Oxidative stress is an imbalance between pro-oxidants and antioxidants that can result in cellular degeneration. Oxidative stress is characterized by the release of free radicals, highly reactive molecules that can steal electrons from lipids resulting in cellular damage, a process referred to as lipid peroxidation.
Exercise in systemic sclerosis (SSc) intensifies systemic inflammation and oxidative stress. Although exercise capacity is impaired in patients with SSc, physical activity intensifies the already increased basal levels of systemic inflammation and oxidative stress. These data support the concept of a role for systemic inflammation and oxidative stress in the ongoing systemic effects of SSc. H Harðardóttir. (PubMed) Scand J Rheumatol.
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