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Myopathy and Myositis

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Myopathy vs. Myositis
Myopathies and Scleroderma
Myopathies and Overlapping Diseases

Myopathy vs. Myositis

Myopathy means muscle disease. Myositis means muscle disease that is caused by inflammation. There are three types of myositis: dermatomyositis, polymyositis, and inclusion body myositis. (Also see Autoimmune Diseases, and Dermatomyositis/Polymyositis)

Myopathies. Myopathy is the medical term for muscle disease. There are many causes of muscle disease, such as infection, muscle injury due to medications, inherited diseases affecting muscle function, disorders of electrolyte levels, and thyroid disease. Some of these disorders, such as polymyositis, dermatomyositis and inclusion body myositis, develop when the immune system attacks muscles. The primary symptom of myopathies is muscle weakness. American College of Rheumatology.

Myositis. Myositis is inflammation of your skeletal muscles, which are also called the voluntary muscles. These are the muscles you consciously control that help you move your body. An injury, infection or autoimmune disease can cause myositis. The diseases dermatomyositis and polymyositis both involve myositis. MedlinePlus.

Myopathies and Scleroderma

Lower Limb Strength Impacts Systemic Sclerosis Patient's Quality of Life and Functional Capacity, According to Study Patients with systemic sclerosis have reduced respiratory muscle and quadriceps strength and these muscles are more susceptible to fatigue. Scleroderma News, 03/30/2015. (Also see Musculoskeletal Involvement)

Novel autoantibodies in inflammatory myopathies and systemic sclerosis. The scope of this article is to review the diagnostic and prognostic value of antibodies in inflammatory myopathies and systemic sclerosis. PubMed, Rev Med Suisse, 2015 Jan 14;11(456-457):25-9. (Also see Antibodies in Systemic Scleroderma)

Clinical and laboratory features of overlap syndromes (OS) of idiopathic inflammatory myopathies associated with systemic lupus erythematosus, systemic sclerosis, or rheumatoid arthritis. This is the first study to show the different characteristics of a series of patients with connective tissue disease (CTD)-OS in the heterogeneous Brazilian population. PubMed, Clin Rheumatol, 07/04/2014. (Also see Scleroderma in Overlap)

Dropped head syndrome in a patient with scleromyocitis. Dropped head syndrome (DHS) may be the first manifestation of a systemic autoimmune disease. PubMed, J Clin Rheumatol, 2013 Jan;19(1):32-4.

Myopathies and Overlapping Diseases

Assessment of Mortality in Autoimmune Myositis With and Without Associated Interstitial Lung Disease. Our results suggest that ILD remains an important and significant source of mortality in patients with inflammatory myopathies and as such should be screened for and treated aggressively. PubMed, Lung, 2016 Oct;194(5):733-7.

Anti-MDA5 is associated with rapidly progressive lung disease and poor survival in U.S. patients with amyopathic (CADM) and myopathic dermatomyositis (DM). Anti-MDA5 antibody is significantly associated with interstitial lung disease, rapidly progressing interstitial lung disease, worse pulmonary outcome, and survival in US classic DM and CADM patients. PubMed, Arthritis Care Res (Hoboken), 09/28/2015.

Myositis Mimics. Some of the most common acquired and inherited muscle diseases that can mimic autoimmune myositis are reviewed. PubMed, Curr Rheumatol Rep, 2015 Oct;17(10):541.

Eosinophilic fasciitis associated with myositis. Eosinophilic fasciitis is clinically characterized by symmetrical scleroderma-like indurations of the skin with pain. The histological features are fascial inflammation with lymphocytes and eosinophils as well as thickened and fibrotic fascia. PubMed, Case Rep Dermatol, 2015 Apr 30;7(1):79-83. (Also see Eosinophilic Fasciitis)

Anti-thyroid drugs-related myopathy: is carbimazole the real culprit? After commencing ATDs, early recognition of this rare condition and close monitoring are the essence of management. PubMed, Int J Endocrinol Metab, 2015 Jan 22;13(1):e17570. (Also see Thyroid Diseases)

Clinical and laboratory features of overlap syndromes of idiopathic inflammatory myopathies associated with systemic lupus erythematosus (SLE), systemic sclerosis (SSc), or rheumatoid arthritis (RA). The clinical manifestations of dermatomyositis/polymyositis were identified simultaneously with SSc and RA in the majority of cases, in contrast to identification in the SLE group. PubMed, Clin Rheumatol, 2014 Aug;33(8):1093-8. (Also see Lupus in Overlap and Rheumatoid Arthritis in Overlap)

Myositis-specific and myositis-associated autoantibody profiles and their clinical associations in a large series of patients with polymyositis and dermatomyositis. Anti-Ro-52 was correlated with pulmonary disorders in dermatomyositis, whereas anti-Jo-1 was correlated with pulmonary alterations in polymyositis. PMC, Clinics (Sao Paulo), 2013 Jul; 68(7): 909–914.

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