Scleroderma Medical News by Date |
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| February 2010 | |
| Exercise in systemic sclerosis intensifies systemic inflammation and oxidative stress. Although exercise capacity is impaired in patients with SSc, physical activity intensifies the already increased basal levels of systemic inflammation and oxidative stress. These data support the concept of a role for systemic inflammation and oxidative stress in the ongoing systemic effects of SSc. H Harðardóttir. (PubMed) Scand J Rheumatol. 2010;39(1):63-70. (Also see: Oxidative Stress) | |
| Vascular Inflammation in Obesity and Sleep Apnea. Untreated obstructive sleep apnea rather than obesity is a major determinant of vascular endothelial dysfunction, inflammation, and elevated oxidative stress in obese patients. Sanja Jelic MD. Circulation. February 16, 2010 (Also see: Sleep Apnea and Oxidative Stress) | |
| Sensitivity to Change in Systemic Sclerosis (SSc) of the McMaster-Toronto Arthritis Patient Preference Disability Questionnaire (MACTAR): Shift in Patient Priorities Over Time. The evolution in MACTAR global score over time for patients with SSc reflects longterm general feelings of deterioration. However, shifts in patient priorities are common and may influence the sensitivity to change of the instrument. Christelle Nguyen. J Rheum. Jan. 15, 2010. (Also see: Quality of Life) | |
| Pulmonary arterial hypertension (PAH) associated with systemic sclerosis (SSc) in patients with functional class II dyspnoea: mild symptoms but severe outcome. A majority of patients with mildly symptomatic SSc-PAH in New York Heart Association (NYHA) functional class (FC) II at diagnosis have a severe disease with poor prognosis. Eric Hachulla. Rheumatology. February 8, 2010. (Also see: Pulmonary Hypertension: Prognosis) | |
| Researchers revisit pulmonary arterial hypertension survival. Setting out to determine the survival of patients with pulmonary arterial hypertension (PAH), researchers at the University of Chicago Medical Center and their colleagues also discovered that an equation used for more than 20 years to predict survival is outdated. University of Chicago Medical Center. 01/06/10. (Also see: Pulmonary Hypertension: Prognosis) | |
| Heart rate turbulence (HRT) assessment in systemic sclerosis (SSc): the role for the detection of cardiac autonomic nervous system dysfunction. HRT, like time- and frequency-domain heart rate variability (HRV) assessment, indicates a frequent impairment of the cardiac autonomic nervous system in SSc patients, irrespective of the SSc type. Piotr Bienias. Rheumatology. December 9, 2009. (Also see: Heart Involvement) | |
| Low influenza vaccination rate among patients with systemic sclerosis. Influenza vaccination coverage is low in SSc patients. Lack of information and fear of adverse effects are the most common reasons for non-vaccination. Efforts are needed to increase the influenza vaccination coverage in this population. Luc Mouthon. Rheumatology. December 29, 2009. (Also see: Vaccinations) | |
| Gastric Antral Vascular Ectasia (GAVE) in Systemic Sclerosis (SSc): Demographics and Disease Predictors. Diffuse cutaneous SSc (dcSSc) is associated with earlier development of GAVE, as well as more severe anemia requiring more therapeutic interventions. Rapid progression of cutaneous disease may suggest earlier development of GAVE. Absence of antitopoisomerase I antibodies and presence of antibodies to RNAP III/speckled antinuclear antibody pattern may be useful to identify the subset of patients with SSc with increased risk for GAVE. Kristin M. Ingraham. J Rheum. Jan. 21, 2010. (Also see: GAVE) | |
| Malignancy in scleroderma patients from south west England: a population-based cohort study. in this small patient cohort, we have found that scleroderma is associated with an increased risk of malignancy. This risk is statistically significant in patients with limited scleroderma. Patients who are elderly and those with limited disease should be closely scrutinized at follow-up appointments. Keith Siau. Rheumatology International (SpringerLink). January 07, 2010. (Also see: Cancer and Scleroderma) | |
| Occupational silica exposure as a risk factor for scleroderma: a meta-analysis. The findings suggest that silica exposure may be a significant risk factor for developing SSc and specifically in males. Further observational studies examining the role of occupational silica exposure in the context of other risk factors are needed. Zachary D. McCormic. (SpringerLink) International Archives of Occupational and Environmental Health. 01/02/10. (Also see: Causes of Scleroderma - Silica) | |
| Anti-RNA Polymerase III Antibody Prevalence and Associated Clinical Manifestations in a Large Series of French Patients with Systemic Sclerosis (SSc): A Cross-sectional Study. The prevalence of anti-RNA polymerase III antibodies in French patients appeared to be lower than in the United States and similar to that in continental Europe. These antibodies were consistently associated with diffuse cutaneous disease and were the most common immunological marker for renal crisis. Anti-RNA polymerase III determination can help to risk-stratify SSc patients at high risk for this severe manifestation. Olivier Meyer.J. Rheum. Nov 16, 2009 (Also see: RNA-Polymerases Antibodies and Geographic Regions) | |
| Rheumatic diseases: Environment and genetics. Genetic studies have established that a common genetic background is shared by many autoimmune disorders. Interestingly, although common genetic factors are shared by diseases that produce different phenotypes, risk variants can exert a strong influence on the phenotype of a given disease. P. Dieudé . Joint Bone Spine. 2009 Nov 16. (Also see: Environment and Genetics) |
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