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October 2014 Scleroderma News

Long-term survival of patients with pulmonary arterial hypertension (PAH). Patients with PAH who achieve recovery to WHO-FC I or II without use of intravenous epoprostenol have similar survival to those who reach the same WHO-FC with use of intravenous epoprostenol. BMC Research Notes, June 2014; 7: 359. (Also see Pulmonary Hypertension Prognosis)

Validation of a Novel Radiographic Scoring System for Calcinosis Affecting the Hands of Patients with Systemic Sclerosis (SSc). We developed a novel radiographic scoring system that is feasible with excellent reliability, which accounts for the area coverage, density, and anatomic location of calcinosis affecting the hands in patients with SSc. PubMed, Arthritis Care Res, 2014 Aug 22. (Also see Calcinosis)

Major Depression Diagnoses are Often Transient among Patients with Systemic Sclerosis (SSc): Baseline and 1-Month Follow-up. This study suggests that most patients with SSc who meet criteria for major depressive disorder appear to experience mild, time-limited episodes of low mood that often resolve on their own without specific treatment. PubMed, Arthritis Care Res, 2014 Aug 22. (Also see Depression and Scleroderma)

Joint and tendon involvement predict disease progression in systemic sclerosis (SSc): a EUSTAR prospective study. Joint synovitis and tendon friction rubs are independent predictive factors for disease progression in patients with early SSc and these easily detected clinical markers may be useful for the risk stratification of patients with SSc. PubMed, Ann Rheum Dis, 2014 Aug 27. (Also see Hand and Joint Involvement and Tendon Friction Rubs)

Safety, tolerability and potential efficacy of injection of autologous adipose-derived stromal vascular fraction (SVF) in the fingers of patients with systemic sclerosis: an open-label phase I trial. This study outlines the safety of the autologous SVF cells injection in the hands of patients with SSc and a significant improvement in hand disability and pain, Raynaud's phenomenon, finger oedema and quality of life was observed. PubMed, Ann Rheum Dis, 2014 Aug 11. (Also see Vascular Involvement)

Blood flow in the hands of a predefined homogeneous systemic sclerosis population: the presence of digital ulcers (DUs) and the improvement with bosentan. No relationship was found between blood flow in the hands and the presence of DUs. After 12 weeks of bosentan treatment, blood flow had increased in the SSc patients but had not normalized to that of healthy subjects. PubMed, Rheumatology, 2014 Aug 22. (Also see Tracleer/Bosentan For Digital Ulcers)

Mortality, Recurrence, and Hospital Course of Patients with Systemic Sclerosis (SSc)-related Acute Intestinal Pseudo-obstruction. Acute intestinal pseudo-obstruction is a rare gastrointestinal manifestation of SSc with few data existing as to its demographics, clinical course, outcomes, and mortality. PubMed, J Rheumatol, 2014 Aug 15. (Also see Intestinal Pseudo Obstruction)

Lipoic acid (LA) plays a role in scleroderma: insights obtained from scleroderma (SSc) dermal fibroblasts. Dihydrolipoic acid (DHLA) not only acts as an antioxidant but also an antifibrotic since it has the ability to reverse the profibrotic phenotype of SSc dermal fibroblasts. Also thiol antioxidants, including N-acetylcysteine and LA/DHLA, could be beneficial for patients with SSc. PubMed, Arthritis Res Ther, 2014 Aug 15;16(5):411. (Also see Lipoic Acid and Skin Fibrosis Research)

Influence of Pulmonary Vascular Reserve on Exercise-Induced Pulmonary Hypertension (PH) in Patients with Systemic Sclerosis (SSc). The present study demonstrated that exercise-induced PH was common in patients with SSc. Exercise-induced PH might be closely associated with the factors affecting reduced pulmonary vascular reserve in patients with SSc. PubMed, Echocardiography, 2014 Aug 8. (Also see Exercise Induced Pulmonary Hypertension)

No association of atherosclerosis with digital ulcers (DU) in Japanese patients with systemic sclerosis (SSc): evaluation of carotid intima-media thickness (IMT) and plaque characteristics. There were no differences in serum lipid level, carotid IMT or plaque score between SSc patients with and without DU, suggesting that atherosclerotic changes are not primarily involved in the development of DU. PubMed, J Dermatology, 2014 Jul;41(7):604-8. (Also see Athersclerosis and Digital Ulcers)

Go to Scleroderma Medical News: September 2014
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