Causes of Scleroderma: Oxidative Stress, Lipid Peroxidation

Oxidative stress is an imbalance between pro-oxidants and antioxidants that can result in cellular degeneration. Oxidative stress is characterized by the release of free radicals, highly reactive molecules that can steal electrons from lipids resulting in cellular damage, a process referred to as lipid peroxidation.

Oxidative stress parameters in localized scleroderma patients. Oxidative stress seems to be effective in the pathogenesis of localized scleroderma and arylesterase levels have increased in morphea patients. PubMed, Arch Dermatol Res, 09/03/2016.

Oxidative stress in Mexicans with diffuse cutaneous systemic sclerosis (dcSSc). Mexican dcSSc patients had elevated lipid/protein oxidative stress (OS) with respect to healthy controls. Erythrocyte sedimentation rate (ESR) and C-reactive Protein (CRP) were elevated in a great number of dcSSc patients which suggests that they have a continuous stimulus for endothelial dysfunction and accelerated atherogenesis. PubMed, Rheumatol Int, 2013 Mar 2. (Also see What is Scleroderma?)

Oxidative stress and antioxidants in interstitial lung disease (ILD). The limited number of ILD patients necessitates multicenter trials to obtain enough power to reach clinically relevant data. The specific fibrotic toxicity of O2 might be a lead in the development of new therapies and of suggesting optimal antioxidant dietary regimes. A. Bast. (PubMed) Curr Opin Pulm Med, 2010 Sep.

Exercise in systemic sclerosis (SSc) intensifies systemic inflammation and oxidative stress. Although exercise capacity is impaired in patients with SSc, physical activity intensifies the already increased basal levels of systemic inflammation and oxidative stress. These data support the concept of a role for systemic inflammation and oxidative stress in the ongoing systemic effects of SSc. H Harðardóttir. (PubMed) Scand J Rheumatol, 2010;39(1):63-70.

Vascular Inflammation in Obesity and Sleep Apnea. Untreated obstructive sleep apnea rather than obesity is a major determinant of vascular endothelial dysfunction, inflammation, and elevated oxidative stress in obese patients. Sanja Jelic MD. Circulation. February 16, 2010 (Also see Sleep Apnea)

Go to Cause of Scleroderma: Stress
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