Biomarkers for Scleroderma GI
Correlation with Other Symptoms
Dysphagia (Difficulty Swallowing)
Esophagus (Throat) Involvement
|Esophagus: Reflux (Heartburn)
GAVE (Watermelon Stomach)
Loss of Appetite
GI involvement consists of a variety of symptoms and conditions that include nausea and vomiting, difficulty with swallowing, constipation, diarrhea, GERD (gastroesophageal reflux disease), problems with digestion, gastroparesis, and watermelon stomach.
Some of these symptoms are bothersome and can have a serious affect on your quality of life. Others are life threatening. All should be taken seriously and discussed with your doctor. (Also see Scleroderma Gastrointestinal Involvement, What is Scleroderma?, Types of Scleroderma, and Systemic Sclerosis
Evaluation and management of gastrointestinal manifestations in scleroderma (SSc). Patient care is being optimized by close collaboration of rheumatologists and gastroenterologists, leading to a more coordinated approach in the management of gastrointestinal manifestations of SSc. PubMed, Curr Opin Rheumatol, 2014 Nov;26(6):621-9.
Evidence for oesophageal and anorectal involvement in very early systemic sclerosis (VEDOSS). In patients with VEDOSS, oesophageal and anorectal disorders are frequently detected, showing that very early SSc is characterised by GI involvement. PubMed, Ann Rheum Dis, 2013 Oct 15.
Systemic sclerosis and the gut. GI complications are common, second only to skin involvement, and affect up to 90% of systemic sclerosis (SSc) patients. PubMed, Expert Rev Gastroenterol Hepatol, 2013 May;7(4):331-9.
Profile of gastrointestinal involvement in patients with systemic sclerosis. The results of the study show that in reality, a much higher (nearly all) percentage of (98,9%) patients than expected suffer from GI-symptoms, regardless of the stage of their disease. T. Schmeiser, (SpringerLink) Rheumatology International. July 2011.
Fecal calprotectin: A biomarker of gastrointestinal disease in systemic sclerosis. Fecal calprotectin is increased in a majority of patients with systemic sclerosis (SSc). It correlates with objective and clinically important features of GI disease, and fecal concentrations do not vary with plasma concentrations. Intern Med 2011; 270: 50-57 (Also see Systemic Sclerosis Prognosis and Mortality: Biomarkers)
Sleep disturbances in systemic sclerosis (SSc): evidence for the role of gastrointestinal symptoms, pain and pruritus. Gastrointestinal symptoms, pain and pruritus were associated with sleep disturbance in SSc. Additional research is needed on sleep in SSc so that well-informed sleep interventions can be developed and tested. PubMed, Rheumatology, 2013 Jun 25. (Also see Sleep Disorders and Scleroderma, Pain, and Scleroderma Skin Involvement: Itching)
Systemic scleroderma can affect the entire digestive tract, affecting swallowing, digestion, and elimination.
Bowel Involvement. Scleroderma can cause constipation, diarrhea, malabsorption, diminished peristalsis, intestinal pseudo-obstruction, and bowel incontinence. Typical in the initial stages of scleroderma is chronic constipation, sometimes alternating with diarrhea. Late stage scleroderma bowel involvement is often marked by diarrhea, malabsorption, and bowel incontinence. ISN.
Causes of Bowel Dysfunction
|Intestinal Bacterial Overgrowth
Inflammatory Bowel Disease (IBD)
Irritable Bowel Syndrome (IBS)
Dysmotility syndrome refers to muscles in the gastrointestinal tract not working properly. This can include the throat (esophagus), stomach, and bowels. When the stomach is affected, it is often called gastroparesis. When it affects the bowels, it may be called intestinal pseudo-obstruction. ISN. (Also see Esophagus, Gastroparesis, and Bowel Involvement)
Correlation with other Complications
Dysphagia is the medical term for difficulty in swallowing. Symptoms include a sensation of food sticking in the throat, chest pressure or 'burning' after eating, or a feeling of choking. Dysphagia can be due to many different things. Occasionally it is one of the symptoms of systemic scleroderma. ISN.
Liquefied Food for Dysphagia
|Enteral or Parenteral Nutrition (TPN)
Dysphagia Personal Stories
Esophageal (Throat) Involvement. Scleroderma can cause Barrett's Esophagus, esophageal diseases, esophageal stricture, and esophageal ulcers. ISN.
Correlation with Lung Disease
Dysphonia (Hoarseness, Loss of Voice)
|Esophageal Motility Disorders
Gastric MALT Lymphoma
Esophagus: Reflux (Heartburn) and GERD. There are many effective treatments and lifestyle modifications for reflux (heartburn) which is very common in scleroderma patients. ISN.
Cough Due to Heartburn
Heartburn, GERD and Scleroderma
About Reflux (Heartburn)
Reflux and Atrial Fibrillation
Reflux and Lung Involvement
Reflux Prevention and Treatments
What is Gastroparesis? Symptoms, diagnosis, treatments, and support. Gastroparesis and Dysmotilities Association.
Jason: Linear Scleroderma I have recently been diagnosed with Raynaud's as well, have had gastrointestinal difficulties more common to systemic forms, and have witnessed these lesions grow and deepen rather than decrease in size...
Jody: Fibromyalgia/Difficult Diagnosis In Sudan, I was on IV for heat stroke and food poisoning. And in Thailand, at the end of March, it all came to a crashing halt...
Sandy J: CREST Scleroderma I have had an ileostomy for two years and a feeding peg for just over one year, and would appreciate comments from any person who also has one or both of these problems...
Tami: Morphea Scleroderma I have gotten used to the stares everyone casts my way because in their eyes I am different. Unique, I guess...
Trish: Spouse of a Diffuse Scleroderma Patient My husband was diagnosed with scleroderma in June of 2000...
A loss of appetite can occur for a great many reasons, including anxiety, depression, infection, medication and treatment side-effects, and many illnesses. There are medications that can stimulate appetite, as well as treat nausea. Loss of appetite in a scleroderma patient may be indicative of gastrointestinal involvement. If appetite loss persists, it is important to consult your medical care provider.
Serum albumin is not useful as a marker for malnutrition in scleroderma.
Nutritional status as marker for disease activity and severity predicting mortality in patients with systemic sclerosis (SSc). In patients with SSc, malnutrition is common and not identified by Body Mass Index (BMI). Bioelectrical impedance analysis (BIA) parameters reflect disease severity and provide best predictors for patient survival. Therefore, an assessment of nutritional status should be performed in patients with SSc. Lijana Krause. Ann Rheum Dis. May 2010. (Also see Diet and Scleroderma)
Case Report: Benign Spontaneous Pneumoperitoneum in Systemic Sclerosis (SSc). We report a case of spontaneous pneumoperitoneum (air or gas in the abdominal (peritoneal) cavity) without evidence of peritoneal irritation in a malnourished patient with long-standing SSc. PubMed, J Clin Rheumatol, 2010 Dec;16(8):379-81.
Watermelon Stomach is the popular name for Gastric Antral Vascular Ectasia (GAVE) — a condition in which the lining of the stomach bleeds, causing it to look like the characteristic stripes of a watermelon when viewed by endoscopy. ISN.
|What is Watermelon Stomach?
|A Patient's Perspective
Watermelon Stomach in Associated with Other Diseases
Measuring response in the gastrointestinal tract (GIT) in systemic sclerosis. Recommendations are given for trial design and evaluation of GIT involvement in SSc. PubMed, Curr Opin Rheumatol, 2013 Nov;25(6):700-6.
Validation of the UCLA Scleroderma Clinical Trial Gastrointestinal Tract Instrument (SCTC GITI) Version 2.0 for Systemic Sclerosis. Our study confirms that the UCLA SCTC GITI version 2.0 will be a useful tool for assessing the role of GI involvement in SSc, even in a population with substantially different characteristics than the subjects originally tested. Baron M. (PubMed) J Rheumatol, 2011 Jul 1.
Nausea and Vomiting Many illnesses can cause stomach pain, nausea and vomiting. Some are mild sicknesses that will pass by themselves, but others are serious and need medical attention. familydoctor.org.
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