Causes of Scleroderma: Vaccinations

Overview of Vaccinations and Scleroderma
Vaccinations and Autoimmune Disease
Heptatitis B Vaccination and Diffuse Scleroderma
Vaccinations and Morphea Scleroderma

Overview of Vaccinations and Scleroderma

Vaccinations have been suspected as a cause of scleroderma, in a few cases. Hepatitis B vaccine was ruled to cause a case of diffuse scleroderma in a U.S. court. Morphea profunda has been identified at the site of an injection. Trauma is one of the known causes of morphea. Since vaccines are a form of trauma, they may be the cause of morphea, in some cases; that is, the trauma is the issue, not the contents of the vaccine itself.

Vaccinations and Autoimmune Diseases

EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases. Recommendations for vaccination in patients with AIIRD based on the currently available evidence and expert opinion were formulated. More research is needed, particularly regarding the incidence of vaccine-preventable infectious diseases and the safety of vaccination in patients with AIIRD. Ann Rheum Dis doi:10.1136/ard.2010.137216.

Autoimmune response following influenza vaccination in patients with autoimmune inflammatory rheumatic disease (AIRD). Although seasonal and H1N1 vaccines are safe and effective, they also have the potential to induce autoantibodies in selected AIRD patients and healthy adults. PubMed, Lupus, 2012;21(2):175-83.

Consequence or coincidence? The occurrence, pathogenesis and significance of autoimmune manifestations after viral vaccines.PubMed, Vaccine. 2005 Jun 10;23(30):3876-86.

Autoimmune diseases and vaccinations. We suggest that a potential link between vaccines and autoimmune diseases cannot be definitely ruled out and should be carefully explored during the development of new candidate vaccines. PubMed, Eur J Dermatol. 2004 Mar-Apr;14(2):86-90.

Hepatitis B Vaccination and Diffuse Scleroderma

(PDF) Hepatitis B Vaccine Caused Diffused Scleroderma, Special Master Finds. A Vaccine Court special master ruled that a nurse provided sufficient evidence that hepatitis B vaccine caused diffuse scleroderma and encouraged the parties to settle. US Courts, [2007].. (Also see Types of Scleroderma and Diffuse Scleroderma)

Vaccinations and Morphea Scleroderma

Primary Atrophic Solitary Morphea Profunda. Here, we describe a patient presenting with noninflammatory cupuliform (shaped like a small cup) depressed plaques, without any significant skin induration, pigmentation or texture change, that appeared on the left shoulder at a site of previous intramuscular vaccination. Our observation highlights the wide spectrum of clinical presentations of localized scleroderma. The latter should be considered in the presence of lipoatrophy-like lesions for proper workup and therapy. (Also see Lipodystrophy and Morphea Profunda)

Deep Morphea after Vaccination in Two Young Children. Trauma has been implicated as an important trigger of morphea, both in children and in adults. Furthermore, vaccines might induce an immune response, which could lead to morphea in predisposed individuals. Pediatric Dermatology Volume 23 Issue 5, Pages 484 - 487, 27 Sep 2006. (Also see Morphea Scleroderma and Causes of Morphea Scleroderma)

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