| Sjögren's Syndrome |
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Symptoms and Complications of Sjogren's Syndrome |
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Symptoms of Sjogren's Syndrome: Overview |
| Hallmark symptoms of Sjögren's include dry eyes, dry mouth, dry vagina. Sjögren's can also cause fatigue, and it can affect the skin, lungs, heart, kidneys, muscles, and central nervous system. People can also have any of the above symptoms separately, or due to other conditions. |
| Sjögren’s syndrome, the old and the new. An extensive review the postulated aetiologies, pathogenesis and new insights related to Sjögren’s syndrome. Best Pract Res Clin Rheumatol. 2012 Feb;26(1):105-17. (Also see: Sjogren's) |
| Clinical and Prognostic Significance of Parotid Scintigraphy in 405 Patients with Primary Sjögren's Syndrome (SS). Patients with SS presenting with severe scintigraphic involvement at diagnosis had a more pronounced autoimmune expression, a higher risk of developing systemic features and lymphoma, and a lower survival rate. M. Ramos-Casals. JRheum. January 15 2010. |
| Psychiatric disorder as clinical presentation of primary Sjogren's syndrome (pSS): two case reports. In this article, two case reports of mental disorder as clinical presentation of pSS are presented, suggesting that psychiatric manifestations in pSS can occur not only during its longitudinal course, but also at the onset of the autoimmune syndrome. L. Pelizza. Annals of General Psychiatry. April 1, 2010. |
| Articular manifestations (AMs) in primary Sjögren's syndrome (pSS): clinical significance and prognosis of 188 patients. Although AMs are frequent and usually mild in pSS, these manifestations are associated with a pluri-systemic involvement of pSS. Anne-Laure Fauchais. Rheumatology. March 18, 2010. |
| Neuropsychiatric (NP) Syndromes Common With Lupus (SLE) and Sjogren's Syndrome (PSS). Headache, cognitive dysfunction and mood disorders are common in both diseases, but otherwise there are distinct differences in NP involvement, with cerebrovascular diseases more prevalent in SLE and neuropathies more common in PSS. This indicates that some NP disease mechanisms are shared while others differ between the two diseases. E. Harboe. Annals of the Rheumatic Diseases 2009;68:1541-1546. (Also see: Lupus) |
| Hematologic Manifestations and Predictors of Lymphoma Development in Primary Sjogren's Syndrome: Clinical and Pathophysiologic Aspects. Anemia of chronic disease and hypergammaglobulinemia are common hematologic manifestations at diagnosis and during the course of pSS. Neutropenia and cryoglobulinemia at diagnosis are significantly associated with an increased risk of lymphoma development. Evangelia Baimpa, MD. Medicine. September 2009, Vol 88, Issue 5, pp 284-293. |
| Health-related quality of life (HR-QOL), employment and disability in patients with Sjögren's syndrome (SS). SS has a large impact on HR-QOL, employment and disability. J. Meijer. Rheumatology. June 24 2009. |
| Association of Severe Inflammatory Polyarthritis in Primary Sjögren's Syndrome (SS): Clinical, Serologic, and HLA (Human Leukocyte Antigen) Analysis. Severe arthritis with features resembling rheumatoid arthritis including erosive disease can occur in primary SS, particularly among those with anti-citrulline antibodies and the shared epitope (SE). K. Mohammed. JRheum. June 1 2009. |
| Hemolytic uremic syndrome (HUS) and pericarditis as early manifestations of primary Sjögren's syndrome (pSS). We describe the unusual case of a pSS patient with the initial presentation of HUS and pericarditis and a fatal progression of pulmonary hemorrhage. (SpringerLink) Hung-An Chen. Clinical Rheumatology. March 5, 2009. |
| Unstimulated whole saliva flow rate in relation to sicca symptoms in Hungary. The percentages of subjective symptoms in the questioned subjects were oral dryness, 34%; reduced salivation, 11%; mucous saliva, 15%; dysphagia, 13%; glossopyrosis, 7%; dysphonia, 31%; dysgeusia, 9%; nasal dryness, 32%; ocular dryness, 21%; itching, 40% and xeroderma, 60%. Vaginal dryness was 14%, vaginal itching was 16% in the interviewed women. Márton K. (PubMed) Oral Dis. 2008 Jul;14(5):472-7. |
Symptoms of Sjogren's Syndrome: Dry Eyes |
| Eye Problems Pain, redness and loss of vision are important problems that require medical attention. Eye problems can warn us of other health problems as well. familydoctor.org |
| Inability to Cry in Patients With Sjogren's Syndrome Affect Emotional and Mental Well-Being. Patients with Sjogren's syndrome, a systemic immune disease which affects the production of tears and saliva, reported worse mental well-being and more difficulty in identifying feelings than the healthy population. Science Daily. 05/11/11. |
| Eye Problems – Prevalence Of Eye Disorders Among Baby Boomers Feared. The population is not only aging but also growing- increasing the cases of dry eye syndrome just from the sheer numbers. The US population will add 50 million people by 2030 and about 4 million of these will have dry eyes. Matthew Bennett. Star Global Tribune. 06/28/11. (Also see: Eye Involement) |
| Dry Eyes: A Hallmark Symptom of Sjögren's Syndrome. Dry eyes can lead to ocular surface discomfort, often described as feelings of dryness, burning, a sandy/gritty sensation, or itchiness. Visual fatigue, sensitivity to light, and blurred vision are also characteristic of dry eye. Sjogren's Syndrome Foundation. 2009. |
| Chronic Dry Eye Information: Prevalence of Chronic Dry Eye. Some estimates place the prevalence of Chronic Dry Eye at more than 3 million people in the United States. Other sources indicate that the prevalence may be higher – with as many as 23 million people frequently experiencing dry eye. Focus on Dry Eye. 2009. |
| Prevalence and risk factors of dry eye syndrome. Systemic diseases were diagnosed in 36% of female cases with dry eye syndrome, including 22.3% rheumatoid arthritis and 9.8% Sjogren's Syndrome. 46.6% of male patients had systemic diseases: 32% rheumatoid arthritis, 7% Sjogren's Syndrome. PubMed. Przegl Epidemiol. 2004;58(1):227-33. |
Symptoms of Sjogren's Syndrome: Dry Mouth |
 Scleroderma Dental Involvement Scleroderma can cause many dental problems, including small mouth, dry mouth, bone reaborption, receding ligaments, and TMJ. ISN. |
| Androgens and Integrins in Salivary Glands in Sjögren's Syndrome (SS). In SS salivary glands androgen regulation was defective, which is likely to contribute to defective outside-in signaling, acinar atrophy, and ductal cell hyperplasia. P.Parola. Journal of Rheumatology. May 1 2010. |
| Impact of primary Sjogren's syndrome (SS) on smell and taste: effect on quality of life. Clinically important impairment of chemosensory perception occurred in the SS group compared with age- and gender-matched controls. Assessment using SF-12 suggests that this impairment contributed to the reduced health-related QoL that characterized these individuals. Kamel UF. (PubMed) Rheumatology (Oxford). 2009 Dec;48(12):1512-4. |
| Implants in Patients with Sjogren's Syndrome? I have a sixty-two-year-old female patient with Sjogren's syndrome. Has anyone had the experience placing implants into people with Sjogren's syndrome. OsseoNews. 05/05/08. (Also see: Dental Involvement) |
| Oral Manifestations of Sjögren's Syndrome. Saliva plays an essential role in numerous functions of the mouth. Xerostomia can be caused by medications, chronic diseases like Sjögren's syndrome, and medical treatments, such as radiation therapy and bone marrow transplant. J Dent Res 87(4):308-318, 2008. |
| Use of the rotational path removable partial denture concept in a Kennedy Class II patient: a case report. The rotational path removable partial denture is an underutilized option for the esthetic replacement of missing teeth. It should be considered as an option in both tooth-borne and Kennedy Class II situations. Donovan T. (PubMed) J Esthet Restor Dent. 2008;20(5):294-8; discussion 299. |
Symptoms of Sjogren's Syndrome: Dry Vagina |
| Caring for women living with Sjögren's syndrome. A chronic, autoimmune condition, Sjögren's syndrome affects mostly women and leads to visual, vocal, and vaginal problems related to dryness. |
| Vaginal Lubrication in Women with Scleroderma and Sjogren's Syndrome. Sexual difficulties are often experienced by women with scleroderma, particularly those with Sjogren's syndrome. Expired link. Sexuality and Disability, Vol. 17, No. 2, ISSN 0146-1044, Kluwer Academic, Summer 1999. (Also see: Sexuality and Scleroderma and Shelley Ensz) |
Symptoms of Sjogren's Syndrome: Fatigue |
| Sleepiness or fatigue? Can we detect treatable causes of tiredness in primary Sjögren's syndrome (pSS)? This is the first study demonstrating not only the presence of disturbed sleep, but also that nightly musculoskeletal pain and other sleep disturbing factors and anxiety significantly influence fatigue in pSS. L. Theander. Rheumatology Advance Access. March 22 2010. (Also see: Causes of Fatigue) |
| The Effect of Modafinil on Fatigue and Cognitive Function in Patients with Sjögren's Syndrome (SS). Modafinil may represent a new and effective approach to treating two of the most debilitating clinical problems faced by SS patients. Thomas C. Namey. 1097/329. ACR 2007. (Also see: Fatigue) |
Complication: Liver Involvement |
| The liver is a common non-exocrine target in primary Sjögren's syndrome (1°SS): A retrospective review. Liver involvement is a common complication in 1°SS. Its presence correlates with systemic disease. We consider that this complication should be routinely sought in patients with 1°SS, especially when a positive anti-ENA or evidence of systemic inflammation is found. Mariana J Kaplan.(SpringerLink) BMC Gastroenterology, 200 Volume 2, Number 1, Pages 1-9. |
Symptoms of Sjogren's Syndrome: Nervous System |
| Neurological Disorders in Primary Sjögren's Syndrome. Neurological involvement ranges from 0 to 70% among various series and may present with central nervous system and/or peripheral nervous system involvement. PubMed. Autoimmune Dis. 2012;2012:645967. |
| Allogenic hematopoietic stem cell transplantation (HSCT) in pemphigus vulgaris: a single-center experience. Drug-resistant Pemphigus Vulgaris can be successfully and safely treated by allogeneic HSCT. Indian J Dermatol. 2012 Jan;57(1):9-11. (Also see: Pemphigus Vulgaris) |
| Central nervous system (CNS) involvement in Sjögren's syndrome (pSS): unusual, but not unremarkable—clinical, serological characteristics and outcomes in a large cohort of Italian patients. CNS involvement represents a rare but not negligible complication of pSS. A. Massara. Rheumatology Advance Access. May 5 2010. |
| Clinical manifestations of neurological involvement in primary Sjögren's syndrome (pSS). Our observations suggest that a number of mechanisms can be attributed to neurological involvements in pSS rather than just the mechanisms previously described (i.e., vasculitis and ganglioneuronitis). Presumably, specific autoantibodies may directly induce injury of the nervous system. (SpringerLink) T. Gono. Clinical Rheumatology. April 15 2010. |
| Intravenous immunoglobulin treatment for painful sensory neuropathy associated with Sjögren's syndrome. IVIg might be an effective treatment for pain in Sjögren's syndrome-associated neuropathy. Further studies should be done in a controlled, blind study. Morozumi S. (PubMed) J Neurol Sci. 2009 Apr 15;279(1-2):57-61. 2009 Jan 24. (Also see: Neurological Involvement) |
| Neuropsychiatric (NP) syndromes in patients with Systemic Lupus Erythematosus (SLE) and primary Sjögren's Syndrome (PSS): A comparative population-based study. Headache, cognitive dysfunction, and mood disorders are common in both diseases, but otherwise there are distinct differences in NP involvement with cerebrovascular disease more prevalent in SLE, and neuropathies more common in PSS. (ARD Online) E. Harboe. Ann Rheum Dis. October 17, 2008. (Also see: Lupus) |
| Autonomic nervous symptoms in primary Sjögren's syndrome (pSS). pSS patients showed subjective and objective signs of both a parasympathetic and a sympathetic dysfunction. However, autonomic dysfunction symptoms showed limited associations with objective autonomic nervous function as well as other clinical features of the disease. T. Mandl. Rheumatology Access Online. April 14,2008. |
Sjogren's Syndrome and Dermatofibromas |
| Dermatologic manifestations of sjögren syndrome. Cutaneous manifestations have been underemphasized because they are often overshadowed by the more prominent sicca symptoms. However, certain skin findings are of paramount clinical and prognostic importance as they confer an increased risk for the development of life-threatening conditions. Kittridge A. (UnBound) J Cutan Med Surg 2011 Jan-Feb; 15(1):8-14. |
| Multiple dermatofibromas in a patient with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). We report a case of multiple dermatofibromas in a patient with SLE and SS. As these tumors appeared during the remission stage of SLE, they might have been under immunosuppressive conditions caused by immunosuppressing agents rather than collagen disease itself. (SpringerLink) T. Fujisawa. 03/11/10. (Also see: Lupus) |
Sjogren's Syndrome and Newborn Heart Problems |
| Women with Sjögren's have a higher risk of having lupus and other autoimmune diseases, and of their newborns having heart problems. |
| An expanded phenotype of maternal SSA/SSB antibody-associated fetal cardiac disease. Conventional manifestations of fetal Sjogren's antibodies (SSA/SSB) associated cardiac disease include atrioventricular block (AVB), transient sinus bradycardia, endocardial fibroelastosis (EFE) and dilated cardiomyopathy. Cuneo BF. (PubMed) J Matern Fetal Neonatal Med. 2009 Mar;22(3):233-8. |
Sjogren's Syndrome and Pregnancy |
| Sjogren's syndrome diagnosed in pregnancy: a case report. Since the presence of autoantibodies against SS-A and SS-B are reported to accompany congenital heart block, the primary goal of therapy should be preventing this untoward effect of the disease. Close monitoring during pregnancy is mandatory to detect preeclampsia, intrauterine growth retardation and preterm labor. PubMed. J Reprod Med. 2005 Jan;50(1):67-70. |
