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February 2014 Autoimmune News

Distinct antibody profile: a clue to primary antiphospholipid syndrome (PAPS) evolving into systemic lupus erythematosus (SLE)? The detection of a distinct subgroup of lupus-associated autoantibody in PAPS patients seems to be a hint to overt SLE disease, particularly in those patients with young age at diagnosis. PubMed, Clin Rheumatol, 2014 Jan 14. (Also see Antiphospholipid Syndrome and Systemic Lupus Erythematosus Antibodies)

Periodontitis treatment improves systemic lupus erythematosus response to immunosuppressive therapy. Periodontal disease treatment seems to have a beneficial effect in controlling disease activity in SLE patients under immunosuppressive therapy and therefore, management of this modifiable risk factor is recommended. PubMed, Clin Rheumatol, 2014 Jan 11. (Also see Systemic Lupus Erythematosus Treatments and Immunosuppressants)

Psoriasis beyond the skin: an expert group consensus on the management of psoriatic arthritis and common co-morbidities in patients with moderate-to-severe psoriasis. Useful and practical guidance for the detection and management of common co-morbidities in patients with moderate-to-severe psoriasis. PubMed, J Eur Acad Dermatol Venereol, 2013 Dec 24. (Also see Psoriasis)

The impact of thyroid autoimmunity on arterial stiffness in postmenopausal patients with fibromyalgia (FB). Age, functional status and presence of thyroidperoxidase autoantibody were significantly associated with increased arterial stiffness in postmenopausal FM patients. PubMed, Int J Rheum Dis, 2014 Jan 11. (Also see Fibromyalgia)

Mayo Study Finds Shoulder Replacement Eases Pain, Improves Motion in Rheumatoid Arthritis Patients. Despite surgical challenges with some rheumatoid arthritis patients, the procedure improves range of motion and reduces pain in nearly all cases, especially for those with intact rotator cuffs. Mayo Clinic News Network, 01/13/2014. (Also see Rheumatoid Arthritis Treatments)

Methotrexate (MTX) in systemic lupus erythematosus (SLE). The use of MTX is associated with significant reductions in SLE Disease Activity Index and the average dose of corticosteroids in adult patients with SLE. PubMed, Lupus, 2014 Jan 7. (Also see Systemic Lupus Erythematosus Treatments and Methotrexate)

Lymphoma risk in systemic lupus: effects of disease activity versus treatment. There was a suggestion of higher lymphoma risk with exposure to cyclophosphamide and high cumulative steroids although disease activity itself was not clearly associated with lymphoma risk. PubMed, Ann Rheum Dis, 2014 Jan 1;73(1):138-42. (Also see Systemic Lupus Erythematosus Symptoms and Lymphoma)

Renal involvement in antiphospholipid syndrome (APS). This article reviews the range of renal abnormalities associated with APS, and their diagnosis and treatment options. PubMed, Curr Rheumatol Rep, 2014 Feb;16(2):397. (Also see Antiphospholipid Syndrome)

New Tests to Detect Antiphospholipid Antibodies: Anti-Domain I Beta-2-Glycoprotein-I Antibodies. Anti-DI antibodies are strongly positively correlated with thrombotic and pregnancy manifestations, enabling identification of patients at higher risk of clinical events. Springer Link, January 2014. (Also see Antiphospholipid Syndrome)

The role of cardiovascular activity in fibromyalgia (FM) and conditioned pain modulation. Reduced cardiovascular reactivity to pain could have important involvement in diminished endogenous pain inhibition efficacy and FM pathophysiology. PubMed, Pain, 2013 Dec 15. (Also see Fibromyalgia)

Go to Autoimmune News: January 2014
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