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February 2016 Autoimmune News

Arterial stiffness (AS) is associated with left ventricular (LV) dysfunction in patients with rheumatoid arthritis (RA). The aim of the study was to evaluate the impact of AS on LV functions in patients with rheumatoid arthritis. Springer Link, 01/07/2016. (Also see Symptoms and Complications of Rheumatoid Arthritis)

The Obesity Epidemic and Consequences for Rheumatoid Arthritis Care. Obesity has been observed to be associated with greater subjective measures of disease activity and poor treatment response, and also with a decreased risk of joint damage and lower mortality. Springer Link, 01/07/2016. (Also see Rheumatoid Arthritis)

Elucidation of the potential disease-promoting influence of IgM apoptotic cell–reactive antibodies in lupus. Apoptotic cell-reactive IgM antibodies may be potentially capable of influencing the course of systemic autoimmune disease by affecting both innate and adaptive immunity. Lupus, 01/06/2016. (Also see Autoantibodies)

High-density lipoprotein (HDL) function in rheumatoid arthritis. Additional studies will be valuable to consolidate existing data and find consensus and also studies evaluating the impact of various HDL functions on cardiovascular disease in RA are needed. PubMed, Curr Opin Lipidol, 2016 Feb;27(1):67-75. (Also see Causes of Rheumatoid Arthritis)

Homocysteine (HHcy) serum levels are increased and correlate with disease severity in patients with lupus erythematosus (LE). Hcy levels were higher in patients with different forms of cutaneous LE and correlated with disease activity, therefore HHcy could be related to LE pathogenesis and might be a triggering factor in predisposed individuals. PubMed, Clin Exp Rheumatol, 01/08/2016. (Also see Causes of Lupus)

Group for research and assessment of psoriasis and psoriatic arthritis (PsA): Treatment recommendations for psoriatic arthritis 2015. Overarching principles and updated treatment recommendations for the key manifestations of PsA, including related comorbidities are presented and further updates are anticipated as the therapeutic landscape in PsA evolves. Wiley Online Library, 01/11/2016. (Also see Psoriasis and Psoriatic Arthritis)

Predictors of clinical outcomes in patients with neuropsychiatric systemic lupus erythematosus (NPSLE). Patients with longer disease durations of SLE and those with more than one NPSLE symptom types had poorer outcomes. ScienceDirect, 01/07/2016. (Also see Symptoms and Complications of Lupus)

IL-8 and IL-6 primarily mediate the inflammatory response in fibromyalgia (FM) patients. These findings indicate that IL-6 and IL-8 are two of the most constant inflammatory mediators in FM and that their levels correlate significantly with the severity of symptoms. PubMed, J Neuroimmunol, 2016 Jan 15;290:22-5. (Also see Interleukins)

Characterizing the phenotype of multiple sclerosis (MS)–associated depression in comparison with idiopathic major depression. The clinical phenotype of “idiopathic” major depressive disorder and MS–associated depression appears similar when adequately examined. PubMed, Mult Scler, 01/08/2016. (Also see Multiple Sclerosis and Depression)

A randomised, double-blinded study comparing giving etoricoxib vs. placebo to female patients with fibromyalgia. Although being mildly underpowered this study clearly has shown that etoricoxib did not improve pain scores and did not lead to any beneficial mental or physical effects. PubMed, Int J Clin Pract, 01/13/2016. (Also see Fibromyalgia)

Go to Autoimmune News: January 2016
 
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