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May 2015 Autoimmune News

Clinical characteristics and survival in idiopathic pulmonary fibrosis (IPF) and connective tissue disease-associated usual interstitial pneumonia (CTD-UIP). Although the survival of CTD-UIP patients was similar compared with that of IPF/UIP patients, it appears that Undifferentiated Connective Tissue Disease influences the survival rate of CTD-UIP patients. Journal of Thoracic Disease, 04/03/2015. (Also see Connective Tissue Disease and Pulmonary Fibrosis Prognosis)

Salivary mucins induce a Toll-like receptor 4 (TLR4)-mediated pro-inflammatory response in human submandibular salivary cells: are mucins involved in Sjögren's syndrome (SS)? Salivary mucins were recognized by TLR4 in epithelial cells initiating a pro-inflammatory response and thereby contribute to the development of a chronic state characteristic of SS. PubMed, Rheumatology (Oxford), 03/22/2015. (Also see Sjogren's Syndrome Research)

Effect of mycophenolate mofetil on the white blood cell count and the frequency of infection in systemic lupus erythematosus. Leukopenia does not worsen with mycophenolate mofetil, which appears to slightly increase the rate of bacterial (but not viral) infection. PubMed, Rheumatol Int, 04/03/2015. (Also see Treatments for Lupus)

Significant bone microarchitecture impairment in premenopausal women with active celiac disease (CD). Patients with symptomatic CD had a greater bone microarchitectural deficit than those with subclinical CD. Bone, 03/14/2015. (Also see Osteoporosis and Celiac Disease)

Impact of treatment with inhaled corticosteroids (ICS) on bone mineral density (BMD) of patients with asthma: related with age. This study indicates that BMD reduction in ICS users with asthma is dependent on age and appears that younger patients are at greater risk of BMD loss. PubMed, Osteoporos Int, 04/10/2015. (Also see Asthma Treatments and Osteoporosis)

The effect of tofacitinib on pneumococcal and influenza vaccine responses in rheumatoid arthritis. Among existing tofacitinib users, temporary drug discontinuation had limited effect upon influenza or 23-valent pneumococcal polysaccharide vaccine responses. PubMed, Ann Rheum Dis, 03/20/2015. (Also see Treatments for Rheumatoid Arthritis)

Vascular calcifications on hand radiographs in rheumatoid arthritis (RA) and associations with autoantibodies, cardiovascular risk factors and mortality. Vascular calcifications on hand radiographs were independently associated with increased all-cause mortality in RA. PubMed, Rheumatology (Oxford), 04/07/2015. (Also see Symptoms and Complications of Rheumatoid Arthritis)

Bone health in type 1 diabetes (T1D): focus on evaluation and treatment in clinical practice. The improvement of glycemic control has been suggested to have a beneficial effect on bone in T1D. PubMed, J Endocrinol Invest, 04/12/2015. (Also see Symptoms and Complications of Diabetes)

Pain characteristics in fibromyalgia: understanding the multiple dimensions of pain. The reciprocal effects of mood and fatigue on pain experience could be identified; catastrophizing scores show a high correlation with overall life quality and pain experience. PubMed, Clin Rheumatol, 2015 Apr;34(4):775-83. (Also see Fibromyalgia)

Obesity and sleepiness in women with fibromyalgia (FM). There is an important association between sleepiness and FM, suggesting that the occurrence of obesity may be involved with sleepiness in these patients. PubMed, Rheumatol Int, 2015 Feb;35(2):281-7. (Also see Fibromyalgia)

Go to Autoimmune News: April 2015
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