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April 2014 Scleroderma News

PatientCrossroads and Lipodystrophy United Launch Global Registry for Lipodystrophy. No one knows exactly how many people are affected by lipodystrophy worldwide, and clinical endpoints that could gauge the effectiveness of treatments are sparse. PR Web, 03/04/2014. (Also see Lipodystrophy)

Fracture Risk High in Systemic Sclerosis. Among the myriad potentially debilitating complications faced by patients with systemic sclerosis is an increased risk of osteoporotic fractures. Med Page Today, 02/19/2014. (Also see Osteoporosis in Scleroderma)

Prediction of pulmonary complications and long term survival in systemic sclerosis (SSc). This study provides data on long-term outcome of SSc and the timing and frequency of major organ complications. PubMed, Arthritis Rheumatol, 03/03/2014. (Also see Prognosis of Pulmonary Hypertension and Pulmonary Involvement)

Assessment of skin microcirculation by laser Doppler flowmetry (LDF) in systemic sclerosis patients (SSc). LDF is suitable for the assessment of the microangiopathy degree in SSc patients. Ter Media, Postep Derm Alergol, 03/05/2014. (Also see Skin Fibrosis)

Frailty Index (FI) to Measure Health Status in People with Systemic Sclerosis. The FI quantifies overall health status in people with scleroderma and predicts mortality and it might help with decisions about who might best be served by more aggressive treatment, such as bone marrow transplantation. PubMed, J Rheumatol, 03/01/2014. (Also see Systemic Scleroderma: Prognosis and Mortality)

Caveolin-1 deficiency predisposes African-Americans to systemic sclerosis-interstitial lung disease (SSc-ILD). African-Americans may be predisposed to SSc-ILD due to low baseline caveolin-1 levels in their monocytes. PubMed, Arthritis Rheumatol, 02/27/2014. (Also see Causes of Scleroderma: Race/Ethnicity)

The association of antiphospholipid antibodies (APLA) with cardiopulmonary manifestations of systemic sclerosis. APLA is associated with pulmonary arterial hypertension (PH), interstitial lung disease, Raynaud's phenomenon and digital ulcers, so endothelial abnormalities and small vessel thrombosis may be important in the pathogenesis of these disease features. PubMed, Clin Exp Rheumatol, 2014 Feb 24. (Also see Antiphospholipid Syndrome, Causes of Pulmonary Hypertension , Raynaud's and Digital Ulcers)

Ultrasound (US) in systemic sclerosis (SSc). A multi-target approach from joint to lung. Discussion of the current evidence supporting ultrasound relevance and applications in daily clinical practice. PubMed, Clin Rheumatol, 02/18/2014. (Also see Pulmonary Fibrosis Diagnosis)

Angiotensin receptor type 1 (AT1R) and endothelin receptor type A (ETAR) on immune cells mediate migration and the expression of IL-8 and CCL18 when stimulated by autoantibodies from systemic sclerosis (SSc) patients. PubMed, Arthritis Res Ther, 2014 Mar 11;16(2):R65. (Also see Antibodies in Systemic Scleroderma and Causes of Scleroderma: Endothelin)

Development of pulmonary hypertension (PH) in a high risk population with systemic sclerosis in the Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma (PHAROS) cohort study. A low DLco, high FVC/DLco, exercise-induced hypoxia and entry echo sPAP arrow 40 were strongly associated with future PH. Seminars in Arthritis and Rheumatism, 03/07/2014. (Also see Pulmonary Hypertension Diagnosis, and PHAROS)

Go to Scleroderma Medical News: March 2014
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