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Causes of Scleroderma: Artificial Joints and Silicone Breast Implants

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Device Implantation Research Personal Stories Related to Implants

Device Implantation Research

Are some cases of connective tissue disease, such as scleroderma, related to artificial joints or silicone breast implants? Contradictory findings continue to plague research into this area.

Silicone and scleroderma revisited. This review describes the mechanisms by which silicone may mediate autoimmunity in general, as well as the evidence for causal associations with more specific autoimmune syndromes in general, and scleroderma in particular. Lupus.

Also see: Causes of Scleroderma: Silica Exposure.

Systemic sclerosis (SSc) with anti-RNA polymerase III positivity following silicone breast implant rupture: possible role of B–cell depletion and implant removal in the treatment. This result may support data suggesting that B-cell depleting therapy may decrease specific autoantibody level in SSc patients, and that these changes are associated with disease improvement. PubMed, Rheumatol Int, 02/03/2017. (Also see B Cells and T Cells)

Personal Stories Related to Implants

Cindy Fuchs-Morrissey: Mother of a Progressive Systemic Sclerosis Child Hilary has an aggressive form of scleroderma with swallowing problems, bowel problems, fatigue, acral bone dysplasia of the hands and feet…

Jewell: Diffuse Progressive Systemic Sclerosis When I think back, I had been getting sick for a long time. I just did not know it…

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