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July 2014 Autoimmune News

Immune responses to stress in rheumatoid arthritis (RA) and psoriasis. Patients with RA have a different immune response to stress than patients with psoriasis or healthy controls. More needs to be learned about the complex interaction between stress, immune parameters and chronic inflammation. PubMed, Rheumatology (Oxford), 2014 May 20. (Also see Rheumatoid Arthritis, Psoriasis, and Stress)

Depression, anxiety, and quality of life in a large cohort of patients with rheumatic diseases: common, yet undertreated. For the management of depression and anxiety, an increased awareness among physicians dealing with rheumatologic patients is warranted in order to integrate detection and effective treatment of anxiety and depression into the routine clinical practice. PubMed, Clin Rheumatol, 2014 May 25. (Also see Depression and Rheumatic Diseases)

Identification of lymphoma predictors in patients with primary Sjögren's syndrome: a systematic literature review and meta-analysis. Patients with primary Sjögren syndrome have an increased risk of lymphoma or lymphoproliferative disease compared to the general population and ascertaining relevant and reliable predictors would greatly facilitate the identification of patients at elevated risk for closer monitoring. PubMed, Rheumatol Int, 2014 Jun 5. (Also see Sjogren's Syndrome)

Implication of Epstein-Barr virus (EBV) infection in disease-specific autoreactive B cell activation in ectopic lymphoid structures of Sjogren's syndrome (SS). Active EBV infection is selectively associated with ectopic lymphoid structures in salivary glands of Sjogren's syndrome and appears to contribute to local growth and differentiation of disease-specific autoreactive B-cells. PubMed, Arthritis Rheumatol, 2014 May 28. (Also see Sjogren's Syndrome and B Cells and T Cells)

The association of cytokines with disease activity and damage scores in systemic lupus erythematosus (SLE) patients. Increased levels of a number of immunomodulatory cytokines relative to IL-12p70 in this Caucasian SLE patient population are seen in patients with renal involvement and are associated with increased accrual of damage at the 5-year follow-up. PubMed, Rheumatology (Oxford), 2014 Apr 4. (Also see Systemic Lupus Erythematosus Symptoms: Kidneys)

High prolactin levels are independently associated with damage accrual in systemic lupus erythematosus patients. There was a positive association between prolactin levels and the damage index (SDI) (overall and its renal and cardiac/peripheral vascular domains), independently of other well-known risk factors. PubMed, Lupus, 2014 Apr 9. (Also see Systemic Lupus Erythematosus)

Glucocorticoids and irreversible damage in patients with systemic lupus erythematosus (SLE). Prednisone causes damage in SLE, but doses less than 7.5 mg/day and methylprednisolone pulses are not associated with damage accrual. PubMed, Rheumatology (Oxford), 2014 Mar 27. (Also see Systemic Lupus Erythematosus and Glucocorticoids, Steroids (Prednisone) Warnings)

Impaired endothelial function in patients with undifferentiated connective tissue disease (UCTD): a follow-up study. The data suggest that the presence of inflammation and autoantibodies provoke endothelial cell activation and/or injury in UCTD patients. PubMed, Rheumatology (Oxford), 2014 Jun 10. (Also see Undifferentiated Connective Tissue Disease)

Perioperative management of antiphospholipid antibody(aPL)-positive patients. There are limited data on which to base recommendations and periods without anticoagulation should be kept to an absolute minimum for patients with a history of thrombosis. PubMed, Curr Rheumatol Rep, 2014 Jul;16(7):426. (Also see Antiphospholid Syndrome)

The effect of rituximab therapy on immunoglobulin levels in patients with multisystem autoimmune disease. In multi-system autoimmune disease, prior cyclophosphamide exposure and glucocorticoid therapy but not cumulative rituximab dose was associated with an increased incidence of hypogammaglobulinaemia and repeat dose rituximab therapy appears safe with judicious monitoring. PubMed, BMC Musculoskelet Disord, 2014 May 25;15(1):178. (Also see Mainstream Treatments: Biologics)

Go to Autoimmune News: June 2014
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