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December 2014 Scleroderma News

Prognosis in Scleroderma: Sex and the Joints. Joint synovitis and tendon friction rubs are factors which predict disease progression in patients with early systemic sclerosis. The disease is more severe in men and there is a higher risk of severe cardiovascular involvement in men. MedPage Today, 10/29/2014. (Also see Prognosis and Mortality)

Cardiomyopathy in murine models of systemic sclerosis (SSc). Fra-2 tg mice might be a suitable preclinical model to study the mechanisms and therapeutic approaches of myocardial involvement in SSc. ResearchGate Arthritis & Rheumatology, 10/2014. (Also see Cardiac (Heart) Involvement)

Screening for interstitial lung disease in systemic sclerosis: performance of high-resolution CT (HRCT) with limited number of slices: a prospective study. This HRCT protocol reliably detects even mild SSc-ILD in clinical practice, with a much lower radiation dose compared with standard whole-chest HRCT. PubMed, Ann Rheum Dis, 2014 Dec;73(12):2069-73. (Also see High Resolution Computed Tomography)

Acute and regressive scleroderma concomitant to an acute cytomegalovirus (CMV) primary infection. Our observation suggests a potential triggering role of CMV primary infection in the development of scleroderma. Journal of Clinical Virology, 10/20/2014. (Also see Causes of Scleroderma: Infection)

Clinical differences between Thai systemic sclerosis (SSc) patients with positive versus negative anti-topoisomerase l (ATA). A high prevalence of ATA positivity was found among Thai SSc patients and this was associated with a high frequency of hand deformity, anti-centromere negativity, a short duration of pulmonary fibrosis in Diffuse SSc and a lower frequency of Raynaud's phenomenon in Limited SSc. PubMed, Int J Rheum Dis, 10/08/2014. (Also see Antibodies in Systemic Scleroderma)

An Immunochip based interrogation of scleroderma susceptibility variants identifies a novel association at DNASE1L3. This pilot study has confirmed previously reported scleroderma associations, revealed further genetic overlap between scleroderma and systemic lupus erythematosus, and identified a putative novel scleroderma susceptibility locus. PubMed, Arthritis Res Ther, 2014 Oct 21;16(5):438. (Also see Scleroderma in Overlap)

Systemic sclerosis sine scleroderma (ssSSc): a multicenter study of 1417 subjects. This is most likely a forme fruste of limited scleroderma. The absence of skin involvement may in part be related to misclassification arising from early or subtle skin involvement. There is little evidence to consider ssSSc as a distinct clinical or serological subset of SSc. PubMed, J Rheumatol, 2014 Nov;41(11):2179-85. (Also see Systemic Sclerosis Sine Scleroderma)

Prognostic value of N-terminal natriuretic peptides (NT-proANP) in systemic sclerosis (SSc): a single centre study. The high negative predictive value of natriuretic peptides supports the more extensive use in identifying SSc patients with high risk of future cardiac involvement. PubMed, Clin Exp Rheumatol, 2014 Nov-Dec;32 Suppl 6(6):75-81. (Also see Autoimmunity and Heart Disease)

Elevated pentraxin 3 in systemic sclerosis (SSc): Associations with vascular manifestations and defective vasculogenesis. In SSc patients, exposure to high PTX3 concentrations may promote vascular manifestations such as digital ulcers and pulmonary arterial hypertension. PubMed, Arthritis Rheumatol, 11/10/2014. (Also see Vascular Involvement)

Long-term outcome of patients with systemic sclerosis requiring home parenteral nutrition. Home parenteral nutrition can be used safely and effectively in patients with very severe systemic sclerosis-related gastrointestinal involvement. Clinical Nutrition, 11/08/2014. (Also see Enteral or Parenteral Nutrition)

Go to Scleroderma Medical News: November 2014
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