Research about Scleroderma Cardiac (Heart) Involvement

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Autoimmunity and Heart Disease
Causes of Heart Disease


Hypothyroidism Contributes to Increased Triglyceride Levels Among Patients with Systemic Sclerosis (SSc). In a cohort of 49 patients with diffuse SSc clinical and laboratory features of hypothyroidism were observed in 27% of the patients and increased triglyceride levels in more than 55%. It is estimated that about half of SSc patients experience overt or latent hypothyroidism. J. Rheumatol, [2006] April;33:827. (Also see Thyroid Disease and Lipoprotein[a] and Thrombotic Complications)

Autoimmunity and Heart Disease

Idiopathic pulmonary fibrosis (IPF) and coronary artery disease. A more extensive cardiopulmonary exercise test should be performed for better management of IPF patients, not only with the goal of identifying useful prognostic parameters, but also to detect potentially treatable cardiovascular alterations earlier. Multidisciplinary Respiratory Medicine 2014, 9:31. (Also see Pulmonary Fibrosis Correlations)

Causes of Heart Disease in Systemic Autoimmune Diseases

Prognostic value of N-terminal natriuretic peptides (NT-proANP) in systemic sclerosis (SSc): a single centre study. The high negative predictive value of natriuretic peptides supports the more extensive use in identifying SSc patients with high risk of future cardiac involvement. PubMed, Clin Exp Rheumatol, 2014 Nov-Dec;32 Suppl 6(6):75-81.

Autonomic dysfunction in patients with systemic sclerosis: Correlation with intrarenal arterial stiffness. Autonomic dysfunction (AD) is a feature of SSc, starting early in the disease and possibly preceding the development of fibrosis. International Journal Of Cardiology, 09/04/2014.

Pericardial involvement in systemic autoimmune diseases. On rare occasions, pericardial effusion and/or pericarditis may be the first clues of a systemic inflammatory disease or a manifestation of a known systemic disease. In these cases, pericardial involvement generally reflects the activity of the systemic disease. Wolters Kluwer Health, 12/14/2012.

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