Diagnosis of Rheumatoid Arthritis

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overview Antibodies


Rheumatoid arthritis is generally diagnosed and treated by rheumatologists, in most countries.

A new window of opportunity in rheumatoid arthritis: targeting at-risk individuals. The prospective study of at–risk individuals can provide invaluable aetiological insights as well as facilitating accurate risk prediction data and in this way, high–risk individuals may be identified for preventive interventions. PubMed, Curr Opin Rheumatol, 2016 May;28(3):260-6.

Differentiation between early rheumatoid and early psoriatic arthritis by the ultrasonographic (US) study of the synovio–entheseal complex of the small joints of the hands. The US involvement of synovio–entheseal complex and US extrasynovial features may be helpful in the differential diagnosis between early rheumatoid and early psoriatic arthritis. PubMed, Clin Exp Rheumatol, 03/03/2016. (Also see Psoriasis and Psoriatic Arthritis)

Rheumatoid Arthritis: Notable Biomarkers Linking to Chronic Systemic Conditions and Cancer. Due to the complex nature of the disease, the appearance of symptoms and markers vary amongst individuals and the connections may manifest only in part. PubMed, Curr Pharm Des, 12/09/2015. (Also see Cancer)

Biomarkers for rheumatoid and psoriatic arthritis. Biomarkers are required to enable earlier diagnosis and predict prognosis in both rheumatoid arthritis and psoriatic arthritis. PubMed, Clin Immunol, 04/28/2015. (Also see Psoriasis and Psoriatic Arthritis)

Antibodies of Rheumatoid Arthritis

Surface APRIL Is Elevated on Myeloid Cells and Is Associated with Disease Activity in Patients with Rheumatoid Arthritis. Surface APRIL is elevated in circulating myeloid cells in patients with RA where it is highly correlated with disease activity. PubMed, J Rheumatol, 03/01/2015.

Seronegative rheumatoid arthritis (RA): Pathogenetic and therapeutic aspects. Focusing on seronegative RA, this review considers these concepts and their implications for the management of patients with this challenging, though sometimes overlooked, condition. PubMed, Best Pract Res Clin Rheumatol, 2014 Aug;28(4):651-659.

Recognition of new citrulline containing peptide epitopes by autoantibodies produced in vivo and in vitro by B cells of Rheumatoid arthritis patients. Anti-citrullinated peptide/protein antibodies (ACPAs) are highly sensitive and specific markers of rheumatoid arthritis (RA). Identification of peptide epitopes that may detect different subgroups of RA patients might have diagnostic and prognostic significance. Immunology, 10/04/2013.

New Autoantibodies in early Rheumatoid Arthritis. These autoantibodies could be used as diagnosis markers in RA patients. PubMed, Arthritis Res Ther, 2013 Jul 25;15(4):R78. (Also see Autoantibodies)

Enzyme-Activating Antibodies Revealed As Marker For Most Severe Form Of Rheumatoid Arthritis. This study represents the first evidence of an antibody having a direct role in generating the targets of the immune response. Johns Hopkins Medicine, 05/22/2013.

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