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Janey Willis, ISN News GuideHello, I am Janey Willis, ISN News Manager and ISN Asst. Webmaster. David Becker, ISN Assistant News Guide researches our Autoimmune News section. Jeannie McClelland, ISN Assistant News Guide, researches Scleroderma Medical and Media News. Assistant News Guides Lisa Bulman and Judy Tarro post these stories to our Sclero Forums. Stephen Dickson prepares our RSS Newsfeed.
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May 2007
Complement receptor 3 sends a signal to dampen the immune system. Researchers reported that complement receptor 3 (CR3), a protein found on cell surfaces, inhibits dendritic cells, the sentinels of the immune system, from setting off an alarm signal that brings on a full immune response. News-Medical.Net 05/16/07. (Also see: Causes of Scleroderma: B and T Cells, and Dendritic Cells )
Natural Immune-control System May Aid Treatment Of Autoimmune Disease And Tissue Rejection. "Our findings suggest that it is possible to use antibodies to trigger the body's own mechanism for suppressing the immune response," Cantor remarks. "The results serve as a proof of principle that this approach can be applied to the treatment of conditions characterized by an excessive or unwanted immune response." Science Daily. 05/17/07. (Also see: Causes of Scleroderma: Natural Killer Cells )
Immunization Against Type 1 Diabetes - Mice Successfully Treated. Researchers in Toulouse (France) and Berlin-Buch have successfully treated type 1 diabetic mice with a vaccination. The researchers showed that, in principle, it is possible to treat autoimmune diseases by inducing "active tolerance". That means activating the immune system so that it no longer attacks the body's own structures, but instead protects them from the immune attack. Medical News Today. 05/24/07. (Also see: Diabetes and Causes of Scleroderma: B and T cells )
Measurement of Antinuclear Antibodies by Multiplex Immunoassay: A Prospective, Multicenter Clinical Evaluation. These results suggest that patterns of autoantibodies detected by multiplex immunoassay testing, when analyzed by an interpretative algorithm, are useful in the evaluation of patients with CTD in situations of high disease prevalence. T he Journal of Rheumatology. Vol 34 No 5 May 2007. (Also see: Antibodies )
Glucosamine-like dietary supplement suppresses autoimmune response in multiple sclerosis and type-1 diabetes mellitus. A glucosamine-like dietary supplement has been found to suppress the damaging autoimmune response seen in multiple sclerosis and type-1 diabetes mellitus, according to Univerisity of California, Irvine health sciences researchers. News-Medical Net. 05/16/07. (Also see: Causes of Scleroderma: T cells, Diabetes, and MS )
Why Should Rheumatologists Consider Vitamin D Supplementation for their Patients? Given the low cost of vitamin D, its excellent tolerability, combined musculoskeletal- and suggested antiinflammatory/ cardio-vascular benefits, vitamin D supplementation holds a significant public health potential. IngentaConnect. Current Rheumatology Reviews, Vol 3, No 2, May 2007, pp. 129-134(6). (Also see: Causes of Scleroderma: Vitamin D Deficiency and Rheumatoid Arthritis )
Catastrophic Antiphospholipid Syndrome (CAPS) and Sepsis. A Common Link? Catastrophic APS resembles severe sepsis in its acute presentation. Iinfections are the best known triggers of CAPS. This emphasizes the need for early diagnosis and aggressive antibiotic treatment as soon as infection is suspected in both classic APS and CAPS patients. The Journal of Rheumatology. Editorial. VOL 34: NO. 5 MAY 2007. (Also see: APS )
Molecule That Destroys Bone Also Protects It. The component, IL-17, was recognized only in the past 18 months to be a primary cause of bone destruction and inflammation in autoimmune diseases. "We know now that almost all autoimmune diseases, at least in the mouse model, are caused by TH-17 cells." Innovations Report. 05/09/07. (Also see: Causes of Scleroderma: Cytokines and Autoimmune Diseases )
Frequency of rheumatic diseases in patients with autoimmune thyroid disease (ATD). The frequency of rheumatic diseases seems to be higher in patients suffering from ATD. Initial evaluation and a regular checking for rheumatic diseases in patients suffering from ATD were recommended. IngentaConnect. Rheumatology International, Vol 27, No 6, April 2007, pp. 575-577(3). (Also see: Thyroid Disease )
Autologous hematopoietic stem cell transplantation in systemic lupus erythematosus patients with cardiac dysfunction: feasibility and reversibility of ventricular and valvular dysfunction with transplant-induced remission. These data suggest that auto-HSCT is feasible in selected patients with lupus-related cardiac dysfunction, and with control of disease activity, may improve. PubMed. Bone Marrow Transplant. 2007 May 7. (Also see: Lupus and Stem Cell Transplants )
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