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September 2014 Scleroderma News

Good outcome of interstitial lung disease in patients with scleroderma associated to anti-PM/Scl antibody. Several features and prognosis of ILD in SSc may be modified depending on the identified immunological profile. Seminars in Arthritis and Rheumatism, 07/15/2014. (Also see Pulmonary Fibrosis Prognosis and Antibodies in Systemic Scleroderma)

Incidence of pulmonary hypertension (PHT) in patients with systemic sclerosis (SSc) and no pulmonary symptoms: is annual echocardiographic screening necessary? The incidence of echocardiography-diagnosed PHT with SSc, and no pulmonary symptoms was low. Annual echocardiography is less beneficial among such patients; repeated echocardiography should instead be performed on those with a declining functional class. PubMed, J Clin Rheumatol, 2014 Aug;20(5):268-74. (Also see Echocardiograms for Pulmonary Hypertension)

Novel Ideas: The Increased Skin Viscoelasticity - A Possible New Fifth Sign for the Very Early Diagnosis of Systemic Sclerosis. In combination with nailfold videocapillaroscopy, the increased skin viscoelasticity parameter could be proposed as the possible new fifth sign for the very early diagnosis of SSc. Current Rheumatology Reviews, 08/06/2014. (Also see Diagnosis of Skin Fibrosis and Skin Viscoelasticity)

Old medications and new targeted therapies in systemic sclerosis (SSc). This review focuses on old and new therapies in the management of SSc in clinical practice. PubMed, Rheumatology (Oxford), 2014 Jul 26. (Also see Medications)

Digital ulcers (DUs) as a sentinel sign for early internal organ involvement in very early systemic sclerosis (VEDOSS). Digital ulcers significantly correlate with gastrointestinal involvement and they may be a sentinel sign for early organ involvement. PubMed, Rheumatology (Oxford), 2014 Jul 26. (Also see Digital Ulcers)

Detection of pulmonary vasculopathy by novel analysis of oxygen uptake in patients with systemic sclerosis: association with pulmonary arterial pressures. Some scleroderma patients have decreased oxygen uptake, likely caused by sudden pulmonary arterial pressure increases during exercise. PubMed, Clin Exp Rheumatol, 2014 Jul 17. (Also see Pulmonary Hypertension Diagnosis)

Possible implications of TGF-alpha in eosophageal dysmotility in systemic sclerosis (SSc). These results point to a possible relation between TGF-a and oesophageal dysmotility in SSc, which is intriguing and requires further investigation. PubMed, Clin Exp Rheumatol, 2014 Aug 1. (Also see Dysmotility in Systemic Scleroderma)

Collagenous colitis in systemic sclerosis: an overlooked and treatable complication. Collagenous colitis should be suspected as a rare gastrointestinal complication of systemic sclerosis and clinicians should be aware of the possibility in SSc patients developing watery diarrhea. PubMed, J Clin Rheumatol, 2014 Aug;20(5):278-82. (Also see Inflammatory Bowel Disease)

Left atrial (LA) dysfunction detected by speckle tracking in patients with systemic sclerosis (SSc). 2D speckle-tracking echocardiography is a sensitive tool to assess impairment of LA mechanics, and may represent an early sign of cardiac involvement in patients with systemic sclerosis. PubMed, Cardiovasc Ultrasound, 2014 Aug 5;12(1):30. (Also see Diastolic Dysfunction)

Pulmonary Hypertension (PH) Surveillance. Continued surveillance helps us understand and address the evolving trends in hospitalization and mortality associated with PH and PH-associated conditions, especially regarding sex, age, and race/ethnicity disparities. Chest, 2014;146(2):476-495. (Also see Pulmonary Hypertension Prognosis)

Go to Scleroderma Medical News: August 2014
 
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