrome (pSS) – Fatigue is an ever-present, fluctuating and uncontrollable lack of energy. Fatigue in pSS clearly differs from ordinary tiredness. Patients describe it as ever-present, fluctuating and non-relievable lack of vitality being beyond own control. Wiley Online Library, 12/13/2013. (Also see: Fatigue)
Eye Problems – Prevalence Of Eye Disorders Among Baby Boomers Feared. The population is not only aging but also growing- increasing the cases of dry eye syndrome just from the sheer numbers. The US population will add 50 million people by 2030 and about 4 million of these will have dry eyes. Star Global Tribune. 06/28/2011. (Also see: Eye Involvement)

Dry Mouth

Dry mouth is a symptom of Sjogren's syndrome.
Red Lips Photography by Nolan LaTourelleScleroderma Dental Involvement Scleroderma can cause many dental problems, including small mouth, dry mouth, bone reabsorption, receding ligaments, and TMJ. ISN.
Androgens and Integrins in Salivary Glands in Sjögren's Syndrome (SS). In SS salivary glands androgen regulation was defective, which is likely to contribute to defective outside-in signaling, acinar atrophy, and ductal cell hyperplasia. P.Parola. Journal of Rheumatology. May 1 2010.

Dry Vagina

Sjogren's Syndrome - 10 Things You Should Know. Some Sjogren's syndrome patients also experience dryness of the skin, vagina, nasal passages, and throat. About.com.

Fatigue

Primary Sjögren's syndrome (pSS) – Fatigue is an ever-present, fluctuating and uncontrollable lack of energy. Fatigue in pSS clearly differs from ordinary tiredness. Patients describe it as ever-present, fluctuating and non-relievable lack of vitality being beyond own control. PubMed, Arthritis Care Res, 2013 Dec 10. (Also see: Fatigue)

Liver

The liver is a common non-exocrine target in primary Sjögren's syndrome (1°SS): A retrospective review. Liver involvement is a common complication in 1°SS. Its presence correlates with systemic disease. We consider that this complication should be routinely sought in patients with 1°SS, especially when a positive anti-ENA or evidence of systemic inflammation is found. Mariana J Kaplan.(SpringerLink) BMC Gastroenterology, 200 Volume 2, Number 1, Pages 1-9.

Skin

Dermatologic manifestations of sjögren syndrome. Cutaneous manifestations have been underemphasized because they are often overshadowed by the more prominent sicca symptoms. However, certain skin findings are of paramount clinical and prognostic importance as they confer an increased risk for the development of life-threatening conditions. UnBound, J Cutan Med Surg, 2011 Jan-Feb; 15(1):8-14.

Newborn Heart Problems

Women with Sjögren's have a higher risk of having lupus and other autoimmune diseases, and of their newborns having heart problems.

Pregnancy

Pregnancy and fetal outcome in women with primary Sjögren's syndrome compared with women in the general population: a nested case–control study. Pregnancy occurs later in life in women with primary Sjogren's Syndrome (pSS). Mothers with pSS give birth to offspring with lower birthweight and less commonly have normal partus. PubMed. Rheumatology (Oxford). 2011 Sep;50(9):1612-7.
 
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