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March 2014 Autoimmune News

Diagnosis and management of neuropsychiatric SLE (NPSLE). Although the prognosis is variable, studies suggest a more favourable outcome for primary NPSLE manifestations compared with neuropsychiatric events attributable to non-SLE causes. PubMed, Nat Rev Rheumatol, 2014 Feb 11. (Also see Systemic Lupus Erythematosus Symptoms)

Pathogenesis and prevention of rheumatic disease: focus on preclinical rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). This review focuses on the preclinical stages of RA and SLE, as our current understanding of these diseases can be used to present an overall model of the development of autoimmune rheumatic diseases that might ultimately be used to develop screening programmes and preventive strategies. PubMed, Nat Rev Rheumatol, 2014 Feb 11. (Also see Systemic Lupus Erythematosus Causes and Rheumatoid Arthritis Causes)

Mesenchymal Stem Cells (MSC), Autoimmunity & Rheumatoid Arthritis. A better understanding of the link between these cells and their biology could be a key to developing novel MSC based strategies for therapy. PubMed, QJM, 2014 Feb 10. (Also see Rheumatoid Arthritis Causes and Autoimmunity)

Diagnosis and classification of the antiphospholipid syndrome (APS). At least one clinical (vascular thrombosis or pregnancy morbidity) and one laboratory (anticardiolipin antibodies, lupus anticoagulant or anti-2-glycoprotein I antibodies) criterion had to be met for the classification of APS. PubMed, J Autoimmun, 2014 Jan 22. (Also see Antiphospholipid Syndrome)

Hemostatic and Fibrinolytic Changes Are Related to Inflammatory Conditions in Patients with Psoriatic Arthritis (PsA) — Effect of Different Treatments. Tumor necrosis factor (TNF)-a inhibitors brought about a significant improvement of hemostatic and fibrinolytic balance in subjects with PsA. Maximal changes were found in patients achieving minimal disease activity (MDA.) PubMed, J Rheumatol, 2014 Feb 15. (Also see Treatments for Psoriatic Arthritis)

Incidence of lymphoma associated with underlying lupus (SLE): Lessons learned from observational studies. Although the association of non-Hodgkin's lymphoma in SLE is well established, risk factors attributing to this association are still not understood. PubMed, Curr Opin Rheumatol, 2014 Mar;26(2):111-7. (Also see Systemic Lupus Erythematosus Symptoms and Non Hodgkin's Lymphoma)

T cell repertoire (TCR) following autologous stem cell transplantation for multiple sclerosis. TCR characterization during immunomodulatory treatment is both feasible and informative, and may enable monitoring of pathogenic or protective T cell clones following HSCT and cellular therapies. PubMed, J Clin Invest, 2014 Feb 17. (Also see Multiple Sclerosis and Stem Cell Transplantation)

Gender differences in multiple sclerosis (MS): induction of estrogen signaling in male and progesterone signaling in female lesions. The different gender-specific responses in steroid synthesis and signaling in the brains of multiple sclerosis (MS) patients may represent contributing factors to gender differences in the prevalence and course of MS. PubMed, J Neuropathol Exp Neurol, 2014 Feb;73(2):123-35. (Also see Multiple Sclerosis)

Fibromyalgia and chronic widespread pain in autoimmune thyroid disease. This review looks at the current understanding of the prevalence of pain syndromes in autoimmune thyroid disease, their likely causes, present appreciation of the pathogenesis of chronic widespread pain, and how our knowledge can be used to find lasting and effective treatments for the pain syndromes associated with autoimmune thyroid disease. PubMed, Clin Rheumatol, 2014 Jan 18. (Also see Fibromyalgia and Autoimmune Thyroid Disease)

Fibromyalgia in patients with axial spondyloarthritis: epidemiological profile and effect on measures of disease activity. Findings suggest that the Ankylosing Spondylitis Disease Activity Score ( ASDAS) is better than the Bath Ankylosing Spondylitis Activity Disease Activity Index (BASDAI) in distinguishing patients with disease activity and the use of ASDAS may be very useful in clinical practice as it allows treating patients with the most appropriate therapy. PubMed, Rheumatol Int, 2014 Feb 8. (Also see Fibromyalgia)

Go to Autoimmune News: February 2014
 
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