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August 2016 Scleroderma News

Cytori’s Managed Access Program. Cytori’s Managed Access Program in select countries across Europe, the Middle East, and Africa is intended to provide patients with hand impairment due to scleroderma early access to ECCS-50 therapy. Cytori Theraputics Inc. (Also see Scleroderma Clinical Trials)

An Open–label, Phase II Study of the Safety and Tolerability of Pirfenidone in Patients with Scleroderma–associated Interstitial Lung Disease (SSc-ILD): the LOTUSS Trial. Pirfenidone showed an acceptable tolerability profile in SSc–ILD, although a longer titration may be associated with better tolerability. PubMed, J Rheumatol, 07/01/2016. (Also see Completed Scleroderma Clinical Trials: Positive Results)

Disease activity indices (DAI) in systemic sclerosis: a systematic literature review. Future studies are needed to fully validate the European Scleroderma Study Group activity index and the Combined Response Index for Systemic Sclerosis. PubMed, Clin Exp Rheumatol, 07/06/2016. (Also see Prognosis and Mortality)

A candidate gene study identifies a haplotype of CD2 as novel susceptibility factor for systemic sclerosis (SSc). Our study establishes CD2 as a new susceptibility factor for SSc, in a European Caucasian population, confirming the sharing of autoimmune risk factors by SSc and rheumatoid arthritis. PubMed, Clin Exp Rheumatol, 07/01/2016. (Also see Causes of Scleroderma: Genetics)

Quantitative chest computed tomography analysis in patients with systemic sclerosis before and after autologous stem cell transplantation. CT quantification of lung volume and parenchymal attenuation in SSc patients presenting with alveolitis and fibrosis that undergo autologous SCT yields parameters that match well with those of pulmonary function and even clinical tests. PubMed, Rheumatology (Oxford), 06/21/2016. (Also see Diagnosis of Scleroderma Pulmonary Involvement)

Exercise echocardiography for the assessment of pulmonary hypertension in systemic sclerosis: a systematic review. Left ventricle diastolic dysfunction was common and was associated with greater elevation of systolic pulmonary arterial pressure on exercise. BioMed Central, Arthritis Research & Therapy, 07/02/2016. (Also see Pulmonary Hypertension Diagnosis)

Increased risk of digital vascular events in scleroderma patients who have both anti–centromere (CENP) and anti–nterferon–inducible protein 16 (IF–16) antibodies. This study provides further evidence that anti–CENP and anti–IFI–16 antibodies are disease biomarkers that may be used for risk stratification of vascular events in scleroderma. PubMed, Arthritis Care Res (Hoboken), 07/07/2016. (Also see Antibodies in Systemic Scleroderma and Prognosis and Mortality)

An Autotaxin–LPA–IL–6 Amplification Loop Drives Scleroderma (SSc) Fibrosis. Results suggest that concurrent inhibition of two pathways, LPA and IL–6, may be an effective therapeutic strategy for SSc fibrosis. PubMed, Arthritis Rheumatol, 07/07/2016. (Also see Skin Fibrosis)

Functional Dyspepsia and Gastroparesis. Precise identification of the cause and pathophysiology of upper gastrointestinal symptoms is essential for optimal management. PubMed, Dig Dis, 2016;34(5):491-9. (Also see Gastrointestinal Involvement)

Erectile Dysfunction (ED) in Systemic Sclerosis (SSc). ED is a major issue in SSc as it is observed in around 80 to 90 % of men with this connective tissue disease and it greatly impacts the quality of life and should be actively addressed as a common complication. PubMed, Curr Rheumatol Rep, 2016 Aug;18(8):49. (Also see Sexuality and Scleroderma)

Interstitial lung disease (ILD) in systemic sclerosis (SSc): progress in screening and early diagnosis. Lung HRCT appeared promising, but radiation is an issue. Promising biomarker data indicate the possibility of new ILD screening algorithms in SSc. PubMed, Curr Opin Rheumatol, 07/06/2016. (Also see Pulmonary Fibrosis Diagnosis)

Go to Scleroderma Medical News: July 2016
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