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November 2013 Scleroderma News

Psychosocial aspects of systemic sclerosis(SSc). To better address the psychosocial needs of persons with SSc, interventions need to be developed and tested. PubMed, Curr Opin Rheumatol, 2013 Nov;25(6):707-13. (Also see Emotional Adjustment and Scleroderma)

Preclinical and translational research to discover potentially effective antifibrotic therapies in systemic sclerosis (SSc). There is a high unmet clinical need for effective antifibrotic therapies in systemic sclerosis (SSc), and in parallel a rapid development in the identification of potential molecular targets in preclinical research. This could increase the possibility to develop successful drugs against the fibrotic manifestations of SSc. PubMed, Curr Opin Rheumatol, 2013 Nov;25(6):679-85. (Also see What is Fibrosis? and Scleroderma Clinical Trials)

Abnormal cardiac enzymes in systemic sclerosis. Cardiac biomarkers such as troponin T (TnT) may be useful screening tools to identify subclinical cardiac disease and assess response to therapeutic intervention. Clinical Rheumatology, October 2013. (Also see Cardiac (Heart) Involvement and Biomarkers)

Stem cell transplantation in systemic sclerosis. Stem cell transplantation is an effective treatment option for patients with severe systemic sclerosis, but is associated with toxicity and treatment-related mortality. Patient selection and comprehensive cardiopulmonary screening are critical factors in determining outcome. PubMed, Curr Opin Rheumatol, 2013 Nov;25(6):719-25. (Also see Stem Cell Transplantation)

The differential diagnosis of systemic sclerosis. Skin thickening is a nonspecific manifestation of many different processes including (rarely) early scleroderma, which is mostly symmetrical and associated with Raynaud's phenomenon, nailfold capillaroscopic changes and antinuclear antibodies. PubMed, Curr Opin Rheumatol, 2013 Nov;25(6):692-9. (Also see Difficult Diagnosis)

Lung transplantation in patients with scleroderma. Lung transplantation represents a viable therapeutic option to consider for patients with end-stage lung disease due to systemic sclerosis (SSc) who have limited extrapulmonary manifestations. PubMed, Curr Opin Rheumatol, 2013 Nov;25(6):714-8. (Also see Pulmonary Fibrosis Treatments: Lung Transplants)

Measuring response in the gastrointestinal tract (GIT) in systemic sclerosis. Recommendations are given for trial design and evaluation of GIT involvement in SSc. PubMed, Curr Opin Rheumatol, 2013 Nov;25(6):700-6. (Also see Gastrointestinal Involvement)

Hair miR-29a levels are decreased in patients with scleroderma. We found scleroderma patients with decreased miR-29a levels had contracture of the phalanges at a significantly higher prevalence than those without. To confirm the clinical usefulness of hair microRNAs, large-scale researches are needed in the future. Experimental Dermatology.

Short And Long Term Outcome Of Linear Morphea (LM) In Children. Despite a wide range of therapeutics reported in LM, there is currently a lack of consensus on the optimal therapy. LM needs prolonged monitoring as the disease could have very long periods of quiescence followed by reactivation. PubMed, Br J Dermatol, 2013 Sep 6. (Also see Localized Scleroderma)

Classification Criteria for Systemic Sclerosis. The ACR/EULAR classification criteria for systemic sclerosis (SSc) performed better than the 1980 ACR criteria and should allow for more patients to be classified correctly as having the disease. Arthritis & Rheumatism, 3 October 2013. (Also see Systemic Scleroderma)

Go to Scleroderma Medical News: October 2013
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