Causes of Scleroderma: Oxidative Stress, Lipid Peroxidation

Oxidative stress is an imbalance between pro-oxidants and antioxidants that can result in cellular degeneration. Oxidative stress is characterized by the release of free radicals, highly reactive molecules that can steal electrons from lipids resulting in cellular damage, a process referred to as lipid peroxidation.

Oxidative stress parameters in localized scleroderma patients. Oxidative stress seems to be effective in the pathogenesis of localized scleroderma and arylesterase levels have increased in morphea patients. PubMed, Arch Dermatol Res, 09/03/2016.

Exercise in systemic sclerosis (SSc) intensifies systemic inflammation and oxidative stress. Although exercise capacity is impaired in patients with SSc, physical activity intensifies the already increased basal levels of systemic inflammation and oxidative stress. These data support the concept of a role for systemic inflammation and oxidative stress in the ongoing systemic effects of SSc. (PubMed) Scand J Rheumatol.

Go to Cause of Scleroderma: Stress
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