Biomarkers in rheumatic diseases: how can they facilitate diagnosis and assessment of disease activity? The ultimate goal of current and future biomarkers in rheumatic diseases is to enable early detection of these diseases and their clinical manifestations. PubMed, BMJ, 2015 Nov 26;351:h5079. (Also see Biomarkers)
Nailfold capillaroscopic findings in primary Sjögren's syndrome with and without Raynaud's phenomenon and/or positive anti-SSA/Ro and anti-SSB/La antibodies. Patients with RP associated with PSS had more dilated capillaries, but neither pericapillary haemorrhages nor capillary thrombosis was observed. PubMed, Rheumatol Int, 11/23/2015. (Also see Diagnosis of Primary Raynaud's using Nailfold Capillaroscopy and Diagnosis of Sjogren's Syndrome)
Antiphospholipid antibodies in patients with upper-extremity deep vein thrombosis (UEDVT). UEDVT could be the first clinical symptom of Antiphospholipid syndrome, and may be the first clinical manifestation of preceding the development of Systemic Lupus Erythematosus by several years. PubMed, Cent Eur J Immunol, 2015;40(3):307–310. (Also see Antiphospholipid Syndrome and Antibodies in Lupus)
Disturbed T Cell Signaling and Altered Th17 and Regulatory T Cell Subsets in the Pathogenesis of Systemic Lupus Erythematosus. In patients with SLE increased numbers of autoreactive Th17 cells have been documented, and Th17 cells appear to be responsible for tissue inflammation and damage. PubMed, Front Immunol, 2015 Nov 30;6:610. (Also see B Cells and T Cells)
Transplantation of mesenchymal stem cells (MSCs) improves type 1 diabetes mellitus. Intrapancreatic transplantation of MSCs triggers a series of molecular and cellular events, including differentiation towards the pancreas directly and the provision of a niche to start endogenous pancreatic regeneration. PubMed, Cell Tissue Res, 12/09/2015. (Also see Treatments for Diabetes)
Rheumatoid Arthritis: Notable Biomarkers Linking to Chronic Systemic Conditions and Cancer. Due to the complex nature of the disease, the appearance of symptoms and markers vary amongst individuals and the connections may manifest only in part. PubMed, Curr Pharm Des, 12/09/2015. (Also see Diagnosis of Rheumatoid Arthritis and Cancer)
Systemic Lupus Erythematosus (SLE): Another Autoimmune Disorder Influenced by Microbes and Diet? In this review, the aim is to compile the available evidence on the contributions of diet and gut microbes to SLE occurrence and pathogenesis. PubMed, Front Immunol, 2015 Nov 30;6:608. (Also see Causes of Lupus)
Pancreas Islet Transplantation for Patients With Type 1 Diabetes Mellitus: A Clinical Evidence Review. For patients with type 1 diabetes with difficult-to-control blood glucose levels, islet transplantation may be a beneficial ß-cell replacement therapy to improve glycemic control and secondary complications of diabetes. PubMed, Ont Health Technol Assess Ser, 2015 Sep 1;15(16):1-84. (Also see Treatments for Diabetes)
Prevalence of Psoriatic Arthritis in Primary Care Patients with Psoriasis. Among psoriasis patients in primary care the prevalence of PsA is conservatively estimated to be 3.2% increasing to 4.6% if enthesitis is taken into account. PubMed, Arthritis Rheumatol, 12/04/2015. (Also see Psoriasis and Psoriatic Arthritis)
Fear of Falling in Women with Fibromyalgia (FM) and Its Relation with Number of Falls and Balance Performance. FM has an impact on fear of falling, balance performance, and number of falls. Perceived balance problems seem to be more closely associated with fear of falling than objective balance performance. PubMed, Biomed Res Int, 2015;2015:589014. (Also see Fibromyalgia)
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