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Sarcoidosis

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overview
Causes
Diagnosis
Symptoms
Treatment
Personal Stories

Overview: What is Sarcoidosis?

Sarcoidosis KaleidoscopeSarcoidosis typically begins in the lungs, however it can affect any part of the body. The first symptom of sarcoidosis is usually shortness of breath.

What is Sarcoidosis? Sarcoidosis is an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands. In patients with sarcoidosis, abnormal masses or nodules (called granulomas) consisting of inflamed tissues form in certain organs of the body. These granulomas might alter the normal structure and possibly the function of the affected organ(s). Cleveland Clinic.

Sarcoidosis. Sarcoidosis is an inflammatory disease that starts in your lungs, but in time it can affect virtually any organ in your body, including your liver, skin, heart, nervous system and eyes. Mayo Clinic.

Causes

Genetics of sarcoidosis. Biology approaches will soon help unravel the differing and common features of sarcoidosis with other granulomatous disorders and also with diseases with significantly different phenotypes and allow the development of new therapeutic strategies and tools. PubMed, Semin Respir Crit Care Med, 2014 Jun;35(3):296-306.

ß-Glucan in BAL Among Patients With Sarcoidosis. The results further support the hypothesis that exposure to fungi is important for the risk of sarcoidosis. Chest Journal. October 2012, Vol 142, No. 4.

Diagnosis

Sarcoidosis Diagnosis. There is no single way to diagnose sarcoidosis, since all the symptoms and laboratory results can occur in other diseases. UCSF.

Concomitant sarcoidosis and a connective tissue disease (CTD). A significant portion of patients with CTDs and sarcoidosis may actually not have the latter disease and the diagnosis of a concomitant connective tissue disease and sarcoidosis must be made with extreme caution. PubMed, Respir Med, 2013 Sep;107(9):1453-9. (Also see Connective Tissue Disease)

Symptoms

Possible Signs and Symptoms. Shortness of breath (dyspnea) and a cough that won't go away can be among the first symptoms of sarcoidosis. But sarcoidosis can also show up suddenly with the appearance of skin rashes. MedicinceNet.com

How are cancer and connective tissue diseases (CTDs) related to sarcoidosis? The association between sarcoidosis and both cancer and CTDs may yield important insights into the immunopathogenesis of all three diseases. PubMed, Curr Opin Pulm Med, 2015 Sep;21(5):517-24. (Also see Connective Tissue Disease and Cancer)

Excessive Daytime Sleepiness (EDS) and Obstructive Sleep Apnea (OSA) in Patients With Sarcoidosis. Sleepiness may contribute to the morbidity of sarcoidosis which is independently associated with EDS and should be followed even after treating for potentially coexisting OSA or depression. Chest Journal, June 2013, Vol 143, No. 6. (Also see Sleep Apnea)

Treatment

How is Sarcoidosis Treated? The goals of treatment are to improve how the organs affected by sarcoidosis work, relieve symptoms, shrink the granulomas. National Heart Lung and Blood Institute.

Clinicopathological features of sarcoidosis manifesting as generalized chronic myopathy. Muscle biopsy specimens revealed an active inflammatory process and functional improvement after immunomodulatory treatment was significantly better in patients with short disease durations. PubMed, J Neurol, 2015 Apr;262(4):1035-45.

Sarcoidosis-associated pulmonary hypertension (SAPH) and lung transplantation for sarcoidosis. Lung transplantation is a viable therapeutic option for sarcoid patients with severe pulmonary fibrocystic sarcoidosis or SAPH refractory to medical therapy. PubMed, Semin Respir Crit Care Med, 2014 Jun;35(3):362-71.

Personal Stories

Debs B: Diffuse Systemic Sclerosis (England) This seems to be a long list of ailments that I have been coping with for years, so the addition of diffuse systemic sclerosis did not really panic me…

Missie R: Mixed Connective Tissue Disease I finally asked for an ANA test to check for lupus. My family doctor hesitated because my symptoms were all over the board…

Yolima: Diffuse Scleroderma I was misdiagnosed for more than a year with so many diseases and given all types of medication for different problems except for the real disease…

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