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Research about Scleroderma Cardiac (Heart) Involvement

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Antibodies
Autoimmunity and Heart Disease
Causes of Heart Disease

Antibodies

Predicting cardiopulmonary involvement in patients with systemic sclerosis: complementary value of nailfold videocapillaroscopy (NVC) patterns and disease–specific autoantibodies. All SSc–specific auto–antibodies were found, with ACA and anti-Scl-70 being the most prevalent and the association between NVC–pattern and heart/lung involvement was independent of specific anti-ENA antibodies, which might indicate microangiopathy is an important cause of organ involvement. PubMed, Rheumatology (Oxford), 12/10/2016. (Also see Antibodies and Nailfold Videocapillaroscopy)

Autoimmunity and Heart Disease

Idiopathic pulmonary fibrosis (IPF) and coronary artery disease. A more extensive cardiopulmonary exercise test should be performed for better management of IPF patients, not only with the goal of identifying useful prognostic parameters, but also to detect potentially treatable cardiovascular alterations earlier. Multidisciplinary Respiratory Medicine 2014, 9:31. (Also see Pulmonary Fibrosis Correlations)

Causes of Heart Disease in Systemic Autoimmune Diseases

Prognostic value of N-terminal natriuretic peptides (NT-proANP) in systemic sclerosis (SSc): a single centre study. The high negative predictive value of natriuretic peptides supports the more extensive use in identifying SSc patients with high risk of future cardiac involvement. PubMed, Clin Exp Rheumatol, 2014 Nov-Dec;32 Suppl 6(6):75-81.

Autonomic dysfunction in patients with systemic sclerosis: Correlation with intrarenal arterial stiffness. Autonomic dysfunction (AD) is a feature of SSc, starting early in the disease and possibly preceding the development of fibrosis. International Journal Of Cardiology, 09/04/2014.

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