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December 2013 Scleroderma News

Association of the Autoimmune Disease Scleroderma with an Immunologic Response to Cancer. This offers an insight into the pathogenesis of scleroderma and provide support for the idea that acquired immunity helps control naturally occurring cancers. Science Express 12/05/2013 (Also see Cancer and Scleroderma)

What does global gene expression profiling tell us about the pathogenesis of systemic sclerosis? Global gene expression profiling in skin and peripheral blood can contribute to a better understanding of SSc pathogenesis and identify novel biomarkers and therapeutic targets. PubMed, Curr Opin Rheumatol, 2013 Nov;25(6):686-91. (Also see Skin Fibrosis)

Histological features of localized scleroderma 'en coup de sabre': a study of 16 cases. The elimination of mutated epidermal cells by immune surveillance contributes to tissue damage and resultant fibrosis in localized scleroderma. PubMed, J Eur Acad Dermatol Venereol, 2013 Oct 10. (Also see En Coup De Sabre)

New developments in juvenile systemic (jSS) and localized scleroderma (jLS). The new classifications, developments, and adaptations of the outcome measures for certain organ involvements whereby progress has been made regarding pediatric patients. PubMed, Rheum Dis Clin North Am, 2013 Nov;39(4):905-20. (Also see Juvenile Scleroderma)

Survival in systemic sclerosis(SSc)-associated pulmonary arterial hypertension (PAH) in the modern management era. SSc-associated PAH remains a devastating disease and age, male gender, and cardiac index were the main prognosis factors. Early detection of less severe patients should be a priority. PubMed, Ann Rheum Dis, 2013 Dec 1;72(12):1940-6. (Also see Pulmonary Hypertension Prognosis)

Left Ventricular Ejection Time (LVET) in Acute Heart Failure Complicating Precapillary Pulmonary Hypertension. Shortened LVET at ICU admission was a prognostic factor in patients with precapillary PH with heart failure. Chest, 2013;144(5):1512-1520. (Also see Pulmonary Hypertension Prognosis)

Pulmonary Fibrosis Preceding Skin Involvement in Scleroderma. Pulmonary fibrosis can be the initial manifestation of scleroderma, preceding skin involvement. Chest, 2013;14. (Also see Pulmonary Fibrosis)

Combined Pulmonary Fibrosis and Emphysema (CPFE) Among Patients With Scleroderma (SSc)-Associated Pulmonary Hypertension (PH). There appears to be no difference in the severity of PH or in pulmonary function between SSc-PH patients with and without CPFE. Chest, 2013;144. (Also see Pulmonary Fibrosis and Pulmonary Hypertension)

Is immunosuppressive therapy the anchor treatment to achieve remission in systemic sclerosis (SSc)? Patients with rapidly progressing diffuse cutaneous SSc should be evaluated for hematopoietic stem cell transplantation. PubMed, Rheumatology, 2013 Oct 31. (Also see Immunosuppressants, and Stem Cell Transplantation)

Scleroderma-related lung disease: are adipokines involved pathogenically? The systemic nature of scleroderma-related lung disease has led many to implicate circulating factors in the pathogenesis of some of its organ impairment. PubMed, Curr Rheumatol Rep, 2013 Dec;15(12):381. (Also see Pulmonary Fibrosis Research, and Causes of Scleroderma: Cytokines)

Go to Scleroderma Medical News: November 2013
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