| Sjögren's Syndrome |
| This page was written by Shelley Ensz, and has not yet been medically edited. Scleroderma (SD) affects everyone differently. See Disclaimer. |
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Treatments for Symptoms of Sjogren's Syndrome
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| Overview of Treatments for Sjogren's |
| Treatments for Sjogren's may consist of therapies aimed at relieving specific symptoms, such as dry eyes or dry mouth, or targeted at trying to control the underlying disease process. |
| Clinical Trials: Sjögren's Syndrome. CenterWatch |
| Dry.Org - Internet Resources for Sjögren's Syndrome Dry.Org |
| Is Your Skin Dry? Living in the Rockies can produce dry and itchy skin. Lotion will often do the trick. However, for some people dry skin can mean something else - Sjogren’s syndrome. Hager, Angela. Cherry Creek News. 04/26/09. |
| Treatment of sicca symptoms with hydroxychloroquine (Plaquenil) in patients with Sjögren's syndrome. This retrospective study was performed in order to evaluate the efficacy of HCQ for glandular function, i.e. saliva and tear production. HCQ treatment led to a beneficial effect on xerostomia in patients with pSS who lack severe organ manifestations. Markus Rih. Rheumatology. May 11, 2009. |
Lack of efficacy of etanercept in Sjögren’s syndrome correlates with failed suppression of TNF{alpha} and systemic immune activation. Etanercept is an ineffective therapeutic agent in pSS consistent with the absence of suppression of TNF and other indicators of immune activation. Ann Rheum Dis. 15 January 2008. |
| A case of systemic sclerosis and sjogren's syndrome with cardiac tamponade due to steroid-responsive pericarditis. Pericarditis due to SSc has been reported unresponsive to steroid therapy, but several cases of steroid responsive pericarditis due to SSc or SjS have been reported. PubMed. Arerugi. 2006 Jul;55(7):827-31. (Also see: Cardiac Involvement) |
| Treatments for Dry Eyes |
| Dry Eyes: Artificial Tears, Dry Eyes, Tears Naturale, Refresh, Refresh Plus, HypoTears, Lacrisert artificial tear inserts. |
| Gen-Teal Gel by CIBA Vision is an over-the-counter gel for dry eyes. It is best used at night, or along with liquid drops, as it can cause blurriness. |
| Management of Ocular Surface Inflammation in Sjogren Syndrome. Anti-inflammatory therapy in primary Sjogren syndrome significantly improved subjective symptoms and objective ocular signs; however, we did not find evidence that anti-inflammatory treatment increases tear production in patients with Sjogren syndrome. Cornea. 26 Supplement 1:S13-S15, October 2007. |
| Current treatments of xerophthalmia in Sjogren's syndrome. The development of topical cyclosporine and other immunomodulating agents is the most relevant progress in the treatment of keratoconjunctivitis sicca in Sjogren's syndrome. PubMed. Rev Med Interne. 2004 May;25(5):376-382. |
| Therapeutic effect of cevimeline on dry eye in patients with Sjogren's syndrome: a randomized, double-blind clinical study. These results indicate that cevimeline, 20 mg three times daily, is safe and effective in improving symptoms of dry eye in patients with SS. Additional studies, with larger patient populations, are needed to further assess the effectiveness of cevimeline for dry eye. PubMed. Am J Ophthalmol. 2004 Jul;138(1):6-17. |
| Treatments for Dry Mouth |
| Dry Mouth: Biotene products such as toothpaste, mouthwash, and gel; Salivert, Optimoist, Saliva Substitute, Moi-Stir, and Salix Lozenges. |
| Dental Involvement ISN. |
| Evoxac was approved in the U.S. in January 2000 for treatment of dry mouth in patients with Sjögren's. CenterWatch |
| Green tea may delay onset of type 1 diabetes. A powerful antioxidant in green tea may prevent or delay the onset of type 1 diabetes. They found it also worked well in their original disease focus, as it reduced the severity and delayed onset of salivary gland damage associated with Sjogren's syndrome, which has no known cure. (GEN) EurekAlert!. 10/23/08. (Also see: Diabetes) |
| Green tea may help prevent autoimmune diseases. Green tea may help protect against autoimmune disease. Researchers studied an animal model for type I diabetes and primary Sjogren's Syndrome. Further study could help determine green tea's protective role in other autoimmune diseases, including lupus, psoriasis, scleroderma and rheumatoid arthritis. EurekAlert! 04/19/07. (Also see: Diabetes and Alternative Therapies) |
| Treatments for Fatigue |
| Reduction of fatigue in Sjögren syndrome (SS) with rituximab: results of a randomised, double-blind, placebo-controlled pilot study. This is the first double blind study of rituximab in primary SS to show benefit; further studies are justified. Dass S. (PubMed) Ann Rheum Dis. 2008 Nov;67(11):1541-4. |
| Treatments for Renal Involvment |
| Renal Involvement and Followup of 130 Patients with Primary Sjögren's Syndrome (pSS). The combination of corticosteroids and immunosuppressors significantly improves the renal function of patients with pSS. J Rheumatol 2008;35:278-84. |
