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August 2014 Scleroderma News

Autologous Hematopoietic Stem Cell Transplantation (HSCT) vs Intravenous Pulse Cyclophosphamide in Diffuse Cutaneous Systemic Sclerosis: A Randomized Clinical Trial. Among patients with early diffuse cutaneous systemic sclerosis, HSCT was associated with increased treatment-related mortality in the first year after treatment. However, HCST conferred a significant long-term event-free survival benefit. JAMA, 2014;311(24):2490-2498. (Also see Stem Cell Transplantation and Cyclophosphamide Research)

Arterial vasculopathy in systemic sclerosis (SSc): Computerized tomography (CT) angiographic features of macrovascular and microvascular upper limbs arteries. Macrovascular arterial vasculopathy of upper limbs may occur in SSc irrespective of the disease pattern and major arteries can be affected in association with other medium sized arteries of the forearms and microvascular arterial branches of the hands. PubMed, Joint Bone Spine, 2014 Jun 20. (Also see Vascular Involvement)

Effect of menopause on the modified Rodnan skin score (mRSS) in systemic sclerosis (SSc). Results suggest that menopause has a substantial effect on skin thickening in diffuse SSc, with postmenopausal status being associated with a lower mean mRSS compared to premenopausal status. PubMed, Arthritis Res Ther, 2014 Jun 23;16(3):R130. (Also see Skin Fibrosis)

Evidence-based detection of pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc): the DETECT study. The novel, evidence-based DETECT algorithm for PAH detection in SSc is a sensitive, non-invasive tool which minimises missed diagnoses, identifies milder disease and addresses resource usage. PubMed, Ann Rheum Dis, 2014 Jul;73(7):1340-9. (Also see Pulmonary Hypertension)

Involvement of CD161+ Vδ1+ yδ T cells in systemic sclerosis (SSc): association with interstitial pneumonia (IP). The small proportion and the altered cell functions of CD161+ Vδ1+ yδ T cells among peripheral blood mononuclear cells in SSc patients play a role in the pathogenesis of IP and may play a regulatory role in pathogenesis. PubMed, Rheumatology (Oxford), 2014 Jun 27. (Also see B and T Cells and Systemic Sclerosis)

Clinical and laboratory features of overlap syndromes (OS) of idiopathic inflammatory myopathies associated with systemic lupus erythematosus, systemic sclerosis, or rheumatoid arthritis. This is the first study to show the different characteristics of a series of patients with connective tissue disease (CTD)-OS in the heterogeneous Brazilian population. PubMed, Clin Rheumatol, 2014 Jul 4. (Also see Systemic Sclerosis in Overlap)

The global peripheral chemoreflex drive (GPCD) in patients with systemic sclerosis (SSc): a rebreathing and exercise study. The GPCD was diminished in dcSSc patients, suggesting an altered control of breathing and its assessment may help the clinician to better understand reported exercise intolerance and exertional dyspnea in dcSSc patients. PubMed, QJM, 2014 Jul 13. (Also see Lung Involvement)

A cross-sectional electromyography (EMG) assessment in linear scleroderma (LS) patients. In a small series of LS patients, there was a surprising amount of muscle dysfunction by EMG. The muscle involvement may be possibly related to a secondary peripheral nerve involvement due to LS inflammation and fibrosis. PubMed, Pediatr Rheumatol Online J, 2014 Jul 12;12:27. (Also see Linear Scleroderma)

Systemic Sclerosis (SSc) and the Risk of Tuberculosis (TB). In this nationwide study, the incidence of TB infection was significantly higher among patients with SSc than in controls without SSc and special care should be taken in managing patients with SSc who are at high risk for TB. PubMed, J Rheumatol, 2014 Jul 15. (Also see Tuberculosis and Scleroderma)

(Case Report) Coexistence of Ankylosing Spondylitis (AS) With Morphea. Morphea and AS with an inflammatory background and active immunity can exist in the same patient and recent studies have showed the importance of Th17 and associated cytokines in the pathogenesis of these two diseases. Archives of Rheumatology 2014, Volume 29, Number 2, P 143-146. (Also see Morphea, Ankylosing Spondylitis, and Causes of Scleroderma: Cytokines)

Go to Scleroderma Medical News: July 2014
 
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