Eye Involvement

ISN Guide to Eye Involvement: Dr. Liz Irvin

Dr. Liz IrvinHello, I am Dr. Liz Irvin, your ISN Guide to Eye Involvement. In addition to helping Dr. C. Stephen Foster develop resources for this section of the ISN website, I am happy to try to respond to questions that you may have or to redirect you to resources that may be helpful. Email [email protected].

Normal Tension Glaucoma
Autoimmune Iritis/Uveitis
Optic Neuropathy
Other Eye Diseases of Scleroderma
Eyes in Rheumatic Diseases
Personal Stories
Media Stories

Overview of Eye Involvement in Scleroderma (Systemic Sclerosis)

Eye symptoms and diseases that may be related to scleroderma include normal tension glaucoma, autoimmune iritis or uveitis, and types of optic neuropathy.

Ocular Inflammatory Disease

A Patient Guide to Ocular Inflammatory Disease. This is an online guide, covering symptoms, diagnosis and treatment for inflammatory eye diseases. In addition, printed copies of this guide can be requested free of charge from the Ocular Immunology and Uveitis Foundation. (Also see Dr. C. Stephen Foster, ISN Medical Advisory Board)

Normal Tension Glaucoma (NTG)

Normal Tension Glaucoma. Normal Tension Glaucoma (NTG) is when the optic nerve is damaged even though the pressure inside of the eye is normal. ISN.

NTG and Scleroderma
Symptoms and Diagnosis

Autoimmune Iritis or Uveitis (Eye Inflammation)

Autoimmune Iritis or Uveitis. When inflammation affects the eyes, it is called different things depending on which part of the eye it affects (the iris or the uvea). ISN.


Optic Neuropathy

Optic Neuropathy is a general term used for damage to the optic nerve regardless of the cause of the damage. ISN.

Overview Optic Neuropathy and Scleroderma

Other Eye Diseases of Scleroderma

Case Report Highlights Acute Central Retinal Vein Occlusion (CRVO) in Scleroderma Patient The research team thoroughly analyzed other causes of CRVO besides scleroderma, concluding that scleroderma was the most likely cause for this patient’s condition. Scleroderma News, 03/30/2015.

Localized Scleroderma (Morphea, Linear, En Coup de Sabre)

Prospective study to evaluate the clinical and radiological outcome of patients with scleroderma of the face. Patients with localized scleroderma of the face have a high prevalence of neurological and ophthalmological changes. All cases of localized scleroderma of the face should be thoroughly examined for the presence of systemic changes. PubMed. (Also see Types of Scleroderma, Localized Scleroderma, Neurological Involvement)

Pellucid Marginal Degeneration and Systemic Sclerosis (Scleroderma)

(Case Report) Pellucid marginal degeneration and scleroderma. Pellucid marginal degeneration is characterized by non-inflammatory and progressive peripheral corneal thinning inferiorly, often with high against-the-rule astigmatism. PubMed, Clin Exp Optom. 2004 May;87(3):180-4.

Pyoderma Gangrenosum and Systemic Sclerosis (Scleroderma)

Sclerokeratitis and facial skin lesions: a case report of pyoderma gangrenosum and its response to dapsone therapy. Pyoderma gangrenosum is a rare autoimmune disorder that can affect the eye. Biopsy of affected tissue is the key to diagnosis. Immunomodulating therapy can be a useful adjunct to the traditional steroid therapy. PubMed, Cornea, 2007 Feb;26(2):215-9.

Retinopathy and Systemic Sclerosis (Scleroderma)

Intact Calibers of Retinal Vessels in Patients with Systemic Sclerosis (SSc). The evidence that retinal microcirculation is spared in SSc suggests that fibroproliferative vasculopathy may depend on specific cellular or soluble factors not present in the retinal environment. PubMed, J Rheumatol, 02/01/2015.

(Case Reports) Acute retinal artery occlusion in systemic sclerosis: A rare manifestation of systemic sclerosis fibroproliferative vasculopathy. We describe the clinical features, laboratory and ancillary examinations of the three patients with SSc who developed acute unilateral blindness. Seminars in Arthritis and Rheumatism.

Eye Involvement of Rheumatic Diseases

LASIK in Autoimmune Disease
Dry Eyes

Support for Eye Diseases

Ask Dr. Foster
Support Groups
Related Pages
Go to Autoimmune Uveitis and Iritis (Eye Inflammation)
Recent Donors
See ISN News for recent donors, including memorials for
Christine Kane, Lilian and Lee Stiles, Charles Kendrick Watts and Marta Marx.

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