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Cytokines

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overview
Cytokines and Interleukins
Cytokines and Scleroderma
Cytokines and Sleep

Overview

Cytokines are small secreted proteins which mediate and regulate immunity, inflammation, and hematopoiesis. Cytokines can cause inflammation associated with a variety of autoimmune diseases. (Also see Causes of Scleroderma, What is Scleroderma?, Types of Scleroderma, and Systemic Sclerosis)

Association Between Corrected QT (QTc) Interval and Inflammatory Cytokines in Rheumatoid Arthritis (RA). A lower inflammatory burden may protect against QTc prolongation in patients with RA. PubMed, J Rheumatol, 01/15/2015.

Scleroderma-related lung disease: are adipokines involved pathogenically? The systemic nature of scleroderma-related lung disease has led many to implicate circulating factors in the pathogenesis of some of its organ impairment. PubMed, Curr Rheumatol Rep, 2013 Dec;15(12):381. (Also see Pulmonary Fibrosis)

Cytokines and Interleukins

Overview
Anti-TNF-a Therapies
Interleukin-1{alpha}
Interleukin-6
Interleukin-8
Interleukin-10
Interleukin-12
Interleukin-13
Interleukin-17
Interleukin-20
Interleukin-22
Interleukin-23
Interleukin-25
Interleukin-27
Interleukin-33

Cytokines and Scleroderma

(Case Report) Coexistence of Ankylosing Spondylitis (AS) With Morphea. Morphea and AS with an inflammatory background and active immunity can exist in the same patient and recent studies have showed the importance of Th17 and associated cytokines in the pathogenesis of these two diseases. Archives of Rheumatology 2014, Volume 29, Number 2, P 143-146. (Also see Morphea and Ankylosing Spondylitis)

Interleukin-17 and interleukin-23: importance in the pathogenesis of lung impairment in patients with systemic sclerosis (SSc). The changes in concentrations of IL-17, IL-21 and IL-23 support the hypothesis that these cytokines may play a role in the pathogenesis of SSc. PubMed, Int J Rheum Dis, 2014 Jan 28.

Cytokines and Sleep

Sleep Impairment: A Trigger for Relapse in IBD? Certain cytokines are known to interfere with sleep, and sleep deprivation results in upregulation of cytokines. Medscape, 01/23/2014. (Also see Sleep Disorders and Illness)

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