| Sjögren's Syndrome |
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Symptoms and Complications of Sjogren's Syndrome |
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Symptoms of Sjogren's Syndrome: Overview |
| Hallmark symptoms of Sjögren's include dry eyes, dry mouth, dry vagina. Sjögren's can also cause fatigue, and it can affect the skin, lungs, heart, kidneys, muscles, and central nervous system. People can also have any of the above symptoms separately, or due to other conditions. |
| Clinical and Prognostic Significance of Parotid Scintigraphy in 405 Patients with Primary Sjögren's Syndrome (SS). Patients with SS presenting with severe scintigraphic involvement at diagnosis had a more pronounced autoimmune expression, a higher risk of developing systemic features and lymphoma, and a lower survival rate. M. Ramos-Casals. JRheum. January 15 2010. |
| Psychiatric disorder as clinical presentation of primary Sjogren's syndrome (pSS): two case reports. In this article, two case reports of mental disorder as clinical presentation of pSS are presented, suggesting that psychiatric manifestations in pSS can occur not only during its longitudinal course, but also at the onset of the autoimmune syndrome. L. Pelizza. Annals of General Psychiatry. April 1, 2010. |
| Articular manifestations (AMs) in primary Sjögren's syndrome (pSS): clinical significance and prognosis of 188 patients. Although AMs are frequent and usually mild in pSS, these manifestations are associated with a pluri-systemic involvement of pSS. Anne-Laure Fauchais. Rheumatology. March 18, 2010. |
Symptoms of Sjogren's Syndrome: Dry Eyes |
| Eye Problems Pain, redness and loss of vision are important problems that require medical attention. Eye problems can warn us of other health problems as well. familydoctor.org |
| Inability to Cry in Patients With Sjogren's Syndrome Affect Emotional and Mental Well-Being. Patients with Sjogren's syndrome, a systemic immune disease which affects the production of tears and saliva, reported worse mental well-being and more difficulty in identifying feelings than the healthy population. Science Daily. 05/11/11. |
| Eye Problems – Prevalence Of Eye Disorders Among Baby Boomers Feared. The population is not only aging but also growing- increasing the cases of dry eye syndrome just from the sheer numbers. The US population will add 50 million people by 2030 and about 4 million of these will have dry eyes. Matthew Bennett. Star Global Tribune. 06/28/11. (Also see: Eye Involement) |
Symptoms of Sjogren's Syndrome: Dry Mouth |
 Scleroderma Dental Involvement Scleroderma can cause many dental problems, including small mouth, dry mouth, bone reabsorption, receding ligaments, and TMJ. ISN. |
| Androgens and Integrins in Salivary Glands in Sjögren's Syndrome (SS). In SS salivary glands androgen regulation was defective, which is likely to contribute to defective outside-in signaling, acinar atrophy, and ductal cell hyperplasia. P.Parola. Journal of Rheumatology. May 1 2010. |
Symptoms of Sjogren's Syndrome: Dry Vagina |
| Caring for women living with Sjögren's syndrome. A chronic, autoimmune condition, Sjögren's syndrome affects mostly women and leads to visual, vocal, and vaginal problems related to dryness. |
| Vaginal Lubrication in Women with Scleroderma and Sjogren's Syndrome. Sexual difficulties are often experienced by women with scleroderma, particularly those with Sjogren's syndrome. Expired link. Sexuality and Disability, Vol. 17, No. 2, ISSN 0146-1044, Kluwer Academic, Summer 1999. (Also see: Sexuality and Scleroderma and Shelley Ensz) |
Symptoms of Sjogren's Syndrome: Fatigue |
| Sleepiness or fatigue? Can we detect treatable causes of tiredness in primary Sjögren's syndrome (pSS)? This is the first study demonstrating not only the presence of disturbed sleep, but also that nightly musculoskeletal pain and other sleep disturbing factors and anxiety significantly influence fatigue in pSS. L. Theander. Rheumatology Advance Access. March 22 2010. (Also see: Causes of Fatigue) |
Complication: Liver Involvement |
| The liver is a common non-exocrine target in primary Sjögren's syndrome (1°SS): A retrospective review. Liver involvement is a common complication in 1°SS. Its presence correlates with systemic disease. We consider that this complication should be routinely sought in patients with 1°SS, especially when a positive anti-ENA or evidence of systemic inflammation is found. Mariana J Kaplan.(SpringerLink) BMC Gastroenterology, 200 Volume 2, Number 1, Pages 1-9. |
Symptoms of Sjogren's Syndrome: Nervous System |
| Severity and Neuropathic Pain symptoms in primary Sjogren's syndrome (pSS): A comparison study of seropositive and seronegative Sjogren's syndrome. Chronic pain is pervasive in both seropositive and seronegative pSS patients, while pain severity and functional impairment is greater in seronegative patients. Pub Med. Arthritis Care Res (Hoboken). 2013 Jan 17. |
| Severity and Neuropathic Pain symptoms in primary Sjogren's syndrome (pSS): A comparison study of seropositive and seronegative Sjogren's syndrome. Chronic pain is pervasive in both seropositive and seronegative pSS patients, while pain severity and functional impairment is greater in seronegative patients. Pub Med. Arthritis Care Res (Hoboken). 2013 Jan 17. |
| Neurological Disorders in Primary Sjögren's Syndrome. Neurological involvement ranges from 0 to 70% among various series and may present with central nervous system and/or peripheral nervous system involvement. PubMed. Autoimmune Dis. 2012;2012:645967. |
| Central nervous system (CNS) involvement in Sjögren's syndrome (pSS): unusual, but not unremarkable—clinical, serological characteristics and outcomes in a large cohort of Italian patients. CNS involvement represents a rare but not negligible complication of pSS. A. Massara. Rheumatology Advance Access. May 5 2010. |
| Clinical manifestations of neurological involvement in primary Sjögren's syndrome (pSS). Our observations suggest that a number of mechanisms can be attributed to neurological involvements in pSS rather than just the mechanisms previously described (i.e., vasculitis and ganglioneuronitis). Presumably, specific autoantibodies may directly induce injury of the nervous system. (SpringerLink) T. Gono. Clinical Rheumatology. April 15 2010. |
Sjogren's Syndrome and Dermatofibromas |
| Dermatologic manifestations of sjögren syndrome. Cutaneous manifestations have been underemphasized because they are often overshadowed by the more prominent sicca symptoms. However, certain skin findings are of paramount clinical and prognostic importance as they confer an increased risk for the development of life-threatening conditions. Kittridge A. (UnBound) J Cutan Med Surg 2011 Jan-Feb; 15(1):8-14. |
| Multiple dermatofibromas in a patient with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). We report a case of multiple dermatofibromas in a patient with SLE and SS. As these tumors appeared during the remission stage of SLE, they might have been under immunosuppressive conditions caused by immunosuppressing agents rather than collagen disease itself. (SpringerLink) T. Fujisawa. 03/11/10. (Also see: Lupus) |
Sjogren's Syndrome and Newborn Heart Problems |
| Women with Sjögren's have a higher risk of having lupus and other autoimmune diseases, and of their newborns having heart problems. |
| An expanded phenotype of maternal SSA/SSB antibody-associated fetal cardiac disease. Conventional manifestations of fetal Sjogren's antibodies (SSA/SSB) associated cardiac disease include atrioventricular block (AVB), transient sinus bradycardia, endocardial fibroelastosis (EFE) and dilated cardiomyopathy. Cuneo BF. (PubMed) J Matern Fetal Neonatal Med. 2009 Mar;22(3):233-8. |
Sjogren's Syndrome and Pregnancy |
| Sjogren's syndrome diagnosed in pregnancy: a case report. Since the presence of autoantibodies against SS-A and SS-B are reported to accompany congenital heart block, the primary goal of therapy should be preventing this untoward effect of the disease. Close monitoring during pregnancy is mandatory to detect preeclampsia, intrauterine growth retardation and preterm labor. PubMed. J Reprod Med. 2005 Jan;50(1):67-70. |
