SCLERO.ORG
Search

Autoimmune Disease Directory

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer

Overview

Autoimmune KaleidoscopeScleroderma is a rare autoimmune disease that often affects the skin. It is also a form of arthritis and a connective tissue disease.

There are over: 80 autoimmune diseases, 100 types of arthritis, 200 connective tissue disorders, and 3,000 skin diseases. Many of these conditions have similar symptoms or blood work, and they often occur together.

Scleroderma is just one of the Great Imitators, which are diseases that eerily mimic others. Some of the great imitators include extrapulmonary tuberculosis, HIV, lupus, lyme disease, multiple sclerosis, and syphillis.

This can make diagnosis of the more complex autoimmune diseases very challenging. We cover the following illnesses because they may be part of the differential diagnosis of scleroderma, or may sometimes occur along with it. (Also see: What is Scleroderma? and Similar Skin Diseases)

Anemia of Chronic Disease
Antiphospholipid Syndrome
Ankylosing Spondylitis
Arthritis
Asthma
Autoimmunity
Behçet's
Cancer
Celiac Disease
Chronic Fatigue Syndrome
Depression
Dermatomyositis
Diabetes
Ear Diseases, Autoimmune
Endometriosis
Eye Diseases, Autoimmune
Fatigue
Fibromyalgia
Glaucoma/Retinal
Idiopathic Thromocytopenic Purpura
Interstitial Cystitis (Bladder)
Leukemia
MCTD
Multiple Sclerosis
Myasthenia Gravis
Neuromuscular Diseases
Pancreatitis, Autoimmune
Pancytopenia
Polyarteritis Nodosa
Polymyositis
Psoriasis, PsA
Rheumatoid Arthritis
Sarcoidosis
Scleroderma
Similar Skin Diseases
Systemic Lupus (SLE)
Systemic Rheumatic Diseases
Thrombotic Purpura (TTP)
Thyroid Diseases
Tuberculosis, Extrapulmonary
Tuberculous Fasciitis
UCTD
Vasculitis
Vulvodynia
Warts
Wegener's Granulomatosis

Endometriosis

Association of history of surgery for endometriosis with severity of deeply infiltrating endometriosis. A history of surgery for endometriosis correlates with the presence and severity of deeply infiltrating endometriosis, so a thorough preoperative assessment is necessary before undertaking subsequent surgeries. PubMed, Obstet Gynecol, 2014 Oct;124(4):709-17. (Also see Endometriosis)

Role of colonoscopy in the diagnostic work-up of bowel endometriosis. Being an invasive procedure, colonoscopy should not be routinely performed in the diagnostic work-up of bowel endometriosis. PubMed, World J Gastroenterol, 2015 Apr 28;21(16):4997-5001.

Endometriosis Patient Stories

Dawn M: Linear/Systemic Scleroderma My family and I were informed by the doctors, that the localized/linear form of scleroderma that I was diagnosed with, would never progress into the potentially fatal, systemic form...

Krisha S: Multiple Autoimmune Condition I have endometriosis, multiple sclerosis (MS), fibromyalgia, and Stiff Person Syndrome...

Kym: Diffuse, CREST Scleroderma, Lupus and Fibromyalgia It all started with Raynaud's in my fingers and toes when I was about nineteen years old, in 1979...

Nina: Fibromyalgia, Raynaud's, Limited Scleroderma/CREST That is when I found ISN! The volume of reliable, informative, trusted information that I found on this site completely overwhelmed me...

Rachelle: Endometriosis and Interstitial Cystitis I am just happy after two and a half years to know that I have a real answer and I can get better...

Star S: Morphea and Systemic Scleroderma I was diagnosed with morphea at age seven. Now at age thirty-three, I have recently developed systemic scleroderma with gastrointestinal manifestations, Sjogren's syndrome, inflammatory arthritis, malabsorption...

Idiopathic Thrombocytopenic Purpura

What Is Idiopathic Thrombocytopenic Purpura? Idiopathic thrombocytopenic purpura (ITP) is a bleeding condition in which the blood doesn't clot as it should. This is due to a low number of blood cell fragments called platelets. National Heart Lung and Blood Institute.

(Case Report) A rare association of localized scleroderma (LS) type morphea, vitiligo, autoimmune hypothyroidism, pneumonitis, autoimmune thrombocytopenic purpura and central nervous system vasculitis. It is likely that localized scleroderma has an autoimmune origin and in this case becomes part of multiple autoimmune syndrome (MAS), which consist of the presence of three or more well-defined autoimmune diseases in a single patient. PubMed, BMC Res Notes, 2012 Dec 20;5:689 (Also see Causes of Morphea, Vitiligo, Hashimoto's Thyroiditis, Vasculitis, and Multiple Autoimmune Syndrome)

Leukemia

It is rare, but scleroderma has been associated with Large Granular Lymphocyte Leukemia. Medscape.

Neuromuscular Diseases

Neuromuscular diseases that may be associated with scleroderma include polymyositis, dermatomyositis, and inclusion body myositis. (Also see Overlap Syndrome). ISN.

Pancytopenia

Pancytopenia is a medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets. Wikipedia.

Polyarteritis Nodosa (PAN)

Postirradiation morphea and subcutaneous polyarteritis nodosa: Case report and literature review. Postirradiation morphea is an uncommon condition but is being increasingly recognized. Radiation may be responsible for inducing some of the pathogenic changes seen in scleroderma and other autoimmune diseases. PubMed, Semin Arthritis Rheum. 2005 Apr;34(5):728-34. (Also see Causes of Morphea and Causes of Scleroderma: Radiation)

Thrombotic Thrombocytopenic Purpura (TTP)

Thrombotic Thrombocytopenic Purpura (TTP) is a blood disorder that causes blood clots to form in small blood vessels around the body, and leads to a low platelet count (thrombocytopenia). Medline Plus.

Tuberculous Fasciitis in Scleroderma

(Case Report) Tuberculous fasciitis in scleroderma. We here report a case of tuberculous fasciitis manifest with painful swelling of the midposterior muscles of the right thigh without pulmonary tuberculosis in a patient with scleroderma. PubMed, Clin Rheumatol.

Vulvodynia

Vulvodynia: Vaginal pain can occur in Scleroderma patients from Sjögren's causing excessive vaginal dryness.

Warts

Warts. People with immune deficiencies are more susceptible to contracting the virus that causes warts. Common warts, genital warts, and plantar warts are all caused by different strains of the human papillomavirus. Warts.org.

Footnotes

(1) Medscape requires (free) sign up and password. You do not need to be a medical professional to use Medscape. However this makes for slower access to the site for first-time users.

Go to Antiphospholipid Syndrome
 
 

SCLERO.ORG is the world leader for trustworthy research, support, education and awareness for scleroderma and related illnesses, such as pulmonary hypertension. We are a service of the nonprofit International Scleroderma Network (ISN), which is a 501(c)(3) U.S.-based public charitable foundation, established in 2002. Meet Our Team, Volunteer, or Donate.

International Scleroderma Network (ISN)
7455 France Ave So #266
Edina, MN 55435-4702 USA

Email [email protected] to request our Welcome email, or to report or update any page content or links.

Toll Free US/Canada Scleroderma Hotline: 800-564-7099

 
The most important thing in the world to know about scleroderma is sclero.org!
Copyright 1998-2015, International Scleroderma Network. AKA Scleroderma from A to Z and SCLERO.ORG. All Rights Reserved.
Copyright 1998-2015, International Scleroderma Network. AKA Scleroderma from A to Z and SCLERO.ORG. All Rights Reserved.