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Causes of Scleroderma: Oxidative Stress, Lipid Peroxidation

Oxidative stress is an imbalance between pro-oxidants and antioxidants that can result in cellular degeneration. Oxidative stress is characterized by the release of free radicals, highly reactive molecules that can steal electrons from lipids resulting in cellular damage, a process referred to as lipid peroxidation.

Bone marrow–derived mesenchymal stem cells (BMSCs) expressing thioredoxin 1 attenuate bleomycin–induced skin fibrosis and oxidative stress in scleroderma (SSc). These results demonstrate that the transplantation of Trx–1–overexpressing BMSCs restored normal skin tissue in a mouse model of bleomycin–induced SSc, highlighting the therapeutic potential of engineered BMSCs for treating SSc. PubMed, J Invest Dermatol, 01/26/2017. (Also see Causes of Scleroderma: Drugs and Medications)

Oxidative stress parameters in localized scleroderma patients. Oxidative stress seems to be effective in the pathogenesis of localized scleroderma and arylesterase levels have increased in morphea patients. PubMed, Arch Dermatol Res, 09/03/2016.

Propylthiouracil (PTU) modulates aortic vasculopathy in the oxidative stress model of systemic sclerosis. PTU, by reducing lipid peroxidation, prevents aortic thickening and myofibroblast differentiation induced by hypochlorous acid, reducing macrovascular alterations in experimental SSc. PubMed, Vascul Pharmacol, 2015 Aug;71:79-83.

Role of cellular senescence and NOX4-mediated oxidative stress in systemic sclerosis pathogenesis. Recent studies examining the role of cellular senescence and of oxidative stress in SSc pathogenesis will be reviewed. PubMed, Curr Rheumatol Rep, 2015 Jan;17(1):473.

Exercise in systemic sclerosis (SSc) intensifies systemic inflammation and oxidative stress. Although exercise capacity is impaired in patients with SSc, physical activity intensifies the already increased basal levels of systemic inflammation and oxidative stress. These data support the concept of a role for systemic inflammation and oxidative stress in the ongoing systemic effects of SSc. PubMed, Scand J Rheumatol.

Go to Cause of Scleroderma: Stress
 
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