Anemia of Chronic Disease
Anemia refers to a deficiency in the blood. Anemia most commonly refers to insufficient iron resulting in a shortage of hemoglobin, but the term is also used to indicate vitamin deficiency or blood loss. Anemia can range from mild and temporary to severe and life-threatening. When the anemia is caused by a chronic illness, it is called "anemia of chronic disease."
Anemia: Overview. Many types of anemia exist, each with its own cause. The cause may be an iron or vitamin deficiency, blood loss, a chronic illness, or a genetic or acquired defect or disease. It may also be a side effect of a medication. Anemia can be temporary or long-term. It can range from mild to severe. Mayo Clinic.
When the anemia is caused by a chronic illness, it is called "anemia of chronic disease."
Anemia of Chronic Disease. Conditions associated with the anemia of infection and chronic diseases include such diverse diseases as chronic bacterial endocarditis, osteomyelitis, juvenile rheumatoid arthritis, rheumatic fever, Crohn's disease, and ulcerative colitis. Chronic renal failure may produce a similar anemia because it causes reduced levels of erythropoietin, the hormone which stimulates the production of red blood cells in the bone marrow. HealthCentral.
I often become quite severely anemic, but although I started off with the anemia of chronic disease, it became much more serious when my kidneys failed, and I now have the anemia of kidney failure. (Also see Sherrill Knaggs: My Experience with Anemia)
In both anemia of chronic disease and of kidney failure I was treated with iron infusions by IV. I was told that only about 10% of iron tablets are absorbed by most people regardless of whether they have an autoimmune disease or not, so the iron by IV is much better absorbed. I have proved that too, as each time I have had an iron infusion I come right quite quickly.
Generally speaking B12 injections are usually used for a different sort of anemia called pernicious anemia. In the UK, by far the most common cause of vitamin B12 deficiency is a lack of 'intrinsic factor', a substance which is produced in the stomach and enables the body to absorb vitamin B12 from the diet. Sometimes doctors add B12 for other reasons to treatment with iron, but it doesn't pay to self dose with B12. NetDoctor.com.uk.
To know whether you are deficient with this you should have a blood test. I had one a while back, and my levels were fine, though my iron levels were not.
Sometimes folic acid is also needed as this helps with the manufacture of red blood cells, but once again should not be taken without consulting your doctor.
I was once given B12 injections by a doctor, and I didn't need them. It made my heart do very strange things! If you read the webpage above about B12 deficiency you will find more information, including other possible causes of this deficiency. One is the formation of antibodies against the cells producing intrinsic factor. The cells then die and B12 deficiency and anaemia (Also called pernicious anaemia) develop. Maybe an autoimmune disease can form these antibodies. And it is entirely possible for a patient to have both sorts of anemia simultaneously.
Anemia: Signs and Symptoms. The main symptom of most types of anemia is fatigue. Other signs and symptoms of anemia include: Weakness; Pale skin, including decreased pinkness of your lips, gums, lining of your eyelids, nail beds and palms; A rapid heartbeat; Shortness of breath; Chest pain; Dizziness; Irritability; Numbness or coldness in your hands and feet; Headache. Mayo Clinic.
Diagnosis/Symptoms of Anemia. Extensive information, including blood tests for anemia, treatments, nutrition, and specific conditions related to anemia. Medline Plus.
Iron deficiency (ID) in systemic sclerosis (SSc) patients with and without pulmonary hypertension (PH). ID is more prevalent in SSc-PH than in SSc-nonPH patients and is associated with exercise impairment in both SSc-PH and SSc-nonPH. In addition, ID SSc-PH patients have a significantly worse survival compared with non-ID patients. Rheumatology (2014) 53 (2): 285-292. (Also see What is Scleroderma? and Pulmonary Hypertension)
Prevalence, Correlates and Outcomes of Gastric Antral Vascular Ectasia (GAVE) in Systemic Sclerosis. GAVE is rare and associated with a vascular phenotype, including anti-RNA-polymerase III antibodies, and a high risk of renal crisis. Anemia, usually requiring blood transfusions, is a common complication. Journal of Rheumatology, 12/01/2013. (Also see Gastric Antral Vascular Ectasia, and Renal Involvement)
The Prevalence of Iron Deficiency Anemia (IDA) in Primary Antiphospholipid Syndrome (PAPS). PAPS patients have a higher incidence of IDA and Iron deficient erythropoiesis (IDE) compared to healthy controls. This can be attributed to inadequate ingestion of folic acid and vitamin C. Turkish Journal of Rheumatology. (Also see Antiphospholipid Syndrome)
Watermelon Stomach belongs to a group of gastrointestinal (GI) bleeding problems which are referred to as Arteriovenous Malformations (AVMs.) Untreated, AVMs can cause chronic anemia or acute (sudden or severe) GI bleeding. AVMs can also cause vomiting of blood (hematemesis) or dark, tarry stools which contain blood (melena.) ISN.
Anemia Treatment and Drugs. Anemia treatment depends on the cause. Mayo Clinic.
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