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November 2013 Autoimmune News

What is next after the genes for autoimmunity? Making accurate predictions for most autoimmune diseases is an ambitious challenge, since the understanding of these pathologies is far from complete. BMC Medicine 2013, 11:197. (Also see Autoimmunity)

Topiramate for neuropathic pain and fibromyalgia in adults. Topiramate is without evidence of efficacy in diabetic neuropathic pain, the only neuropathic condition in which it has been adequately tested. Despite the strong potential for bias, no difference in efficacy between topiramate and placebo was apparent. PubMed, Cochrane Database Syst Rev, 2013 Aug 30. (Also see Fibromyalgia).

Non-pharmacological interventions for fatigue in rheumatoid arthritis. This review provides some evidence that physical activity and psychosocial interventions provide benefit in relation to self-reported fatigue in adults with rheumatoid arthritis. There is currently insufficient evidence of the effectiveness of other non-pharmacological interventions. PubMed, Cochrane Database Syst Rev, 2013 Aug 23. (Also see Rheumatoid Arthritis Treatments).

Impaired Health Status and the Effect of Pain and Fatigue on Functioning in Clinical Trial Patients with Systemic Lupus Erythematosus. Improvements in patient-reported pain or fatigue correlated with improvements in overall health. Patient assessments offer a unique perspective on treatment outcomes. Patient-reported outcomes add value in understanding clinical trial treatment benefits. PubMed, J Rheumatol, 2013 Oct 1. (Also see Systemic Lupus Erythematosus Research)

Interferons (IFN) in Sjögrenís syndrome: genes, mechanisms, and effects. Dysregulation of IFN pathways is an important feature that can be potentially used as a serum biomarker for diagnosis and targeting of new treatments in this complex autoimmune disease. Frontiers in Immunology, 20 September 2013. (Also see Sjögren's Treatments)

Recognition of new citrulline containing peptide epitopes by autoantibodies produced in vivo and in vitro by B cells of Rheumatoid arthritis patients. Anti-citrullinated peptide/protein antibodies (ACPAs) are highly sensitive and specific markers of rheumatoid arthritis (RA). Identification of peptide epitopes that may detect different subgroups of RA patients might have diagnostic and prognostic significance. Immunology, 10/04/2013. (Also see Rheumatoid Arthritis)

The importance of early treatment for the prognosis of rheumatoid arthritis (RA). To improve the clinical outcome of RA, efforts should be directed towards diagnosing RA earlier and introducing disease-modifying antirheumatic drugs (DMARD) therapy immediately after the diagnosis has been made. PubMed, Swiss Med Wkly, 2013 Sep 19. (Also see Rheumatoid Arthritis Treatments)

Isokinetic muscle performance of the hip and ankle muscles in women with fibromyalgia (FMS). Muscle strength and muscle fatigue seem to decrease in FMS patients' both proximal and distal lower extremity muscles. International Journal of Rheumatic Diseases, 16 Oct 2013. (Also see Fibromyalgia)

Irritable bowel syndrome (IBS)-type symptoms in female patients with mild systemic lupus erythematosus (SLE): frequency, related factors and quality of life. IBS-type symptoms are highly prevalent among women with SLE and are associated with fibromyalgia (FM) and depression. SLE+IBS patients had worse quality of life (HRQOL) vs Non-IBS SLE, independently of FM status. Treating IBS symptoms may improve HRQOL in women with SLE. PubMed, Neurogastroenterol Motil, 2013 Sep 25. (Also see Systemic Lupus Erythematosus, Fibromyalgia, and Depression)

Concomitant sarcoidosis and a connective tissue disease (CTD). A significant portion of patients with CTDs and sarcoidosis may actually not have the latter disease and the diagnosis of a concomitant connective tissue disease and sarcoidosis must be made with extreme caution. PubMed, Respir Med, 2013 Sep;107(9):1453-9. (Also see Sarcoidosis and Connective Tissue Disease)

Go to Autoimmune News: October 2013
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