Antibodies in Lupus

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Antiphospholipid (aPL)
C Reactive Protein (CRP)
Scl-70 (topo-I) (ATA)


There are a wide variety of autoantibodies associated with lupus. Some of the antibodies are helpful in diagnosing the illness, while others are more useful in detecting disease activity or potential complications. (Also see Autoimmune Diseases and Overview of Lupus)

Distinct antibody profile: a clue to primary antiphospholipid syndrome (PAPS) evolving into systemic lupus erythematosus (SLE)? The detection of a distinct subgroup of lupus-associated autoantibody in PAPS patients seems to be a hint to overt SLE disease, particularly in those patients with young age at diagnosis. PubMed, Clin Rheumatol, 2014 Jan 14. (Also see Antiphospholipid Syndrome)

Autoantibodies and SLE-the threshold for disease. The current findings are summarized regarding the presence of SLE-associated antibodies in apparently healthy individuals, and provide opinions on what such discoveries might tell us about the roles of autoantibodies in the development of disease. PubMed, Nat Rev Rheumatol, 2013 Dec 3. (Also see Autoantibodies)

Lots of autoantibodies equal systemic lupus erythematosus (SLE)? Autoantibodies may be found years before an autoimmune disease becomes clinically apparent and in patients with early SLE; no single antibody class or specificity is associated with progression to SLE. Arthritis Research & Therapy 2013, 15:102.

Anti–CII Antibodies

Anti–CII antibody as a novel indicator to assess disease activity in systemic lupus erythematosus (SLE). Anti–dsDNA Abs and complement factors have been used as indicators of lupus activity and therefore, anti–CII Ab could be a novel indicator for monitoring activity of SLE. PubMed, Lupus, 06/05/2015.

Antiphospholipid Antibodies (aPL)

Antiphospholipid antibodies in patients with upper-extremity deep vein thrombosis (UEDVT). UEDVT could be the first clinical symptom of Antiphospholipid syndrome, and may be the first clinical manifestation of preceding the development of Systemic Lupus Erythematosus by several years. PubMed, Cent Eur J Immunol, 2015;40(3):307–310. (Also see Antiphospholipid Syndrome)

The role of antiphospholipid autoantibodies (aPL) in the cognitive deficits of patients with systemic lupus erythematosus (SLE). Results support the relationship between aPL and cognitive symptoms in SLE. PubMed, Lupus, 02/18/2015.

Cigarette smoking, antiphospholipid antibodies (aPL) and vascular events (VE) in Systemic Lupus Erythematosus (SLE). Among ever regular smokers who were aPL positive, there was a strikingly high frequency of former VE and the underlying mechanisms and temporality between smoking, aPL and VE need further investigations. PubMed, Ann Rheum Dis, 2014 Apr 1. (Also see Antiphospholid Syndrome)

C Reactive Protein (Anti-CRP)

Anti-CRP antibodies in systemic lupus erythematosus. Anti-CRP autoantibodies, which are found in 35 to 40% of SLE patients, increase the cardiovascular risk by interacting with the monomeric (degraded) form of CRP. PubMed, Joint Bone Spine.

NKG2A Antibodies

Anti-NKG2A autoantibodies in a patient with systemic lupus erythematosus (SLE). NKG2A autoantibodies are rare, but when they occur they may contribute to the pathogenesis by increasing the killing of cells and the release of autoantigens. PubMed, Rheumatology, 2013 Jul 3.

Scl-70 (topo-I)(ATA)

Anti-Scl-70 (topo-I) antibodies (ATA) in Systemic Lupus Erythematosus (SLE): Myth or reality? Given that SLE is approximately 100 times more prevalent than systemic sclerosis (SSc), the number of ATA positive SLE patients is 2-3 orders of magnitude greater than the prevalence of ATA in SSc. Autoimmun Rev, 2010 Jun 22. (Also see: Overview of Lupus)

SM (Anti-SM antibodies)

Anti–Sm is associated with the early poor outcome of lupus nephritis. Our data suggest that anti–Sm identified at kidney biopsy might have a predictive value for the early poor outcome of biopsy–proven lupus nephritis during the follow–up period. PubMed, Int J Rheum Dis, 04/29/2016. (Also see Symptoms and Complications of Lupus)

Go to Treatments for Lupus
Most Recent Donors

Winn Schillberg
Reading Voices of Scleroderma Books: Diana Kramer.
Sharing Scleroderma Awareness Bracelets: Deb Martin, Brenda Miller, Vickie Risner.
Thanks to UNITED WAY donors of Central New Mexico and Snohomish County!

In Loving Memory

Patricia Ann Black: Marilyn Currier, Shelley Ensz, Richard Howitt, Gerald and Pat Ivanejko, Juno Beach Condo Association, Keith and Rosalyn Miller, and Elaine Wible.
Gayle Hedlin: Daniel and Joann Pepper and Nancy Smithberg.
Janet Paulmenn: Anonymous, Mary Jo Austin, Shelley Blaser, Susan Book, Dennis and Pat Clayton, Grace Cunha, Cindy Dorio, Michael and Patricia Donahue, Shelley Ensz, Nancy Falkenhagen, Jo Frowde, Alice Gigl, Margaret Hollywood, Karen Khalaf and Family, Susan Kvarantan, Bradley Lawrence, Jillyan Little, Donna Madge, Michele Maxson, Barry and Judith McCabe, John Moffett, My Tribute Foundation, Joan-Marie Permison, John Roberts, Margaret Roof, Maryellen Ryan, Mayalin and Kiralee Murphy, Nancy Settle-Murphy, and Bruce and Elizabeth Winter.


SCLERO.ORG is the world leader for trustworthy research, support, education and awareness for scleroderma and related illnesses, such as pulmonary hypertension. We are a service of the nonprofit International Scleroderma Network (ISN), which is a 501(c)(3) U.S.-based public charitable foundation, established in 2002. Meet Our Team, or Volunteer. Donations may also be mailed to:

International Scleroderma Network (ISN)
7455 France Ave So #266
Edina, MN 55435-4702 USA

Email [email protected] to request our Welcome email, or to report bad links or to update this page content.

TOLL FREE HOTLINE 800-564-7099
Free to U.S. and Canadian Callers. Ask for our Free Info Packet by mail or email!
Scleroderma, Pulmonary Arterial Hypertension, and related illnesses.
Privacy Policy.

The most important thing in the world to know about scleroderma is!
Donate Now
Copyright 1998-2016, International Scleroderma Network. AKA Scleroderma from A to Z and SCLERO.ORG. All Rights Reserved.