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October 2013 Scleroderma News

Actelionís Opsumit Approved by FDA for Pulmonary Arterial Hypertension. The FDA has approved the use of Opsumit (Macitentan) for treatment of pulmonary arterial hypertension (PAH). The Guardian. 10/20/2013. (Also see Opsumit/Macitentan)

Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma (SSc). Researchers have developed a mouse model of Scleroderma and their studies are pointing the way to potential new drug therapies for the disease. Nature. 10/09/2013. (Also see Scleroderma Research)

Preliminary analysis of the Very Early Diagnosis of Systemic Sclerosis (SSc) (VEDOSS) EUSTAR multicentre study: evidence for puffy fingers (PuFi) as a pivotal sign for suspicion of systemic sclerosis. PuFi is an important sign raising suspicion for underlying very early SSc in patients with RP. Ann Rheum Dis, 08/12/2013. (Also see Diagnosis of Scleroderma)

Pathogenesis and therapeutics of interstitial lung disease in systemic sclerosis. For patients who are unresponsive to pharmacologic interventions, data is presented regarding the efficacy of highdose immunosuppression with autologous transplantation of hematopoietic stem cells, and lung transplantation. Current Rheumatology Reviews, 08/10/2013. (Also see Pulmonary Fibrosis Treatments)

Systemic sclerosis (SSc) sera affect fibrillin-1 deposition by dermal blood microvascular endothelial cells: therapeutic implications of cyclophosphamide (CYC). In SSc, CYC treatment might limit fibrosis through the maintenance of physiological fibrillin-1 synthesis and deposition by B-MVECs. PubMed, Arthritis Res Ther, 2013 Aug 20. (Also see Cyclophosphamide

Recognizing and treating myocarditis in recent-onset systemic sclerosis heart disease. Myocarditis is a common finding in systemic sclerosis (SSc) patients with recent-onset cardiac involvement. PubMed, Semin Arthritis Rheum. 08/06/2013. (Also see Cardiac Involvement)

Survival remains poor for systemic sclerosis-associated pulmonary hypertension. Despite the frequent assertion that survival has improved in recent years for patients who have pulmonary hypertension associated with systemic sclerosis, a meta-analysis that allowed pooling of data from numerous small studies shows otherwise. Rheumatology News, 09/05/2013. (Also see Pulmonary Hypertension Prognosis)

Screening and diagnostic modalities for connective tissue disease-associated pulmonary arterial hypertension (PAH). Our systematic review revealed that most evidence exists for transthoracic echocardiogram (TTE), pulmonary function tests, and NT-ProBNP for screening and diagnosis of systemic sclerosis-PAH; however, more robust studies are needed. PubMed, Semin Arthritis Rheum, 2013 Sep 5. (Also see Pulmonary Hypertension Diagnosis)

Frequency of development of connective tissue disease (CTD) in statin-users versus nonusers. Statins have pleiotropic properties that may affect the development of (CTD). Statin use was associated with a lower risk of CTD. PubMed, Am J Cardiol, 09/15/2013. (Also see Connective Tissue Disease and Statins)

Cutaneous Chronic Graft-Versus-Host Disease. Cutaneous involvement is the most frequent manifestation of chronic graft-versus-host disease (cGVHD). Wiley Online Library, 09/06/2013. (Also see Graft-Versus-Host Disease)

Scleroderma patients suffer from small bowel bacterial overgrowth. More than a third of patients with systemic sclerosis and intestinal symptoms have an increase in gastrointestinal tract bacteria, an alteration in the type of gut microbes present, or both. Rheumatology News, 07/02/2013. (Also see Intestinal Bacterial Overgrowth)

Go to Scleroderma Medical News: September 2013
 
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