Corbus Pharmaceuticals Initiates Phase 2 Study Patient Enrollment of Resunab for Systemic Sclerosis. Corbus Pharmaceuticals recently announced the initiation of patient enrollment for its Phase 2 trial of Resunab™ for the treatment of diffuse cutaneous systemic sclerosis. Scleroderma News, 09/02/2015. (Also see Clinical Trials)
A Longitudinal Biomarker for the Extent of Skin Disease in Patients with Diffuse Cutaneous Systemic Sclerosis (SSc). Skin gene expression can be used effectively to monitor SSc skin disease change over time. PubMed, Arthritis Rheumatol, 08/03/2015. (Also see Diffuse Scleroderma and Skin Fibrosis)
Study Demonstrates Benefits of Medical Nutrition Therapy (MNT) Intervention in Systemic Sclerosis (SSc) Patients with Gastrointestinal Involvement (GI). Future studies should include direct measures of body composition and should seek to determine the durability of MNT on symptom improvement in a larger number of patients with SSc involving the GI tract. Scleroderma News, 07/27/2015. (Also see Gastrointestinal Involvement and Diet and Scleroderma)
Three-Year Study Reveales Functional Disability and Fatigue Scores Remain Stable in Systemic Sclerosis Patients. Although systemic sclerosis causes increasing disability and symptom aggravation over time, this study contributes to the growing idea that systemic sclerosis is not necessarily a progressive disease. Scleroderma News, 07/30/2015. (Also see Fatigue)
Temporomandibular Joint Disorder (TMJD) Found to Be a Common Condition in Systemic Sclerosis Patients. TMJD is a common condition in systemic sclerosis patients, and it correlates with disease severity. Scleroderma News, 07/24/2015. (Also see Temporomandibular Joint Disorder)
Novel Mechanism Contributing To Skin Fibrosis in Systemic Sclerosis Identified. The TGF–beta signaling pathway is strongly involved with systemic sclerosis pathogenesis. Scleroderma News, 07/31/2015. (Also see Skin Fibrosis)
Autoantibodies against Endothelin 1 Type A Receptor Are Strong Predictors of Digital Ulcers (DU) in Systemic Sclerosis (SSc). Anti–ETAR autoantibodies can be used together with the presence of current or past DU to identify patients with SSc who are at risk for the development of subsequent DU. PubMed, 08/01/2015. (Also see Digital Ulcers)
Epigenetics and systemic sclerosis. The environment can trigger epigenetic regulation that in turn establishes a molecular framework linking environmental exposures to genetics, leading to the disease process, possibly in a genetically predisposed host. PubMed, Semin Immunopathol, 07/11/2015. (Also see Causes of Scleroderma:Genetics)
Late nailfold videocapillaroscopy (NVC) patterns associated with hand calcinosis and acro-osteolysis in systemic sclerosis (SSc). Acro–osteolysis and calcinosis are independently associated with the late NVC pattern, and particularly with severe capillary loss. PubMed, Arthritis Care Res (Hoboken), 07/20/2015. (Also see Bone Resorption in SSc Calcinosis and Nailfold videocapillaroscopy)
A review on quality of life in systemic sclerosis (SSc). It is important for SSc patients to have an interdisciplinary approach towards their cognitive representations of the disease and what they value most. PubMed, Autoimmunity Reviews, 07/29/2015. (Also see Quality of Life with Scleroderma)
The risk of pulmonary embolism and deep venous thrombosis (VTE) in systemic sclerosis (SSc): A general population-based study. SSc patients are at a substantially increased risk of VTE and so increased monitoring for this potentially fatal outcome and its modifiable risk factors is warranted. PubMed, Arthritis Care Research, 07/28/2015. (Also see Antiphospholipid Syndrome)
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